| Suspended | Efficacy of Para-Tyrosine Supplementation on the Survival and Clinical Outcome in Patients With Sepsis NCT03278730 | University of Pecs | Phase 2 |
| Not Yet Recruiting | Alveolar Dead Space as Predictor of Organ Failure in Severe Sepsis NCT01315782 | The University of Texas Health Science Center, Houston | — |
| Not Yet Recruiting | Extended vs. Intermittent Beta-Lactam Infusion in ICU Sepsis NCT07398703 | Assiut University | — |
| Not Yet Recruiting | Blood Purification in Septic Children NCT05595239 | Children's Hospital of Fudan University | N/A |
| Not Yet Recruiting | Individualized Multiplex Pathophysiological Treatment of Severe Acute Infections: N-Acetylcysteine NCT07273071 | Theis S. Itenov | Phase 4 |
| Not Yet Recruiting | Vascular Events in Noncardiac Surgery Patients Cohort Evaluation Study 2 NCT07300579 | Hamilton Health Sciences Corporation | — |
| Not Yet Recruiting | Comparison of Sepsis Prediction Algorithms NCT05943938 | Emory University | — |
| Not Yet Recruiting | Saudi Emergency Laparotomy Audit NCT07429929 | King Faisal Specialist Hospital & Research Center | — |
| Not Yet Recruiting | Recovery of Physical Function After Critical Illness In Older Adults NCT07225257 | University of Kentucky | — |
| Not Yet Recruiting | Surgical Critical Care Initiative (SC2i) Tissue and Data Acquisition Protocol (TDAP) in Burn Patients Improvin NCT07249762 | Henry M. Jackson Foundation for the Advancement of Military Medicine | — |
| Not Yet Recruiting | TDAP in Burn Patients (Group 2) NCT07223684 | Henry M. Jackson Foundation for the Advancement of Military Medicine | — |
| Not Yet Recruiting | Adaptive Platform Trial for Personnalisation of Sepsis Treatment in Children and Adults: a Multi-national, Tre NCT06381661 | Assistance Publique - Hôpitaux de Paris | Phase 2 |
| Not Yet Recruiting | Nogapendekin Alfa-Inbakicept and iNKT Cells for Critically Ill Adults With Severe Community-Acquired Pneumonia NCT07492888 | ImmunityBio, Inc. | Phase 2 |
| Not Yet Recruiting | Study of Nogapendekin Alfa Inbakicept and iNKT Cells in Critically Ill Adults With Severe Community-Acquired P NCT07492875 | ImmunityBio, Inc. | Phase 3 |
| Not Yet Recruiting | Cardiovascular Phenotypes in Sepsis NCT07442032 | Karolinska Institutet | — |
| Recruiting | Infraclavicular Axillary Vein Collapsibility Index as a Predictor of Fluid Responsiveness NCT07507877 | Ain Shams University | — |
| Withdrawn | Electronic Health Record-Integrated Patient-Generated Data NCT06668870 | Wake Forest University Health Sciences | N/A |
| Not Yet Recruiting | Nafamostat Mesylate Versus Regional Citrate Anticoagulation for Continuous Renal Replacement Therapy in Sepsis NCT07518303 | Jianfeng Xie | Phase 4 |
| Not Yet Recruiting | Hemodynamic Venous Congestion Ultrasound (VExUS) by ICU Nurses in Sepsis Patients. NCT07406750 | Region Örebro County | — |
| Recruiting | Vancomycin and Acute Kidney Injury in Sepsis Treatment - Intervention NCT07084129 | Children's Hospital of Philadelphia | Phase 1 |
| Not Yet Recruiting | Racecadotril for Organ Injury in Sepsis Patients NCT07454421 | Zhujiang Hospital | Phase 1 / Phase 2 |
| Not Yet Recruiting | UMMS Sepsis Early Prediction Score (SEPSys) and RESCUE Score Combined Clinical Trial NCT06779617 | University of Maryland, Baltimore | N/A |
| Not Yet Recruiting | Corticosteroids in Hyperinflammatory Phenotype of Critical Illness NCT07511582 | Bin Du | Phase 2 |
| Not Yet Recruiting | Aminoglycosides in Early Sepsis NCT06712641 | University Hospital, Akershus | Phase 4 |
| Recruiting | Immunothrombosis With Septic Shock Undergoing Renal Replacement Therapy With the OXIRIS Membrane NCT06440317 | University Hospital, Bordeaux | — |
| Not Yet Recruiting | A Study to Compare the Efficacy and Safety of Extended and Intermittent Infusion of Beta-lactams in Critically NCT07484633 | Semmelweis University | Phase 4 |
| Not Yet Recruiting | Biomarker-enhanced Artificial Intelligence Based Pediatric Sepsis Screening Tool NCT05311046 | Computer Technology Associates, Inc. | — |
| Not Yet Recruiting | Adjunctive Fludrocortisone in Septic Shock NCT07451886 | Chinese University of Hong Kong | Phase 2 |
| Not Yet Recruiting | STeroids and Enhanced Spectrum Antibiotics for the Treatment of Patients in Africa With Refractory Sepsis NCT07332325 | University of Virginia | Phase 3 |
| Not Yet Recruiting | MULTIMODAL APPROACH IN THE DIAGNOSIS OF SEPTIC AKI NCT07472452 | Ankara Etlik City Hospital | — |
| Not Yet Recruiting | Call for Life Sepsis NCT07407868 | Makerere University | N/A |
| Not Yet Recruiting | Early Dexmedetomidine and Sympathetic Regulation in Sepsis NCT07470775 | Sichuan Academy of Medical Sciences | Phase 4 |
| Not Yet Recruiting | The Extended Study of Prevalence of Infection in Intensive Care IV NCT07309549 | Universidad de la Sabana | — |
| Not Yet Recruiting | Implementation of Timely Management of Sepsis and Septic Shock Protocol in the Emergency Department and Intens NCT07460024 | Al-Azhar University | N/A |
| Recruiting | OxiCLEAR (Oxiris Cytokines and Endotoxin Adsorption Rate) Study NCT07419802 | Pauls Stradins Clinical University Hospital | — |
| Not Yet Recruiting | Early Biological and Mechanical Profiling in Sepsis-Associated ARDS NCT07281911 | Hospital Universitari Vall d'Hebron Research Institute | — |
| Not Yet Recruiting | Curcumin in Critically Ill Patients With Sepsis NCT07436130 | Hospital Civil de Guadalajara | N/A |
| Not Yet Recruiting | Role of RNA Metabolism Alterations in Persistent Immune Dysfunction After Sepsis NCT07418801 | Assistance Publique - Hôpitaux de Paris | — |
| Recruiting | Assessing Immune Dysfunction in Sepsis NCT07154615 | University of Minnesota | — |
| Not Yet Recruiting | Long-term Assessment of Patients Treated in the ICU for Sepsis NCT07502794 | Hospital Israelita Albert Einstein | — |
| Not Yet Recruiting | Modified Shock Index NCT07479563 | Sohag University | — |
| Not Yet Recruiting | Cohort Study of Chronic Liver Disease Complicated by Sepsis NCT07465003 | The Second Affiliated Hospital of Chongqing Medical University | — |
| Recruiting | African Survey on Sepsis Knowledge (ASK) NCT07351344 | Claudia Spies | — |
| Recruiting | Accuracy and Safety of the Syai Tag System for Continuous Glucose Monitoring in Intensive Internal Care Unit NCT07448805 | University Medical Centre Maribor | N/A |
| Recruiting | Gelaspan vs Crystalloid Therapy in Sepsis NCT07172451 | Shanghai Zhongshan Hospital | Phase 4 |
| Recruiting | A Study to Investigate the Efficacy, Safety, and Tolerability of AZD4144in Participants With Sepsis-associated NCT07215702 | AstraZeneca | Phase 2 |
| Recruiting | Efficacy and Safety of YD0743 Treatment for Sepsis-Associated ARDS NCT07413094 | Shanghai Yidian Pharmaceutical Technology Development Co., Ltd. | Phase 2 |
| Not Yet Recruiting | Peripheral Perfusion and Outcomes in ICU Patients With Sepsis NCT07391098 | Alexandra Elena Lazăr | — |
| Recruiting | Neonatal Enterovirus Infections in Italy: Virological Characterization, Genomic and Clinical-epidemiological I NCT07356583 | Fondazione IRCCS Policlinico San Matteo di Pavia | — |
| Not Yet Recruiting | Labile Iron Removal by Adding the Iron Chelator MEX-CD1 to Dialysate in Sepsis-Associated Acute Kidney Injury NCT07236463 | Centre Hospitalier Universitaire de Nīmes | Phase 1 / Phase 2 |
| Not Yet Recruiting | Early Sepsis Recognition Tool NCT07397689 | KK Women's and Children's Hospital | — |
| Not Yet Recruiting | The Caribbean Registry of Extracorporeal Membrane Oxygenation (ECMO) From the University Hospital in Martiniqu NCT07351435 | University of Genova | — |
| Not Yet Recruiting | Written Sepsis Education for Patients NCT07415096 | McMaster University | N/A |
| Completed | ICU Admission Diagnoses and ICU Mortality NCT07369206 | Ataturk University | — |
| Not Yet Recruiting | Mechanisms of Prognostic Regulation andPrecision Phenotype Ldentification in Severe Infections Driven by Speci NCT07353970 | Second Affiliated Hospital of Wenzhou Medical University | — |
| Not Yet Recruiting | Validation of SOFA-2 for Mortality and Sepsis-3 Prevalence in Turkey NCT07300306 | Marmara University | — |
| Recruiting | BLOOM: Pragmatic Feasibility Trial NCT07287332 | Mayo Clinic | N/A |
| Not Yet Recruiting | Mechanisms of Precise Immune Cell Phenotyping and Prognostic Prediction in Severe Infection NCT07332793 | Second Affiliated Hospital of Wenzhou Medical University | — |
| Recruiting | External Drainage of Thoracic Duct Lymph to Reduce Inflammatory Cytokines in Septic Shock Patients NCT04855786 | University of Pennsylvania | N/A |
| Not Yet Recruiting | Early Norepinephrine Administration and Rapid Dose Adjustment NCT07343206 | Siriraj Hospital | N/A |
| Not Yet Recruiting | MyokinE100 System: Closed Loop Electrical Muscle Stimulation to Mitigate ICU Acquired Weakness in Medical ICU NCT07362862 | Health Discovery Labs | N/A |
| Not Yet Recruiting | Point-of-Care AI Assistance and Critical Care Outcomes: A Randomized Trial NCT07293078 | MetroWest Artificial Intelligence Research Workgroup | Phase 1 / Phase 2 |
| Not Yet Recruiting | Accelerating Recovery After ICU Admission: Post-discharge Supplementation With Pasteurized Akkermansia Mucinip NCT07295353 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | N/A |
| Not Yet Recruiting | Early Optimization of Ceftazidime Regimen in Critical Care NCT07085624 | Centre Hospitalier Universitaire de Saint Etienne | N/A |
| Enrolling By Invitation | Necrotizing Soft Tissue Infections NCT07107555 | European Society for Trauma and Emergency Surgery | — |
| Active Not Recruiting | İntensive Care Sepsis Prevelance in Turkey (INSEP-TURK) NCT07283588 | Gulhane Training and Research Hospital | — |
| Withdrawn | Mitochondrial Dysfunction Contributes to Sepsis Induced Cardiac Dysfunction NCT05148117 | University of Alabama at Birmingham | — |
| Enrolling By Invitation | Evaluating Artificial Intelligence-Based Clinical Decision Support for Sepsis and ARDS NCT07025096 | University of Pennsylvania | N/A |
| Not Yet Recruiting | OPT101 in Patients With Community Acquired Pneumonia (CAP) With Sepsis NCT06669403 | Op-T LLC | Phase 1 |
| Recruiting | Febrile Infants Swedish Study NCT07134751 | Region Skane | — |
| Completed | Systemic Immune-Inflamation Index and Mortality in ICU Patients NCT07493759 | Ataturk University | — |
| Recruiting | Evaluation of Pediatric eCART Implementation NCT06771830 | University of Wisconsin, Madison | N/A |
| Recruiting | Safe and Explainable AI NCT06694181 | Abramson Cancer Center at Penn Medicine | — |
| Recruiting | Sepsis-associated Thrombocytopenia and Platelet Transfusion （STAPT） NCT07230067 | Nanfang Hospital, Southern Medical University | — |
| Recruiting | KInetics of Procalcitonin to Reduce Unnecessary aNtibiotic Use - Comparing Procalcitonin Kinetics-guided and A NCT07211620 | Semmelweis University | N/A |
| Recruiting | A Study on How the Immune System Responds to Sepsis and Its Long-term Effects NCT07273344 | Radboud University Medical Center | — |
| Not Yet Recruiting | Study of Protection And Repair of Endothelial-glycocalyx in Sepsis NCT07160426 | Beth Israel Deaconess Medical Center | Phase 2 |
| Not Yet Recruiting | Normal Saline Versus Ringer's Lactate for Initial Fluid Resuscitation in Sepsis NCT07240701 | Egemen Yildiz | Phase 4 |
| Not Yet Recruiting | Risk Factors and Clinical Outcomes of Neonatal Anemia in NICU NCT07188298 | Assiut University | — |
| Not Yet Recruiting | Predictive Model for Multidrug Resistance in Patients Admitted to the Emergency Department With Sepsis NCT07167173 | Hospital Italiano de Buenos Aires | — |
| Recruiting | AN69ST Verse PS in CBP in Septic Children NCT05692011 | Children's Hospital of Fudan University | — |
| Recruiting | ACOD1 as a Prognostic Marker for Sepsis NCT07533994 | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | — |
| Recruiting | PIVO Use for Blood Cultures in the Emergency Department NCT07348289 | Intermountain Health Care, Inc. | — |
| Not Yet Recruiting | Evaluation of the Dialytic Clearance of the Combination of Peracillin and Tazobactam NCT07167524 | University Hospital, Rouen | — |
| Not Yet Recruiting | Nucleosome Monitoring Relevance for Outcome Prediction in Critically Ill Patients NCT07184593 | Erasme University Hospital | — |
| Not Yet Recruiting | Effect of Dapagliflozin on Interleukin 10 in Sepsis NCT07206160 | Minia University | — |
| Recruiting | ARTICE® Real Data Collection & Observational Trial, Phase 4 Study NCT07388628 | Artcline GmbH | — |
| Recruiting | Hemodynamic Evaluation Using Microcirculation for Early Treatment of Septic Patients NCT06910891 | University Hospital, Limoges | N/A |
| Completed | Novel Sepsis Sub-phenotypes Based on Trajectories of Vital Signs NCT05826223 | Emory University | — |
| Not Yet Recruiting | IVC Collapsibility Index or CVP as a Predictor of Fluid Responsiveness in Pediatric Sepsis NCT06833333 | Tanta University | N/A |
| Recruiting | Fluid Management and Individualized Resuscitation in Sepsis NCT07009665 | University Medical Center Groningen | N/A |
| Not Yet Recruiting | Investigating the Impact of Sepsis Phenotypes on Antibiotic Treatment in Patients With Severe Pneumonia and Se NCT06977165 | University of Manchester | — |
| Not Yet Recruiting | Transcriptional Analysis of Mechanisms in Liver Failure and Sepsis NCT07131969 | University of Cambridge | — |
| Not Yet Recruiting | A Validation Study on a Prognostic Prediction Model for Respiratory Tract Infections NCT07109310 | Peking Union Medical College Hospital | — |
| Not Yet Recruiting | Clinical Performance Study of Microbio InfectID-BSI for Detection of Bacteria and Yeast With Patient Blood Sam NCT06531031 | Microbio Co Ltd | — |
| Not Yet Recruiting | Candidemia in Critically Ill Patients NCT06929494 | Meir Medical Center | — |
| Not Yet Recruiting | Organ Dysfunction Score for Obstetric Patients NCT07068022 | Daniela Vasquez | — |
| Not Yet Recruiting | Effect of Xuebijing InjecTion on Outcomes in Sepsis Patients Under Real-World Conditions（EXIT-SEP REAL） NCT07069894 | Southeast University, China | — |
| Not Yet Recruiting | "Mini Fluid Challenge Assessment: a Comparison Among Three Hemodynamic Tools" NCT04934943 | Humanitas Clinical and Research Center | — |
| Not Yet Recruiting | Outcomes of Sepsis Patients in China (CHINA-SEP) NCT07066553 | Southeast University, China | — |
| Recruiting | Sepsis and Hospital Mortality NCT07022041 | University of Calabria | — |
| Recruiting | The RightCall: Implementing a Sepsis Diagnostic Toolkit to Improve Pediatric Diagnosis in ED Transfer Calls NCT07051668 | University of Colorado, Denver | N/A |
| Recruiting | Limited Versus Extended Trophic Feeding (LET-FEED) Trial NCT06893939 | University of Washington | Phase 3 |
| Recruiting | Virtual Reality in ICU - PARTNER NCT06876168 | Kirby Mayer | — |
| Not Yet Recruiting | Safety, Tolerability and Performance of the NucleoCapture Device in the Reduction of Circulating CfDNA/NETs in NCT05647096 | Santersus AG | N/A |
| Not Yet Recruiting | PCT Guided Antibiotics Use in Critically Ill Adult Patients in China NCT06945510 | China-Japan Friendship Hospital | N/A |
| Recruiting | Empirical Meropenem Versus Piperacillin/Tazobactam for Adult Patients With Sepsis NCT06184659 | Scandinavian Critical Care Trials Group | Phase 4 |
| Not Yet Recruiting | Comparison of Short Peptide and Whole Protein Formula in the Early Enteral Nutrition of Patients With Sepsis NCT07038057 | Shanghai Zhongshan Hospital | N/A |
| Completed | Prophylactic Noradrenaline Infusion and Its Impact on Post-induction Hypotension NCT07022730 | Cairo University | N/A |
| Recruiting | Immune Responses to Dengue and Sepsis NCT07040202 | Institut Pasteur du Cambodge | — |
| Not Yet Recruiting | Ultrasound-guided Blood Sampling Drawing for Microbiological Analysis in the Critically Ill NCT06156072 | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | — |
| Recruiting | Human Umbilical Cord Mesenchymal Stem Cells Treatment in Sepsis NCT06882811 | Daping Hospital and the Research Institute of Surgery of the Third Military Medical University | EARLY_Phase 1 |
| Not Yet Recruiting | IL-40 and IL-41 Levels in Sepsis, Septic Shock, and Healthy Individuals NCT06963541 | Melahat Yalcin Solak | — |
| Not Yet Recruiting | This is an Observational Study That Aims to Demonstrate Postoperative Risk Factors in Pediatric Cardiac Surger NCT06985082 | Instituto de Cardiologia do Rio Grande do Sul | — |
| Enrolling By Invitation | Can Gdf-15 Level Predict Progression to Multiple Organ Failure in Patients With Septic Shock NCT06808100 | Ankara City Hospital Bilkent | — |
| Not Yet Recruiting | The Impact of Selective Vitamin D Receptor Activation on Clinical Outcomes in Septic Patients NCT06209268 | University of Split, School of Medicine | N/A |
| Not Yet Recruiting | Adult MDW Dual Cut-Off Accuracy Study NCT06885528 | Beckman Coulter, Inc. | — |
| Recruiting | Presepsin Diagnostic Performance in Severe Burn Sepsis NCT07060560 | Dohern Kym | — |
| Recruiting | Early Versus Late Adjunctive Vasopressin in Septic Shock NCT06709573 | The Cleveland Clinic | Phase 4 |
| Not Yet Recruiting | Shenfu Injection Modulates Carotid Elasticity in Septic Shock NCT06915506 | First Affiliated Hospital of Wannan Medical College | Phase 4 |
| Completed | The Effect of CUGP Fluid Management in Patients With Sepsis or Septic Shock NCT06879249 | Shusheng Li | N/A |
| Not Yet Recruiting | Novel Biomarkers Related Xuebijing Injection Improves Sepsis NCT06920420 | Southeast University, China | — |
| Recruiting | Characterization and Longitudinal Monitoring of Muscular Phenotype in Patients Admitted to Intensive Care for NCT07074028 | Centre Hospitalier de Saint-Brieuc | N/A |
| Recruiting | Dynamics of Organ Damage and Immune Exhaustion During Sepsis NCT06817408 | Mayo Clinic | — |
| Active Not Recruiting | Emapalumab Treatment For Anticipated Clinical Benefit In Sepsis Driven By The Interferon-Gamma Endotype (The E NCT06694701 | Hellenic Institute for the Study of Sepsis | Phase 2 |
| Completed | Use of Lactate-to-Albumin, CRP-to-Albumin, and Procalcitonin-to-Albumin Ratios to Predict Mortality in ICU Pat NCT07242027 | Medical University of Silesia | — |
| Recruiting | Identification of Markers of Poor Clinical Prognosis in Sepsis by Epigenetic Analysis NCT06446947 | Assistance Publique Hopitaux De Marseille | — |
| Recruiting | A Study to Learn About How Safe BAY 3389934 is, Its Suitable Dose, and How it Affects the Participants With Se NCT06854640 | Bayer | Phase 1 |
| Recruiting | Efficacy of SGLT2 Inhibitors in Adults With Sepsis NCT06473844 | Hospital Authority, Hong Kong | N/A |
| Not Yet Recruiting | Prognostic Value of Right Ventricular-pulmonary Arterial Coupling Assessed by Echocardiography in Septic Patie NCT06887140 | University Medical Center Ho Chi Minh City (UMC) | — |
| Not Yet Recruiting | SOFA Score with Serum Procalcitonin Versus SOFA Score with Neutrophil/lymphocyte Ratio in Predicting Sepsis an NCT06847477 | Ain Shams University | — |
| Not Yet Recruiting | Neonatal Comfort Seat Allowing Safe Lumbar Puncture and Minimizing Failure: a Randomized Controlled Trial NCT06811428 | Joel Cox | N/A |
| Completed | Analysis of Risk Factors and Prognostic Predictive Value in Sepsis Patients With Nutritional Risk NCT07278167 | The Affiliated Hospital of Inner Mongolia Medical University | — |
| Recruiting | Defining Volume Status in Sepsis With Extracellular Water Measurement NCT06512129 | Uppsala University | — |
| Recruiting | Transcutaneous Auricular Vagus Nerve Stimulation as Adjuvant Treatment for Sepsis Patients NCT07051694 | Third Military Medical University | N/A |
| Not Yet Recruiting | Hyperinflammation and Hyperferritinemia in Critically Ill Patients NCT06820905 | Charles University, Czech Republic | — |
| Recruiting | Role of Transposable Elements in Septic Immune Aging NCT06809868 | University of California, San Francisco | — |
| Recruiting | Efficacy and Safety of Electroacupuncture for ICU Sepsis Patients NCT06666946 | Shusheng Li | N/A |
| Not Yet Recruiting | Ventriculo-arterial Coupling and Myocardial Work in Sepsis and Septic Shock NCT06853574 | General and Teaching Hospital Celje | N/A |
| Recruiting | Stop Sepsis Through Home Monitoring Cooperative NCT06920979 | University Hospital, Antwerp | N/A |
| Recruiting | The Effects of Endotracheal Suctioning on Pain and Serum Markers NCT06692400 | Loma Linda University | N/A |
| Recruiting | Evaluation of Blood Protein O-GlcNAcylation Levels in Children NCT06754696 | Nantes University Hospital | — |
| Recruiting | Renin Levels as Prognostic Indicators of Septic Shock Severity and Outcome NCT06545838 | Federal Research and Clinical Centre of Intensive Care Medicine and Rehabilitology | — |
| Completed | A Study to Learn About the Occurrence of Disseminated Intravascular Coagulation in People With Sepsis and Furt NCT06986798 | Bayer | N/A |
| Recruiting | Clean Trial - Chlorination to Reduce Enteric and Antibiotic Resistant Infections in Neonates NCT06824350 | University of California, Berkeley | N/A |
| Recruiting | Comparison Between Interleukin 6 and Procalcitonin in Detecting Sepsis and Incidence of Mortality in Burn ICU NCT06915974 | Ain Shams University | N/A |
| Active Not Recruiting | An Observational Study in the United States to Learn How Venous Thromboembolism, Disseminated Intravascular Co NCT06765681 | Bayer | — |
| Recruiting | Beta-Lactam Antibiotics InitiaL ExpoSure OptimisEd in CriticallY Ill Patients with SEpsis NCT06766461 | Erasmus Medical Center | Phase 4 |
| Recruiting | Peripheral Perfusion Index-guided Fluid Resuscitation for Preventing Acute Skin Failure in Elderly Critically NCT07367113 | Ying Wang | N/A |
| Enrolling By Invitation | Effect of Remazolam Besylate Combined With Remifentanil Analgesic Sedation on the Prognosis of Patients With S NCT06731088 | First Affiliated Hospital of Ningbo University | Phase 4 |
| Active Not Recruiting | A Rapid Diagnostic of Risk in Hospitalized Patients Using Machine Learning NCT05893420 | AgileMD, Inc. | N/A |
| Recruiting | The Gut Microbiome - Source of Sepsis and Novel Target in Intensive Care Units? NCT06749483 | Jena University Hospital | — |
| Completed | Validation of the Accuracy of a Novel POCT Dry Blood Gas Analyzer in Acute Care Settings NCT06726473 | Zhujiang Hospital | — |
| Not Yet Recruiting | Venous Excess Ultrasound for Personalized Resuscitation in Septic Shock NCT06696391 | Western University, Canada | Phase 3 |
| Recruiting | Changes in Host Gene Expression to Differentiate Between Systemic Inflammation and Infection After Major Surge NCT06116656 | St. Antonius Hospital | — |
| Recruiting | Prediction of Mortality and Morbidity After Hip Fracture Using Monocyte Distribution Width (MDW) NCT07350785 | National and Kapodistrian University of Athens | — |
| Not Yet Recruiting | Investigation of Novel and Established Therapies in a Human Intravenous Lipopolysaccharide Model of Sepsis NCT06626984 | Belfast Health and Social Care Trust | Phase 1 / Phase 2 |
| Recruiting | Effect of Albumin Replacement on Oxygen Delivery in Sepsis Patients NCT06556914 | Samsun University | — |
| Recruiting | Use of Epoetin Alfa and Iron Derisomaltose in Treatment of Anemia in Patients With Sepsis or Septic Shock: a R NCT06670963 | Piotr Czempik | Phase 4 |
| Recruiting | Improving Therapeutic Drug Monitoring and Dosing for Vancomycin in Young Infants With Infections (VANCAPP) (Pa NCT05770622 | Murdoch Childrens Research Institute | Phase 4 |
| Recruiting | TriVerity™ for Improved Management of Emergency Department (ED) Patients With Suspected Infections NCT06637904 | Inflammatix | N/A |
| Not Yet Recruiting | Quantitative Ultrasound Assessment of Abdominal Cavity Space NCT06634732 | Ruijin Hospital | — |
| Recruiting | Effects of Enteral Nutrition Content on Disease Progression in Sepsis Patients NCT06943326 | Inonu University | — |
| Recruiting | Viscoelastic Coagulation for Early Sepsis Detection NCT07073456 | Hellenic Institute for the Study of Sepsis | — |
| Recruiting | Immunomodulatory Effects of Dexamethasone, Tocilizumab and Anakinra During Experimental Human Endotoxemia NCT06624436 | Radboud University Medical Center | Phase 4 |
| Completed | Clearance of Antibacterial Agents During Hemoperfusion in Patients With Sepsis NCT06602245 | Efferon JSC | — |
| Recruiting | NeoDoppler: New Ultrasound Technology for Continuous Monitoring of Cerebral Circulation Pilot NCT06646250 | St. Olavs Hospital | — |
| Completed | Alpha-lipoic Acid in Critically Ill Patients With Sepsis NCT06661993 | Damanhour University | N/A |
| Completed | Role of Enteral Lactoferrin as an Adjuvant for Prevention of Sepsis Among Preterm Neonates NCT07480434 | Zartash Sial Paeds Med | Phase 1 |
| Withdrawn | Use of Antibiotic Based Irrigation for Ureteroscopic Treatment of Urolithiasis NCT06007352 | Yale University | Phase 2 |
| Recruiting | The Effect of Dexmedetomidine on the Renal Functions in Septic Critically Ill Patients NCT06570187 | Cairo University | Phase 4 |
| Not Yet Recruiting | CRP,CRP/Alb Ratio, N/L Ratio in Predictors of Both Systemic Infection and Survival in Patient With Sepsis in A NCT06586372 | Assiut University | — |
| Completed | Serum Albumin Ratios Can Improve Sepsis Mortality Prediction NCT06640504 | Benha University | — |
| Recruiting | Efficacy and Safety of Cytokine Adsorption and Plasma Exchange in Patients With ACLF and Sepsis NCT06562803 | Third Affiliated Hospital, Sun Yat-Sen University | N/A |
| Not Yet Recruiting | Sensitivity and Specificity of Leucocytes Subpopulation Versus Platelet Indices in Prediction of Clinical Outc NCT06612307 | Minia University | — |
| Recruiting | Blood DdPCR for Early Identification and Dynamic Surveillance of Pathogenic Bacteria in ICU Septic Patients: a NCT06791889 | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | — |
| Recruiting | A Comparative Study Between Neutrophil/Lymphocyte Ratio and Lactate/Albumin Ratio as Predictive Inflammatory M NCT07089524 | Ain Shams University | — |
| Completed | Does the Phoenix Pediatric Sepsis Prognosis Prediction Scale Work NCT06539884 | Oguz Dursun | — |
| Withdrawn | Sepsis Pre-Alert Monitoring Intervention: Study to Investigate Targeted Enhanced Monitoring for Sepsis NCT03473769 | NYU Langone Health | N/A |
| Unknown | Process Mapping and Data Collection to Inform a Computer Simulation Model of Hospitalised Patients With Bloods NCT06271031 | Liverpool University Hospitals NHS Foundation Trust | — |
| Completed | Host Dysregulation-Driven Sepsis Prediction Model NCT06523075 | Second Affiliated Hospital of Wenzhou Medical University | — |
| Recruiting | A Phase III, Open Label, Randomized, Controlled Study of VBI-S in the Treatment of Hypovolemia in Patients Wit NCT06072430 | Vivacelle Bio | Phase 3 |
| Completed | Inferior Vena Cava Collapsibility and Distensibility Assessment in Critical Care. NCT06516692 | Jinnah Postgraduate Medical Centre | N/A |
| Recruiting | Observational Study About the Use of Perfusion Index to Use Vasopressor in Sepsis NCT06860438 | Ain Shams University | — |
| Enrolling By Invitation | Impact of the Introduction of a Performance Improvement Program on the Initial Management of Sepsis and Septic NCT06657625 | University Hospital, Brest | — |
| Recruiting | Comparing Super High-flux and High-flux Dialyzer Performance Among Hemodialysis Patient With Sepsis : a Random NCT06989892 | Navamindradhiraj University | N/A |
| Recruiting | The APS Phenotyping Study NCT06521502 | Vanderbilt University Medical Center | — |
| Recruiting | Characterisation of Endothelial Cells in Different Inflammatory Pathologies NCT06613256 | Royal Surrey County Hospital NHS Foundation Trust | — |
| Not Yet Recruiting | Early Resuscitation in Paediatric Sepsis Using Inotropes NCT06478797 | NATALIA LOPERA MUNERA | Phase 2 |
| Recruiting | Evidence-based Evaluation and Mechanism of Shenhuang Granules in the Treatment of Sepsis NCT06514339 | The First Affiliated Hospital of Zhejiang Chinese Medical University | EARLY_Phase 1 |
| Not Yet Recruiting | Clinical Outcomes Of Mega-dosage Supplementations Of Cholecalciferol In Critically Ill Patients With Sepsis NCT06447441 | Chimei Medical Center | N/A |
| Recruiting | VExUS Combined With CVP to Predict Clinical Outcomes in Sepsis Participants NCT06524622 | The Second People's Hospital of Yibin | — |
| Withdrawn | Rezafungin Pharmacokinetics in Patients on ECMO NCT06329518 | Hartford Hospital | Phase 1 |
| Completed | Staphylococcus Haemolyticus in the Neonatal Intensive Care Unit of CHSD in 2023: Analysis and Trends NCT07013864 | Centre Hospitalier de Saint-Denis | — |
| Completed | Clinical Validation of BACTEC™ Plus Aerobic/F Culture Vials Compared With Equivalent Product NCT06426121 | Becton, Dickinson and Company | — |
| Recruiting | Efficacy and Safety of Methylene Blue in the Treatment of Severe Septic Shock NCT06481410 | First Affiliated Hospital of Zhejiang University | N/A |
| Not Yet Recruiting | Effect of Metabolic Dysfunction in Branched-chain Amino Acids on Cardiac Function in Patients With Sepsis NCT06258252 | West China Hospital | — |
| Completed | Precision Resuscitation With Crystalloids in Sepsis NCT06253585 | Emory University | N/A |
| Active Not Recruiting | Initial Feasibility Study of the CycloPE® Device NCT06970899 | PATH EX, Inc. | N/A |
| Completed | Pharmacokinetics and Pharmacodynamics of High Dose Ceftriaxone in Patients With Sepsis NCT07245966 | Prince of Songkla University | — |
| Unknown | Dexmedetomidine and Vasopressin in Septic Shock NCT06302998 | Mansoura University | Phase 2 |
| Completed | Influencing Factors of Vancomycin Trough Level in Critically Ill Children With Sepsis NCT06661772 | Benha University | — |
| Completed | Association of EASIX in Sepsis NCT06887439 | Sisli Hamidiye Etfal Training and Research Hospital | — |
| Recruiting | Integrated Clinical Decision Support for Empiric Antibiotic Selection in Sepsis NCT06103500 | Ottawa Hospital Research Institute | N/A |
| Recruiting | MID-STEP (MIDodrine for Sepsis Treatment and Early vasoPressor Weaning) Trial NCT06319248 | Mayo Clinic | Phase 2 |
| Completed | Evaluation of the Performance of a New Rapid Bacteremia Test in the Intensive Care Patient NCT06241248 | University Hospital, Bordeaux | — |
| Not Yet Recruiting | Multiple Study of Electroaccpuncture in ARDS NCT06278675 | Nanjing University of Traditional Chinese Medicine | N/A |
| Recruiting | miRNA in Septic Acute Kidney Injury NCT06498336 | University Hospital Ostrava | — |
| Not Yet Recruiting | Droplet Digital PCR Combines With Transcriptome Analysis in Early Warning of Sepsis in the Emergency Departmen NCT06028178 | Shanghai East Hospital | — |
| Recruiting | Mechanisms of Acute Kidney Injury in Severe Infections NCT06372444 | Uppsala University Hospital | — |
| Not Yet Recruiting | VEXUS and NGAL in the Diagnosis and Prognosis of Sepsis-associated Acute Kidney Injury NCT06305403 | Inonu University | — |
| Recruiting | Rapid Molecular Diagnosis of Sepsis in the Intensive Care Unit NCT06624618 | Maastricht University Medical Center | — |
| Unknown | Role of Active Deresuscitation After Resuscitation: NCT06326112 | Unity Health Toronto | Phase 2 |
| Completed | Comparison of Peripheral Perfusion Indicators and Lactate Levels NCT06727318 | Gulhane Training and Research Hospital | — |
| Recruiting | Early Severe Illness TrAnslational BioLogy InformaticS in Humans NCT05591924 | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | — |
| Not Yet Recruiting | Selective Antibiotics When Symptoms Develop Versus Universal Antibiotics for Preterm Neonates NCT06377397 | Indian Council of Medical Research | Phase 3 |
| Recruiting | Clinical Outcomes and Inflammatory Responses in Viral vs. Bacterial Sepsis NCT06491966 | Sichuan Provincial People's Hospital | — |
| Completed | EFFICACY OF PROLONGED INFUSION MEROPENEM IN CRITICALLY ILL PAEDIATRIC INTENSIVE CARE PATIENTS NCT07122596 | Pakistan Navy Station Shifa Hospital | Phase 4 |
| Completed | Impact of Prior SGLT2 Inhibitors Use on the Development and Progression of Sepsis-Associated Acute Kidney Inju NCT06902493 | University of Jazan | — |
| Not Yet Recruiting | Comparison of Nafamostat and Unfractionated Heparin in RRT for Sepsis Associated AKI NCT06375616 | Shen Lei | Phase 4 |
| Recruiting | Value of Laboratory Biomarkers in Prediction of Outcome in Septic Patients NCT06338124 | Egymedicalpedia | — |
| Completed | Effect of Lactiplantibacillus Plantarum DAD-13 on Inflammatory Markers in ICU Sepsis Patients NCT07072871 | PT Royal Medikalink Pharmalab | N/A |
| Recruiting | Metformin and Lactoferrin in Sepsis in Icu NCT06181422 | Tanta University | Phase 2 / Phase 3 |
| Completed | Assessment of Red Cell Distribution Width's Prognostic Ability in Septic Intensive Care Unit Patients NCT06847451 | Ain Shams University | — |
| Withdrawn | Reducing 30-Day Sepsis Readmissions: Impact of a Post Discharge Education Program NCT05602896 | Washington University School of Medicine | N/A |
| Unknown | Machine Learning Predictive Models for Sepsis Risk in ICU Patients With Intracerebral Hemorrhage NCT06326385 | Xiangya Hospital of Central South University | — |
| Completed | The Effect of Early Norepinephrine on Stroke Volume Index, Cardiac Index, Lactate, and Arterial Elastance in P NCT06461390 | Indonesia University | Phase 2 / Phase 3 |
| Completed | An Observational Study to Learn About the Occurrence of Disseminated Intravascular Coagulation Among Adults Wi NCT06373159 | Bayer | — |
| Recruiting | Evaluation of the Performance of the IDBIORIV Method in Pathogen Identification and Antibiotic Susceptibility NCT06219135 | Hospices Civils de Lyon | — |
| Recruiting | An Acupuncture Study for People At High Risk for Sepsis NCT06344819 | Memorial Sloan Kettering Cancer Center | Phase 2 |
| Recruiting | Stratifying Critically Ill Patients for Novel Ferroptosis or Pyroptosis Intervention Strategies NCT06928649 | University Hospital, Antwerp | N/A |
| Recruiting | Molecular Culture for the Diagnosis of Pediatric Sepsis NCT06018792 | Jip Groen | — |
| Unknown | Can Urinary Partial Oxygen Pressure be an Indicator of Acute Kidney Injury in Patients With Sepsis? NCT06124105 | Inonu University | N/A |
| Unknown | Adiposity and Immunometabolism in Sepsis NCT06307509 | NHS Greater Glasgow and Clyde | — |
| Completed | Pcrit and TPP for Risk Stratification in Patients With Sepsis NCT06657196 | Peking Union Medical College Hospital | — |
| Not Yet Recruiting | Outcomes of Children After Hospitalization in Intensive Care Unit NCT06124092 | St. Justine's Hospital | — |
| Not Yet Recruiting | Thyroid and Cortisol Hormone Response to Sepsis NCT06289179 | Assiut University | — |
| Recruiting | Physiologically Based Cord Clamping To Improve Neonatal Outcomes In Moderate And Late Preterm Newborns NCT06280872 | Queen Fabiola Children's University Hospital | N/A |
| Recruiting | Umbilical Mesenchymal Stromal Cells as Cellular Immunotherapy for Septic Shock NCT05969275 | Ottawa Hospital Research Institute | Phase 2 |
| Unknown | Role of PCO2 Gap as Predictor of Clinical Outcome in ICU Septic Patients NCT06256198 | Ain Shams University | — |
| Completed | Efficacy Of Zinc Towards The Outcome on Children With Sepsis NCT06556511 | dr. Aldora Jesslyn Oentari | N/A |
| Unknown | Use of Dobutamine in Patients With Sepsis and Maintained Hypoperfusion After Initial Volemic Resuscitation. NCT05953142 | Federal University of São Paulo | Phase 2 |
| Completed | AION BIOSYSTEMS, INC. Tempshield for Continuous Tempreature Monitoring NCT07145541 | AION Biosystems | N/A |
| Unknown | Population Pharmacokinetic Model of Amikacin and Vancomycin in Critically Ill Patients NCT06261164 | University Clinical Centre of Republic of Srpska | — |
| Recruiting | Efficacy of Anisodamine Hydrobromide Combined With Low-molecular-weight Heparin in the Treatment of Patients W NCT05634057 | Chen Ying | N/A |
| Unknown | Renin Angiotensin Aldosterone System In Septic Kids NCT06295393 | Northwell Health | — |
| Recruiting | Detection of Sepsis Occurrence by Using Blood Fluorescence NCT06689189 | Ningbo Medical Center Lihuili Hospital | — |
| Completed | Point of Care Evaluation of Fibrinolysis in Sepsis NCT06312488 | Policlinico Hospital | N/A |
| Recruiting | A Study of Enterorenal Syndrome Assessed by Gastrointestinal Ultrasound Combined with Renal Artery Resistance NCT06505512 | Zhangzhou Municipal Hospital | — |
| Completed | Adapting a Sepsis Transition and Recovery Program for Optimal Scale Up NCT05997420 | Wake Forest University Health Sciences | N/A |
| Unknown | Mecobalamin Combined With Ceftriaxone Sodium in the Treatment of Sepsis Liver Injury NCT06220929 | Sichuan Provincial People's Hospital | Phase 4 |
| Completed | Multicenter Symphony IL-6 Monitoring Sepsis ICU Study NCT06181604 | Bluejay Diagnostics, Inc. | — |
| Recruiting | Early Detection of At-risk Septic Patients NCT06253325 | University Hospital Southampton NHS Foundation Trust | — |
| Active Not Recruiting | Comparison Between Carbapenems and Noncarbapenem Beta-lactam Antibiotics in Septic Burn Patients NCT07096310 | Ain Shams University | Phase 1 / Phase 2 |
| Not Yet Recruiting | Registration of Sepsis Patients in the Emergency Department NCT06068192 | The First Hospital of Jilin University | — |
| Completed | Integrated Predictive Monitoring for Sepsis and Necrotizing Enterocolitis NCT07254559 | University of Virginia | — |
| Active Not Recruiting | Shock and Acute Conditions OutcOmes Platform NCT06376318 | Saint-Louis Hospital, Paris, France | — |
| Unknown | Risk Factors of Post-ERCP Sepsis NCT06187168 | Mansoura University | — |
| Unknown | ObsErvational Study of the Practical Cinical UTility of the NuQ.® H3.1 Nucleosome Levels in Adult Patients Wit NCT05922371 | Guy's and St Thomas' NHS Foundation Trust | — |
| Recruiting | ICU Combined Assessment of Cardio-Respiratory Exercise NCT06193980 | University of Manitoba | — |
| Completed | Therapeutic Drug Monitoring - Targeting IMproved Effectiveness NCT05971979 | Manchester University NHS Foundation Trust | — |
| Unknown | Continuous Renal Replacement Therapy With Oxiris in Acute Kidney Injury and Sepsis NCT06253377 | Nefro Consultoria de Doenças Renais Ltda | — |
| Active Not Recruiting | Safety Study of Inhaled Carbon Monoxide to Treat Pneumonia and Sepsis-Induced Acute Respiratory Distress Syndr NCT04870125 | Brigham and Women's Hospital | Phase 1 |
| Recruiting | Hemodynamic Response to Angiotensin-II When Used as the Second Vasopressor Agent for Septic Shock NCT06122987 | Kingman Regional Medical Center | Phase 4 |
| Unknown | Clinical Research on Shenfu Injection in Septic Patients NCT06157320 | Ruijin Hospital | N/A |
| Completed | Monocyte Distribution Width (MDW): An Early Marker of Sepsis in Patients With Comorbidities NCT06953154 | Hôpital Universitaire Sahloul | — |
| Completed | Prognostic Impact of Admission Glucose Level in Septic Patients Admitted to the Intensive Care Unit NCT04740333 | Meir Medical Center | — |
| Withdrawn | Personalised Real-time Interoperable Sepsis Monitoring (PRISM) NCT06238180 | Aisthesis Medical P.C. | — |
| Recruiting | Evaluation of a Multi-country Medical Oxygen Program NCT06087315 | Murdoch Childrens Research Institute | — |
| Active Not Recruiting | A Multicenter, Randomized, Double-blind, Placebo-controlled Phase II Dose Exploration Clinical Trial Evaluatin NCT06548854 | Grand Medical Pty Ltd. | Phase 2 |
| Completed | Sepsis Electronic Prompting for Timely Intervention and Care for Inpatients NCT06117618 | Columbia University | N/A |
| Completed | Sepsis Electronic Prompting for Timely Intervention and Care for Emergency Department Patients NCT06117605 | Columbia University | N/A |
| Recruiting | Beta-lactam Intermittent Versus Continuous Infusion and Combination Antibiotic Therapy in Sepsis NCT05681442 | Assistance Publique - Hôpitaux de Paris | Phase 4 |
| Completed | Strong Albumin Solutions in Patients With Septic Shock NCT05208242 | Manchester University NHS Foundation Trust | Phase 2 / Phase 3 |
| Enrolling By Invitation | Safety and Feasibility of Metformin for Sepsis Induced AKI NCT05900284 | Hernando Gomez | Phase 2 |
| Completed | Clinical Characteristics and Risk Factors for In-Hospital Mortality in Surgical Patients With Abdominal Sepsis NCT06756750 | Chinese PLA General Hospital | — |
| Completed | Comparison of the Efficacy of Paracetamol and Ibuprofen in the Management of Fever in Sepsis Patients NCT06061575 | Ankara City Hospital Bilkent | Phase 4 |
| Completed | Medical Device (MD) Derived Pharmacokinetic (PK) Parameters for Vancomycin (MD-PK) NCT05950984 | St George's, University of London | — |
| Unknown | Discharge Readmission Analysis and Management in Sepsis (DReAMS-2) NCT06099756 | Measure Labs, Inc. | — |
| Completed | Effects of Fluid Resuscitation on Capillary Refilling Time and Organ Functions in Septic Shock NCT06067516 | Samsun University | — |
| Unknown | Use of Presepsin in the Emergency Department NCT06150092 | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | — |
| Unknown | The Effect of rTEM in the Prognosis and Severity of Sepsis Induced ARDS NCT06063707 | Southeast University, China | — |
| Not Yet Recruiting | Nafamostat Mesilate in the Treatment of Severe Infection-associated Coagulopathy NCT06078839 | Xu Li | Phase 4 |
| Completed | BAR As a Mortality Predictor in Septic AKI NCT06584149 | Ain Shams University | — |
| Not Yet Recruiting | PUFAs in Preterm Infants NCT06045130 | The First Hospital of Jilin University | — |
| Active Not Recruiting | Assessing the Procalcitonin-guidance and Molecular-guided Diagnosis for Therapy of Severe Infections (the MODI NCT05909683 | Hellenic Institute for the Study of Sepsis | Phase 3 |
| Recruiting | HO-1/CREB3 Modulates Golgi Stress in Patients With Sepsis NCT06045780 | Tianjin Nankai Hospital | — |
| Recruiting | Molecular Subtype-Specific Mechanisms and Therapeutic Strategies in Sepsis NCT06287684 | Mater Dei Hospital, Malta | — |
| Unknown | Clinical Evaluation of the Effect of Metformin in Sepsis NCT05979038 | German University in Cairo | Phase 3 |
| Recruiting | Detection of Sepsis Occurrence by Using Blood Fluorescence NCT06745115 | Zhujiang Hospital | — |
| Completed | Correlation of Memory CD8+ T Cells With Sepsis Severity and Mortality: a Single-center, Unblinded, Prospective NCT05875740 | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | — |
| Not Yet Recruiting | 18-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in S. Aureus Bacteraemia NCT05361135 | University College, London | N/A |
| Unknown | DDX17 Orchestrate Septic Vascular Endothelial Pyroptosis by Controlling Gasdermin D Pore Formation NCT06013033 | Zhongda Hospital | — |
| Completed | Improvement of Organ Function by Apigenin in Elderly Patients With Sepsis NCT05999682 | Zhujiang Hospital | Phase 1 / Phase 2 |
| Recruiting | Senolytics To slOw Progression of Sepsis (STOP-Sepsis) Trial NCT05758246 | University of Minnesota | Phase 2 |
| Recruiting | Reducing Empiric VAncomycin Use in Pediatric Suspected Sepsis NCT05975671 | Children's Hospital of Philadelphia | N/A |
| Unknown | Electroacupuncture Modulates SPMs Metabolism and Respiratory Symptoms in Patients With Sepsis Complicating ARD NCT06006325 | Tianjin Nankai Hospital | N/A |
| Completed | Role of Early Point of Care Ultrasound in Management of Sepsis in Emergency Department NCT05849194 | Alexandria University | N/A |
| Completed | Non-Invasive Cardiac Output Monitor (NICOM) for Goal-directed Fluid Resuscitation for Inpatients With Hypotens NCT05630716 | University of Minnesota | N/A |
| Unknown | Thigh Muscle Mass and Muscle Wasting in Patients in the Emergency Department NCT05978154 | Korea University Ansan Hospital | — |