NCT03340194

Evaluation of Calcinosis in Systemic Sclerosis

Evaluation of Calcinosis Prevalence in Systemic Sclerosis : a Cross Sectional Study Evaluating Calcinosis Cutis Prevalence by Hand and Feet Radiographic Assessment in Systemic Sclerosis Patients and Study Their Correlation With Organ Injury

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 214 (actual)
• Sponsor: University Hospital, Lille · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Systemic sclerosis is a rare pathology characterized by fibrosis and vascular lesion with skin, pulmonary, digestive and cardiac localisation. Calcinosis cutis is commonly described, but its prevalence and appear few documented in literature. Moreover, this studies used clinical observation to determine presence or absence of calcification, and rarely radiography, in particular for feet localisation. In the same way, skin calcification and organ injury association appear unclear. The aim of the study is firstly to determine prevalence of calcinosis cutis, with hand and feet radiography realisation in a cohort of systemic sclerosis patient. Secondly, will be determine the correlation between calcinosis and organ injury.

Conditions

• Systemic Sclerosis

Interventions

Type	Name	Description
RADIATION	Radiography	Radiography of the hand and feet (face incident) the day of the inclusion
PROCEDURE	Veinous punction	Blood sample to analysis VEGF, endothelin 1, endostatin and P/GF, (ELISA method)

Timeline

• Start date: 2017-11-30
• Primary completion: 2019-05-14
• Completion: 2021-04-02
• First posted: 2017-11-13
• Last updated: 2025-12-05

Locations

1 site across 1 country: France