| Not Yet Recruiting | Efficacy and Safety of Firsekibart in the Treatment of Systemic Sclerosis NCT07502105 | Tongji Hospital | N/A |
| Not Yet Recruiting | Efficacy and Safety of Allogenic Cultured Adipose-derived Mesenchymal Stromal Cell Injections on MoUth Fibrosi NCT07326033 | University Hospital, Toulouse | Phase 2 |
| Not Yet Recruiting | Characterization of Autoreactive b Lymphocytes in Autoimmune Diseases and Immune Deficiencies NCT07251179 | University Hospital, Strasbourg, France | — |
| Recruiting | Diffuse Cutaneous Scleroderma (DSSc) SFDI Study NCT07090226 | Boston University | N/A |
| Recruiting | Familial Systemic Scleroderma NCT07343115 | University Hospital, Strasbourg, France | — |
| Recruiting | Safety and Efficacy of CD19 Targeted CAR-T Therapy for Refractory Autoimmune Disease NCT06056921 | Chongqing Precision Biotech Co., Ltd | Phase 1 |
| Active Not Recruiting | Longitudinal Spatial Frequency Domain Imaging Study NCT05672992 | Boston University | N/A |
| Active Not Recruiting | Clinical Study of Divozilimab in Patients With Systemic Scleroderma NCT05726630 | Biocad | Phase 3 |
| Recruiting | TBI Using IMRT and Cyclophosphamide Prior to Stem Cell Transplant for the Treatment of Severe Systemic Scleros NCT04380831 | City of Hope Medical Center | EARLY_Phase 1 |
| Recruiting | Testing an Immunotherapy Anti-cancer Drug, Nivolumab, for Advanced Cancers in Patients With Autoimmune Disorde NCT03816345 | National Cancer Institute (NCI) | Phase 1 |
| Completed | Role of Eosinophil in Fibrogenesis of Systemic Sclerosis NCT03816189 | University Hospital, Lille | — |
| Completed | Microparticles's Role in the Pathophysiology of Systemic Lupus Erythematosus and Systemic Sclerosis NCT03575156 | University Hospital, Bordeaux | N/A |
| Unknown | BIOLOGICAL EXPLORATION OF THE VASCULAR FRACTION FROM THE ADIPOSE TISSUE OF PATIENTS WITH SCLERODERMIA NCT03629002 | Assistance Publique Hopitaux De Marseille | — |
| Unknown | Evaluation of the Serum Soluble Fractalkine as a Biomarker of Pulmonary Fibrosis in Systemic Sclerosis NCT03508375 | Assistance Publique Hopitaux De Marseille | N/A |
| Completed | Clinical and Paraclinical Characteristics of the Systemic Scleroderma Cohort According to the Criteria ACR 201 NCT03262922 | Rennes University Hospital | — |
| Completed | Trial of Topical C-82 in Systemic Sclerosis - A Phase I/II Biomarker and Safety Trial NCT02349009 | Prism Pharma Co., Ltd. | Phase 1 / Phase 2 |
| Completed | Treatment of Refractory Sever Systemic Scleroderma by Injection of Allogeneic Mesenchymal Stem Cells NCT02213705 | Assistance Publique - Hôpitaux de Paris | Phase 1 / Phase 2 |
| Terminated | Study of Pomalidomide (CC-4047) to Evaluate Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Effec NCT01559129 | Celgene | Phase 2 |
| Completed | Scleroderma Treatment With Autologous Transplant (STAT) Study NCT01413100 | Fred Hutchinson Cancer Center | Phase 2 |
| Terminated | Immunoadsorption in Patients With Severe Systemic Sclerosis NCT01410903 | GWT-TUD GmbH | N/A |
| Completed | Imatinib and Rituximab in Treating Cutaneous Sclerosis in Patients With Chronic Graft-Versus-Host Disease NCT01309997 | Lee, Stephanie | Phase 2 |
| Completed | Sildenafil Effect on Digital Ulcer Healing in sClerodErma SEDUCE STUDY NCT01295736 | University Hospital, Lille | Phase 3 |
| Terminated | Effectiveness of UVA1-irradiation in the Treatment of Early Skin Fibrosis in Patients Suffering From Systemic NCT00628797 | Nicolas Hunzelmann | Phase 1 / Phase 2 |
| Completed | CLUE Study: Connective Tissue Disease Leg Ulcer Etiology Study NCT00522002 | George Washington University | — |
| Completed | Cardiac Repercussion of Systemic Sclerodermias NCT00697736 | Hospices Civils de Lyon | N/A |
| Terminated | Placebo Controlled Trial of Bosentan in Scleroderma Patients NCT00377455 | Georgetown University | Phase 2 |
| Completed | Allogeneic Hematopoietic Cell Transplantation for Severe Systemic Sclerosis NCT00622895 | Fred Hutchinson Cancer Center | Phase 1 / Phase 2 |
| Completed | Effect of Bosentan on Skin Fibrosis in Patients With Systemic Sclerosis NCT00318175 | Heinrich-Heine University, Duesseldorf | Phase 2 |
| Completed | Cyclophosphamide and rATG With Hematopoietic Stem Cell Support in Systemic Scleroderma NCT00278525 | Northwestern University | Phase 2 |
| Completed | Effects of a Personalized Standardized Rehabilitation Program in Systemic Sclerosis NCT00318188 | Assistance Publique - Hôpitaux de Paris | N/A |
| Completed | Scleroderma Lung Disease NCT00004563 | The University of Texas Health Science Center, Houston | Phase 3 |
| Withdrawn | Low-Dose Conditioning Followed by Donor Stem Cell Transplant in Treating Patients With Severe Systemic Scleros NCT01047072 | Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium | Phase 2 |