NCT03531216

Topical Rosemary Oil Application in Systemic Sclerosis

Psychophysiological Effect of Local Rosemary and Olive Oil Application Onto the Hands of Patients With Systemic Sclerosis - a Prospective Crossover, Open-label, Nonrandomized Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 12 (actual)
• Sponsor: ARCIM Institute Academic Research in Complementary and Integrative Medicine · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The objectives of this prospective crossover, open-label, nonrandomized study are to estimate effect sizes of vasodilatation and sense of warmth after application of topical rosemary essential oil in patients suffering from systemic sclerosis.

Detailed description

In a crossover design, patients suffering from systemic sclerosis (12 subjects) receive applications of olive oil and of 10% Rosmarinus officinalis L. (rosemary) essential oil to both hands with a wash-out period of 3 hours. Effects on vasodilatation are measured with infrared thermography. Patients' sense of warmth is assessed by the "Herdecke warmth perception questionnaire". Measurements take place at baseline and 45 minutes following the interventions (pre-post-comparison). To determine within and between-differences, 2-sample t-tests will be used and effect sizes will be calculated (Standardized Effect Size).

Conditions

• Systemic Sclerosis

Interventions

Type	Name	Description
OTHER	Rosemary essential oil	Topically-applied oil to both dorsal and palmar aspects of the hands
OTHER	Placebo	Topically-applied oil to both dorsal and palmar aspects of the hands

Timeline

• Start date: 2015-11-02
• Primary completion: 2016-03-21
• Completion: 2016-03-21
• First posted: 2018-05-21
• Last updated: 2019-01-10

Locations

2 sites across 1 country: Germany