NCT02562079

Vasculopathy, Inflammation and Systemic Sclerosis

Vasculopathy, Inflammation and Systemic Sclerosis: The Role of Endothelial Cell Activation and OX40/OX40L in Modulation of T Lymphocyte Activation

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 350 (actual)
• Sponsor: University Hospital, Bordeaux · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

It is a study of basic research with mechanistically objectives and including clinical biological samples.

Detailed description

Systemic sclerosis (SSc) is a rare and severe disease characterised by a fibrotic process and an incompletely elucidate physiopathology. Several shared featured have been identified between SSc and another autoimmune disease, the systemic lupus erythematous (SLE) as an interferon-alpha signature, the role of platelets and the polymorphism of OX40 ligand (OX40L). In SLE, OX40L has been shown highly linked to the active form of the disease, was increased by the CD40L of platelets and induced the CD8 cytotoxicity while inhibiting the suppressive functions of regulator T lymphocytes. The third main factor of the SSc physiopathology apart from autoimmunity and fibrosis is the vasculopathy with an important role of endothelial cells (EC). They turned out to be half-professional antigen presenting cells and can modulate the adaptive immunity.

Conditions

• Systemic Sclerosis

Interventions

Type	Name	Description
BIOLOGICAL	Blood samples	* biological features of the standard follow-up * 2 more blood tube for the biological collection (serum and PBMC)
BIOLOGICAL	Biopsy	Skin biopsies

Timeline

• Start date: 2012-03-01
• Primary completion: 2016-12-01
• Completion: 2016-12-01
• First posted: 2015-09-29
• Last updated: 2017-04-07

Locations

1 site across 1 country: France