NCT04995588

Systemic Sclerosis and Innate T Cells

Role of Innate T Cells in Physiopathology of Systemic Sclerosis

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 240 (estimated)
• Sponsor: Poitiers University Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Innate T cells (ITC) are decreased in systemic sclerosis (SS) and an early lymphocyte innateness has been reported. In the other part, ITC are implicated on inflammatory process, including the IL-33/ST2 axis, which is also involved in ScS endotheliopathy. Data are however scarce and physiopathological mechanisms have not been assessed to date. The investigators hypothesize a global lymphocyte innateness in SSc, linked to a chronic ITC stimulation by innate signals leading to ITC exhaustion, and their potential role in endotheliopathy and fibroblast activation in SSc.

Conditions

• Systemic Sclerosis

Interventions

Type	Name	Description
OTHER	Blood test	Unique blood draw of 45mL for all the participants

Timeline

• Start date: 2022-02-28
• Primary completion: 2025-08-28
• Completion: 2026-01-28
• First posted: 2021-08-09
• Last updated: 2024-06-10

Locations

1 site across 1 country: France