NCT01836263

Prevention and Treatment of Digital Ulcers in Systemic Sclerosis

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 420 (estimated)
• Sponsor: marco matucci cerinic · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

Systemic sclerosis is an orphan, multiorgan disease affecting the connective tissue of the skin and several internal organs. Digital ulcers are frequent and have a major impact on the quality of life in patients with systemic sclerosis. The etiology of digital ulcers is complex and multifactorial and the principal mechanisms underlying the digital ulcers formation are ischemic, mechanic and inflammatory, alone or in combination, on the basis of the systemic sclerosis vasculopathy. Consequently, there are at least three types of DU: (i) those localized at the tips of the fingers and toes, mainly resulting from an ischemic process, (ii) those localized on the dorsal aspect of the fingers where the skin retraction due to fibrosis over bony prominences seems to be the main cause, and (iii) those evolving on a pitting scar or subcutaneous calcinosis due to a combined irritative-inflammatory mechanism. An early therapy to prevent or rapidly heal digital ulcers is today considered a mandatory approach to maintain quality of life and spare the enormous costs due to conventional digital ulcer management. This observational trial is part of the collaborative project "DeSScipher", one out of five observational trials to decipher the optimal management of systemic sclerosis. Aim of this observational trial is: 1. To identify the best treatment combination for prevention of digital ulcers in patients with fulfilment of the new ACR/EULAR SSc criteria or the preliminary VEDOSS criteria for very early diagnosis of systemic sclerosis 2. To identify the best treatment associated with improved healing of digital ulcers in patients with fulfilment of the new ACR/EULAR SSc criteria Thus, the observational trial consist of a prevention arm and a healing arm.

Conditions

• Systemic Sclerosis
• Ulcer

Timeline

• Start date: 2013-04-01
• Primary completion: 2017-06-01
• Completion: 2017-06-01
• First posted: 2013-04-19
• Last updated: 2013-04-25

Locations

11 sites across 6 countries: France, Germany, Hungary, Italy, Switzerland, United Kingdom