NCT03816189

Role of Eosinophil in Fibrogenesis of Systemic Sclerosis

Role of Blood and Tissue Eosinophils in the Fibrogenesis of Systemic Sclerosis

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 70 (actual)
• Sponsor: University Hospital, Lille · Academic / Other
• Sex: All
• Age: 18 Years – 66 Years
• Healthy volunteers: Accepted

Summary

Eosinophils are involved in tissue remodeling and fibrosis in many inflammatory diseases. Systemic sclerosis (SSc) is an autoimmune disease with fibrotic skin and lung complications. The profibrosing properties and data from the SSc literature suggest a possible role of the eosinophils in the process of fibrogenesis of SSc.

Detailed description

it will assess the activation state of blood eosinophils in SSc patients compared to healthy controls (ECP production in vitro, surface activation markers, whole transcriptome array, ..). it will also study skin eosinophils and their recruitment (extracellular eosinophil granules, eotaxins production in skin, ..)

Conditions

• Systemic Sclerosis
• Systemic Scleroderma

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Blood test	Patients in each group will have a blood sample (9x7 mL) for eosinophils isolation, study of activation markers on whole blood and serum biomarkers testing
DIAGNOSTIC_TEST	Skin biopsies	In patients who will accept, skin biopsies will be performed in damaged and apparently normal skin, excluding fingers, hands, feet and face (biopsies are facultative)

Timeline

• Start date: 2018-10-03
• Primary completion: 2022-04-05
• Completion: 2022-04-05
• First posted: 2019-01-25
• Last updated: 2025-12-23

Locations

1 site across 1 country: France