Trials / Completed
CompletedNCT00016458
Phase II Pilot Study of Cyclophosphamide and Rabbit Anti-Thymocyte Globulin as Salvage Therapy in Patients With Diffuse Systemic Sclerosis
- Status
- Completed
- Phase
- Phase 2
- Study type
- Interventional
- Enrollment
- 20 (planned)
- Sponsor
- Fred Hutchinson Cancer Center · Academic / Other
- Sex
- All
- Age
- 64 Years
- Healthy volunteers
- Not accepted
Summary
OBJECTIVES: I. Determine the toxicity of cyclophosphamide and rabbit anti-thymocyte globulin in patients with diffuse systemic sclerosis. II. Determine the efficacy of this regimen in terms of controlling disease in these patients.
Detailed description
PROTOCOL OUTLINE: Patients receive cyclophosphamide IV over 1-2 hours on day 1 and rabbit anti-thymocyte globulin IV over 6-8 hours on days 2-5. Patients are followed on days 60-85 and then every 3 months for 1 year.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | anti-thymocyte globulin | |
| DRUG | cyclophosphamide |
Timeline
- Start date
- 2000-06-01
- First posted
- 2001-05-07
- Last updated
- 2008-09-03
Locations
3 sites across 1 country: United States
Source: ClinicalTrials.gov record NCT00016458. Inclusion in this directory is not an endorsement.