| Withdrawn | A Study of Macitentan in Children Below 2 Years of Age Arterial Hypertension, Pulmonary | Phase 1 | 2024-03-14 |
| Completed | A Study of Two Macitentan Formulations in Healthy Adult Participants Healthy | Phase 1 | 2022-06-22 |
| Completed | A Study of Single and Multiple Doses of Different Formulations of a Prostacyclin Receptor Agonist Pulmonary Arterial Hypertension | Phase 1 | 2022-06-21 |
| Completed | A Study of Two Different Test Formulations Compared to the Reference Formulation of Macitentan in Healthy Adul Healthy | Phase 1 | 2022-05-25 |
| Recruiting | A Study Providing Treatment Access in Participants With Pulmonary Hypertension Completing a Parent Study and H Hypertension, Pulmonary | Phase 3 | 2022-05-04 |
| Completed | A Study of Fixed Dose Combination of Macitentan/Tadalafil (10 mg/20 mg) Compared to the Reference Free Combina Healthy | Phase 1 | 2022-02-04 |
| Terminated | A Study of Real-world Cohort of Pulmonary Arterial Hypertension (PAH) Participants Pulmonary Arterial Hypertension | Phase 4 | 2021-10-14 |
| Completed | A Study of Two Macitentan Pediatric Formulations in Healthy Adult Participants Healthy | Phase 1 | 2021-07-08 |
| Terminated | A Study of Selexipag Assessing Right Ventricular Remodeling in Pulmonary Arterial Hypertension by Cardiac Magn Pulmonary Arterial Hypertension | Phase 4 | 2021-07-07 |
| Completed | A Study of Selexipag in Participants Who Participated in a Previous Selexipag Study Hypertension, Pulmonary | Phase 3 | 2021-05-03 |
| Terminated | A Study in Participants With Sarcoidosis-associated Pulmonary Hypertension (SAPH) to Assess the Efficacy and S Sarcoidosis-associated Pulmonary Hypertension | Phase 2 | 2021-02-26 |
| Completed | A Study for the Identification of Biomarker Signatures for Diagnosis of Pulmonary Hypertension (PH) in Partici Hypertension, Pulmonary | EARLY_Phase 1 | 2020-12-11 |
| Terminated | A Study to Evaluate Efficacy and Safety of Macitentan 75 mg in Inoperable or Persistent/Recurrent Chronic Thro Chronic Thromboembolic Pulmonary Hypertension | Phase 3 | 2020-07-07 |
| Active Not Recruiting | Outcome Study Assessing a 75 Milligrams (mg) Dose of Macitentan in Patients With Pulmonary Arterial Hypertensi Pulmonary Arterial Hypertension | Phase 3 | 2020-06-30 |
| Completed | Safety and Efficacy of Miglustat in Chinese NPC Patients Niemann-Pick Disease, Type C | Phase 4 | 2020-04-02 |
| Completed | A Study of Selexipag in Healthy Male Participant Healthy | Phase 1 | 2020-01-23 |
| Active Not Recruiting | A Study of Selexipag as Add-On Treatment to Standard of Care in Children With Pulmonary Arterial Hypertension Hypertension, Pulmonary | Phase 3 | 2020-01-16 |
| Completed | A 2-part Study to Investigate the Effect of Macitentan in Healthy Male Participants Healthy | Phase 1 | 2020-01-14 |
| Completed | Clinical Study to Compare the Efficacy and Safety of Macitentan and Tadalafil Monotherapies With the Correspon Pulmonary Arterial Hypertension (PAH) (WHO Group 1 PH) | Phase 3 | 2019-07-29 |
| Terminated | An Upcoming Clinical Study to Measure the Safety and Impact of a Drug Called Macitentan in Teenage and Adult F Congenital Heart Disease With Fontan Circulation | Phase 3 | 2019-04-11 |
| Terminated | A Study to Find Out if Selexipag is Effective and Safe in Patients With Chronic Thromboembolic Pulmonary Hyper Chronic Thromboembolic Pulmonary Hypertension | Phase 3 | 2019-01-23 |
| Terminated | A Clinical Study to Find Out if Macitentan is Effective and Safe in Japanese Patients With Chronic Thromboembo Chronic Thromboembolic Pulmonary Hypertension (CTEPH) | Phase 3 | 2019-01-08 |
| Terminated | A Long Term Study to Find Out if Macitentan is an Effective and Safe Treatment for Patients With Heart Failure Heart Failure With Preserved Ejection Fraction and Pulmonary Vascular Disease | Phase 2 | 2018-12-07 |
| Active Not Recruiting | A Clinical Study of to Confirm the Doses of Selexipag in Children With Pulmonary Arterial Hypertension Pulmonary Arterial Hypertension | Phase 2 | 2018-07-23 |
| Completed | A Clinical Study to Investigate the Long-term Safety of the Drug Macitentan in Patients With Pulmonary Hyperte Pulmonary Arterial Hypertension, Chronic Thromboembolic Pulmonary Hypertension | Phase 3 | 2018-04-05 |
| Completed | A Clinical Study to Assess the Effect of Clopidogrel on the Pharmacokinetics of Selexipag and Its Active Metab Healthy Subjects | Phase 1 | 2018-03-05 |
| Completed | Clinical Study to Investigate Effect of Macitentan on Riociguat Pharmacokinetics Healthy Subjects | Phase 1 | 2018-01-09 |
| Completed | Safety Study of the Switch From Oral Selexipag to Intravenous Selexipag in Subjects With Stable Pulmonary Arte Pulmonary Arterial Hypertension | Phase 3 | 2017-12-04 |
| Completed | Effect of Selexipag on Daily Life Physical Activity of Patients With Pulmonary Arterial Hypertension. Pulmonary Arterial Hypertension | Phase 4 | 2017-11-08 |
| Completed | Clinical Study to Investigate the Effect of Macitentan on the Concentrations of Rosuvastatin in the Blood of H Healthy Subjects | Phase 1 | 2017-11-03 |
| Completed | A Study to Assess Whether Macitentan Delays Disease Progression in Children With Pulmonary Arterial Hypertensi Pulmonary Arterial Hypertension | Phase 3 | 2017-10-24 |
| Completed | Clinical Study Assessing the Efficacy and Safety of Macitentan in Fontan-palliated Subjects Congenital Heart Disease | Phase 3 | 2017-08-14 |
| Completed | A Study to Compare the Macitentan-tadalafil Fixed Dose Combination Tablet Relative to the Concomitant Administ Healthy Subjects | Phase 1 | 2017-08-07 |
| Completed | Retrospective Chart Review of First-time Opsumit® (Macitentan) Users in the United States Pulmonary Arterial Hypertension | — | 2017-08-03 |
| Completed | A Study to Evaluate Whether Macitentan is an Effective and Safe Treatment for Patients With Heart Failure With Heart Failure With Preserved Ejection Fraction | Phase 2 | 2017-07-11 |
| Completed | Long-term Extension to Study AC-058B301 to Investigate Safety, Tolerability and Disease Control of Ponesimod 2 Multiple Sclerosis | Phase 3 | 2017-07-05 |
| Terminated | Comparison of Cadazolid Versus Vancomycin in Children With Clostridium Difficile-associated Diarrhea (CDAD) Clostridium Difficile Infection | Phase 2 / Phase 3 | 2017-04-14 |
| Terminated | Clinical Study to Compare the Efficacy and Safety of Ponesimod to Placebo in Subjects With Active Relapsing Mu Multiple Sclerosis | Phase 3 | 2017-03-30 |
| Completed | A Registry for Patients Taking Uptravi Pulmonary Arterial Hypertension | — | 2016-11-01 |
| Terminated | Clinical Study to Investigate the Biological Activity, Safety, Tolerability, and Pharmacokinetics of Ponesimod Chronic Graft Versus Host Disease | Phase 2 | 2016-09-29 |
| Completed | Potential Pharmacokinetic Interaction Between Selexipag and Midazolam in Healthy Male Subjects Healthy Subjects | Phase 1 | 2016-07-01 |
| Completed | A Clinical Study to Investigate the Effect of Gemfibrozil or Rifampicin on Blood Concentrations of Selexipag i Healthy Subjects | Phase 1 | 2016-06-01 |
| Completed | Comparison of Two Dose Strengths of Selexipag in Healthy Adults Healthy Subjects | Phase 1 | 2016-06-01 |
| Completed | The Efficacy and Safety of Initial Triple Versus Initial Dual Oral Combination Therapy in Patients With Newly Pulmonary Arterial Hypertension | Phase 3 | 2016-05-01 |
| Completed | Clinical Study to Assess the Efficacy and Safety of Macitentan in Patients With Pulmonary Hypertension After L Pulmonary Hypertension | Phase 2 | 2016-03-28 |
| Completed | Study to Assess the Tolerability and the Safety of the Transition From Inhaled Treprostinil to Oral Selexipag Pulmonary Arterial Hypertension | Phase 3 | 2015-10-12 |
| Terminated | Clinical Study Evaluating the Effects of First-line Oral cOmbination theraPy of maciTentan and tadalafIl in Pa Pulmonary Arterial Hypertension | Phase 4 | 2015-09-01 |
| Completed | Comparison of the Pharmacokinetic Properties of Two Tablet Formulations of Macitentan in Healthy Adults Healthy Subjects | Phase 1 | 2015-08-01 |
| Completed | PORtopulmonary Hypertension Treatment wIth maCitentan - a randOmized Clinical Trial Portopulmonary Hypertension | Phase 4 | 2015-06-23 |
| Completed | Oral Ponesimod Versus Teriflunomide In Relapsing MUltiple Sclerosis Multiple Sclerosis | Phase 3 | 2015-06-04 |
| Completed | REPAIR: Right vEntricular Remodeling in Pulmonary ArterIal hypeRtension Pulmonary Arterial Hypertension | Phase 4 | 2015-06-01 |
| Completed | Clinical Study to Assess the Safety, Tolerability and Efficacy of Macitentan in Subjects With Inoperable Chron Chronic Thromboembolic Pulmonary Hypertension | Phase 2 | 2015-02-03 |
| Withdrawn | Correlation of LONGterm Wrist ACTigraphy Recorded Physical Performance & 6-minute Walk Distance in Patients Wi Pulmonary Arterial Hypertension | — | 2015-01-31 |
| Terminated | Clinical Study on Macitentan, RT and TMZ Concurrent Therapy Followed by Maintenance Macitentan and TMZ in Newl Glioblastoma | Phase 1 | 2015-01-08 |
| Completed | Absolute Bioavailability of a Single Oral Dose of Selexipag in Healthy Subjects Healthy Subjects | Phase 1 | 2015-01-01 |
| Completed | Effects of Selexipag in Adults With Raynaud's Phenomenon Secondary to Systemic Sclerosis Raynaud's Phenomenon Secondary to Systemic Sclerosis | Phase 2 | 2014-10-01 |
| Completed | Clinical Study to Assess the Efficacy, Safety and Tolerability of Macitentan in Subjects With Inoperable Chron Chronic Thromboembolic Pulmonary Hypertension | Phase 2 | 2014-08-20 |
| Completed | Study to Investigate the Absolute Bioavailability of a Single Oral Dose of Ponesimod in Healthy Male Subjects Healthy | Phase 1 | 2014-08-01 |
| Completed | Clinical Study to Evaluate the Safety and Tolerability of Macitentan in Subjects With Combined Pre- and Post-c Pulmonary Hypertension | Phase 2 | 2014-07-01 |
| Completed | Extension of the Psychometric Validation Study ORCHESTRA in Patients With PAH Pulmonary Arterial Hypertension | Phase 3 | 2014-06-23 |
| Completed | OPsumit USers Registry Pulmonary Arterial Hypertension | — | 2014-04-30 |
| Completed | Efficacy and Safety of Cadazolid Versus Vancomycin in Subjects With Clostridium Difficile - Associated Diarrhe Clostridium Difficile Infection | Phase 3 | 2014-03-27 |
| Terminated | A Pulmonary Arterial Hypertension Study With Macitentan to Validate the PAH-SYMPACT™ in France, Italy and Spai Pulmonary Arterial Hypertension | Phase 3 | 2014-03-01 |
| Completed | Efficacy and Safety of Cadazolid Versus Vancomycin in Subjects With Clostridium Difficile-associated Diarrhea Clostridium Difficile Infection | Phase 3 | 2013-12-12 |
| Terminated | Clinical Study to Assess the Long-term Safety, Tolerability, and Efficacy of Macitentan in Subjects With Eisen Pulmonary Arterial Hypertension | Phase 3 | 2013-09-10 |
| Terminated | Clinical Study of Macitentan in Patients With PAH to Psychometrically Validate PAH-SYMPACT Instrument Pulmonary Arterial Hypertension | Phase 3 | 2013-09-01 |
| Completed | Clinical Study to Evaluate the Effects of Macitentan on Exercise Capacity in Subjects With Eisenmenger Syndrom Pulmonary Arterial Hypertension | Phase 3 | 2013-05-21 |
| Completed | Clinical Study of Macitentan in Patients With Pulmonary Arterial Hypertension to Psychometrically Validate the Pulmonary Arterial Hypertension | Phase 3 | 2013-04-01 |
| Completed | Two Period / Two Treatment Cross-over to Assess the Effect of Florastor® on Gastrointestinal Tolerability, Saf Diarrhea | Phase 1 | 2013-03-01 |
| Completed | Study in Healthy Male Subjects to Demonstrate Bioequivalence of 1600 μg Selexipag Administered as Eight Tablet Bioequivalence | Phase 1 | 2012-09-01 |
| Completed | Study to Investigate the Pharmacokinetics and Safety of Cadazolid in Patients With Clostridium Difficile Infec Clostridium Difficile Infection | Phase 1 | 2012-08-01 |
| Completed | Eisenmenger Quality Enhancement Research Initiative Pulmonary Arterial Hypertension | — | 2012-07-01 |
| Completed | Study of Selexipag and Its Metabolite ACT-333679 on Cardiac Repolarization in Healthy Male and Female Subjects Cardiodynamics, Safety, Tolerability | Phase 1 | 2012-06-01 |
| Terminated | Effects of Ventavis in Patients With Pulmonary Hypertension (PH) Secondary to Chronic Obstructive Pulmonary Di Chronic Obstructive Pulmonary Disease, Pulmonary Hypertension | Phase 2 | 2012-03-01 |
| Terminated | Clinical Study on the Safety and Tolerability of Macitentan in Combination With Dose-dense Temozolomide in Pat Glioblastoma | Phase 1 | 2012-01-01 |
| Completed | Adult Congenital Heart Disease Registry (QuERI) Pulmonary Arterial Hypertension | — | 2011-12-01 |
| Terminated | Persistent Pulmonary Hypertension of the Newborn Persistent Pulmonary Hypertension of the Newborn | Phase 3 | 2011-12-01 |
| Completed | Macitentan for the Treatment of Digital Ulcers in Systemic Sclerosis Patients Systemic Sclerosis, Ulcers | Phase 3 | 2011-12-01 |
| Terminated | Macitentan for the Treatment of Digital Ulcers in Systemic Sclerosis Patients Digital Ulcers | Phase 3 | 2011-12-01 |
| Completed | Study to Assess the Effect of Macitentan on the Electrocardiogram (ECG) in Healthy Male and Female Subjects Healthy | Phase 1 | 2011-08-01 |
| Completed | Study of the Electrocardiographic Effects of Ponesimod in Healthy Male and Female Subjects Healthy | Phase 1 | 2011-08-01 |
| Withdrawn | Safety and Tolerability Study of Macitentan in Patients With Idiopathic Pulmonary Fibrosis Idiopathic Pulmonary Fibrosis | Phase 2 | 2011-07-31 |
| Completed | Pulmonary Arterial Hypertension Quality Enhancement Research Initiative Extension Program Pulmonary Arterial Hypertension | — | 2011-06-01 |
| Completed | Epoprostenol for Injection in Patients With Pulmonary Arterial Hypertension Pulmonary Arterial Hypertension | Phase 3 | 2011-06-01 |
| Completed | FUTURE 3 Study Extension Pulmonary Arterial Hypertension | Phase 3 | 2011-03-08 |
| Completed | Effects of Two Dosing Regimens of Bosentan in Children With Pulmonary Arterial Hypertension Pulmonary Arterial Hypertension | Phase 3 | 2011-03-08 |
| Completed | Bosentan in Systemic Sclerosis Systemic Sclerosis, Digital Ulcers | Phase 4 | 2011-03-01 |
| Completed | Epoprostenol for Injection (EFI/ACT-385781A) - Pulmonary Arterial Hypertension Pulmonary Arterial Hypertension | Phase 3 | 2011-03-01 |
| Completed | Efficacy, Safety and Tolerability of Cadazolid in Subjects With Clostridium Difficile Associated Diarrhea (CDA Clostridium Difficile Infection | Phase 2 | 2011-01-25 |
| Completed | Digital Ulceration Systemic Sclerosis, Digital Ulcers | — | 2011-01-01 |
| Completed | ACT-128800 in Patients With Moderate to Severe Chronic Plaque Psoriasis Psoriasis | Phase 2 | 2010-10-31 |
| Completed | ACT-293987 in Pulmonary Arterial Hypertension Pulmonary Arterial Hypertension | Phase 3 | 2010-07-07 |
| Completed | Clinical Study to Investigate the Long-term Safety, Tolerability, and Efficacy of Ponesimod in Patients With R Multiple Sclerosis | Phase 2 | 2010-05-12 |
| Completed | Epoprostenol for Injection in Pulmonary Arterial Hypertension - Extension of AC-066A401 Pulmonary Arterial Hypertension | Phase 4 | 2010-05-01 |
| Completed | Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ACT-128800 in Healthy Safety and Tolerability | Phase 1 | 2010-04-01 |
| Completed | Epoprostenol for Injection in Pulmonary Arterial Hypertension Pulmonary Arterial Hypertension | Phase 4 | 2010-03-01 |
| Completed | Selexipag (ACT-293987) in Pulmonary Arterial Hypertension Pulmonary Arterial Hypertension | Phase 3 | 2009-12-01 |
| Completed | Clinical Study to Evaluate the Efficacy, Safety, and Tolerability of ACT-128800 in Patients With Relapsing-rem Multiple Sclerosis | Phase 2 | 2009-10-01 |
| Completed | Macitentan Use in an Idiopathic Pulmonary Fibrosis Clinical Study Idiopathic Pulmonary Fibrosis | Phase 2 | 2009-05-01 |
| Terminated | Ventavis® Registry Protocol Pulmonary Arterial Hypertension | — | 2009-03-01 |
| Completed | Mass Balance, Pharmacokinetics, and Metabolism of 14C-labeled ACT-128800 Administered to Healthy Male Subjects Pharmacokinetics | Phase 1 | 2009-03-01 |
| Completed | Study to Evaluate the Pharmacokinetics, Tolerability, and Safety of ACT-128800 in Japanese and Caucasian Healt Healthy | Phase 1 | 2009-02-01 |
| Completed | Clinical Study to Assess the Long-term Safety and Tolerability of ACT 064992 in Patients With Symptomatic Pulm Pulmonary Arterial Hypertension | Phase 3 | 2008-10-17 |
| Completed | ACT-128800 in Psoriasis Plaque Psoriasis | Phase 2 | 2008-10-01 |
| Terminated | Early, Simple and Reliable Detection of Pulmonary Arterial Hypertension (PAH) in Systemic Sclerosis (SSc) Systemic Sclerosis, Pulmonary Arterial Hypertension, Pulmonary Hypertension | — | 2008-10-01 |
| Completed | Safety Study Extension of Iloprost Power 15 in Pulmonary Arterial Hypertension Pulmonary Arterial Hypertension | Phase 3 | 2008-09-01 |
| Completed | Miglustat in Cystic Fibrosis Cystic Fibrosis | Phase 2 | 2008-08-01 |
| Completed | Iloprost Power 15 in Pulmonary Arterial Hypertension Pulmonary Arterial Hypertension | Phase 3 | 2008-07-01 |
| Terminated | Iloprost Power Disc-15 in Pulmonary Arterial Hypertension Pulmonary Arterial Hypertension | Phase 3 | 2008-07-01 |
| Completed | Study of Macitentan (ACT-064992) on Morbidity and Mortality in Patients With Symptomatic Pulmonary Arterial Hy Pulmonary Arterial Hypertension | Phase 3 | 2008-05-01 |
| Completed | Study of ACT-293987 (NS-304) in Pulmonary Arterial Hypertension (PAH) Pulmonary Arterial Hypertension | Phase 2 | 2008-04-30 |
| Completed | Open Label Extension Study in Patients With Idiopathic Pulmonary Fibrosis Who Completed Protocol AC-052-321/ B Idiopathic Pulmonary Fibrosis | Phase 3 | 2008-04-01 |
| Terminated | Miglustat / OGT 918 in the Treatment of Cystic Fibrosis Cystic Fibrosis | Phase 2 | 2007-11-01 |
| Completed | Combination Therapy in Pulmonary Arterial Hypertension Pulmonary Arterial Hypertension | Phase 4 | 2007-03-01 |
| Completed | BUILD 3: Bosentan Use in Interstitial Lung Disease Idiopathic Pulmonary Fibrosis | Phase 3 | 2007-02-01 |
| Terminated | The "Power 15 Study": Safety Study of Inhalation of Ventavis With the Power Disc-15 Setting Pulmonary Hypertension | Phase 2 | 2006-09-01 |
| Withdrawn | Safety and Efficacy of Inhaled Iloprost in Pediatric Patients With Pulmonary Arterial Hypertension Pulmonary Arterial Hypertension | Phase 2 | 2006-07-01 |
| Completed | Effects of the Combination of Bosentan and Sildenafil Versus Sildenafil Monotherapy on Pulmonary Arterial Hype Pulmonary Arterial Hypertension | Phase 4 | 2006-05-01 |
| Completed | Pulmonary Artery Remodelling With Bosentan Hypertension, Pulmonary | Phase 4 | 2006-05-01 |
| Terminated | Efficacy and Safety of Bosentan in Sickle Cell Disease (SCD) Patients Diagnosed With Pulmonary Hypertension (P Pulmonary Hypertension | Phase 3 | 2006-04-01 |
| Terminated | Efficacy and Safety of Bosentan in Sickle Cell Disease (SCD) Patients With Pulmonary Arterial Hypertension (PA Pulmonary Hypertension | Phase 3 | 2006-03-01 |
| Completed | REVEAL Registry™: Registry to Evaluate Early And Long-term PAH Disease Management Pulmonary Hypertension | — | 2006-03-01 |
| Terminated | A Study of Patients Having Pulmonary Hypertension Associated With Sickle Cell Disease and Completing an ASSET Pulmonary Hypertension, Sickle Cell Anemia | Phase 3 | 2006-03-01 |
| Terminated | The "VISION" Trial: Ventavis Inhalation With Sildenafil to Improve and Optimize Pulmonary Arterial Hypertensio Pulmonary Hypertension | Phase 3 | 2006-02-01 |
| Completed | Clinical Study to Evaluate the Long Term Efficacy, Safety and Tolerability of Miglustat in Patients With Stabl Gaucher Disease Type 1 | Phase 3 | 2006-02-01 |
| Completed | Bosentan in Patients With Inoperable Chronic Thromboembolic Pulmonary Hypertension (CTEPH) Pulmonary Hypertension | Phase 3 | 2006-01-01 |
| Completed | Bosentan Effects in Inoperable Forms of Chronic Thromboembolic Pulmonary Hypertension Chronic Thromboembolic Pulmonary Hypertension | Phase 3 | 2005-10-01 |
| Completed | Effect of Bosentan in Patients With Metastatic Melanoma Treated With Dacarbazine (DTIC) Melanoma | Phase 2 | 2005-09-01 |
| Completed | Bosentan in Children With Pulmonary Arterial Hypertension Extension Study Pulmonary Arterial Hypertension | Phase 3 | 2005-08-23 |
| Completed | Bosentan in Children With Pulmonary Arterial Hypertension Pulmonary Arterial Hypertension | Phase 3 | 2005-05-01 |
| Completed | Inhaled Iloprost in Adults With Abnormal Pulmonary Pressure and Associated With Idiopathic Pulmonary Fibrosis Pulmonary Fibrosis, Pulmonary Hypertension | Phase 2 | 2005-04-01 |
| Completed | Bosentan in Digital Ulcers Digital Ulcers | Phase 3 | 2004-07-08 |
| Completed | Open-label Study With Bosentan in Interstitial Lung Disease Interstitial Lung Disease, Scleroderma | Phase 2 / Phase 3 | 2004-07-01 |
| Completed | Trial of Iloprost Inhaled Solution as Add-On Therapy With Bosentan in Subjects With Pulmonary Arterial Hyperte Pulmonary Arterial Hypertension, Ayerza Syndrome, Pulmonary Hypertension | Phase 2 | 2004-06-01 |
| Completed | Efficacy and Safety of Oral Bosentan in Pulmonary Arterial Hypertension Class II Pulmonary Hypertension | Phase 3 | 2004-04-01 |
| Completed | BREATHE 5-OL: Tracleer (Bosentan) in Patients With Pulmonary Arterial Hypertension Related to Eisenmenger Phys Pulmonary Arterial Hypertension | Phase 4 | 2004-01-01 |
| Completed | Efficacy and Safety of Oral Bosentan on Healing/Prevention of Digital (Finger) Ulcers in Patients With Sclerod Digital Ulcers, Systemic Sclerosis | Phase 3 | 2003-10-01 |
| Completed | Effects of Tracleer (Bosentan) on Pulmonary Arterial Hypertension Related to Eisenmenger Physiology Pulmonary Arterial Hypertension Related to Eisenmenger Physiology | Phase 4 | 2003-09-01 |
| Completed | Efficacy and Safety of Oral Bosentan in Patients With Idiopathic Pulmonary Fibrosis Idiopathic Pulmonary Fibrosis | Phase 2 / Phase 3 | 2003-08-01 |
| Completed | Efficacy and Safety of Oral Bosentan in Pulmonary Fibrosis Associated With Scleroderma Pulmonary Fibrosis, Scleroderma, Systemic | Phase 2 / Phase 3 | 2003-07-01 |
| Completed | The Effect of Tracleer® on Male Fertility Hypertension, Pulmonary | Phase 4 | 2003-07-01 |
| Completed | Miglustat in Niemann-Pick Type C Disease Niemann-Pick Type C Disease | Phase 2 | 2002-01-01 |
| Approved For Marketing | Individual Patient Expanded Access IND for Selexipag (Uptravi) in Participants With Non-healing Wound, Buerger Non-healing Wound, Thromboangiitis Obliterans | — | — |