NCT04118725

Muscular Respiratory Involvement and Systemic Sclerosis

Assessment of Muscular Respiratory Involvement in Systemic Sclerosis

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 52 (actual)
• Sponsor: Poitiers University Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Dyspnea in systemic sclerosis (ScS) constitute a major factor of functional disability. Intensity of dyspnea is sometimes discordant with objectives data from cardiopulmonary involvements, suggesting unknown additional factors. Diffuse fibrosing myopathy of bad prognosis have been reported in ScS.To now, muscular respiratory involvement has not been evaluated in ScS. Therefore, ScS patients (with or without dyspnea) could have underlying respiratory muscular involvement not detected by current standard of care with pulmonary function tests (PFT). This project is the first, to the best of our knowledge, to assess frequency of respiratory muscular involvement in ScS and to evaluate a screening strategy of this involvement.

Conditions

• Systemic Sclerosis
• Diaphragm Defect
• Respiratory Insufficiency
• Pulmonary Function Test
• Diaphragmatic Electromyography
• Muscular Weakness

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Pulmonary function test	Diaphragmatic electromyography with measurement of transdiaphragmatic pressure in cases of dyspnea and/or abnormal pulmonary function test (maximum inspiratory pressure and/or lying/seating low vital capacity ratio)

Timeline

• Start date: 2019-10-21
• Primary completion: 2021-07-07
• Completion: 2021-07-07
• First posted: 2019-10-08
• Last updated: 2021-09-29

Locations

1 site across 1 country: France