NCT06928649

Stratifying Critically Ill Patients for Novel Ferroptosis or Pyroptosis Intervention Strategies

Innovative Cell Death Diagnostics Allowing Stratifying Critically Ill Patients for Novel Ferroptosis or Pyroptosis Intervention Strategies

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 600 (estimated)
• Sponsor: University Hospital, Antwerp · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

In order to better determine which therapy is best for patiënts which present with organ falure during the course of their stay in the intesive care unit (ICU) , one has to determine which underlying mechanism is causing this organ falure. We will determine levels of so called "biomarkers" for ferroptosis (a mechan ism of iron-related cell death) in the peripheral blood and biological fluids of criticaly ill patients admitted to the ICU with a catastrrophy (severe infection, trauma ...) . Why ? If it turns out that this ferroptosis plays a role in the ocurrence of organ failure in the critially ill, this will lead to new therapies in the future as drugs become more and more available which can influene this biochemical "pahway". of iron-relatd death.

Conditions

• Sepsis
• Trauma Related Injuries
• Subarachnoid Haemorrhage (SAH)

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Blood sampling	Blood sampling: 3 first days of admision, 2 ml of plasma daily Urine, BALF, CSF sampling: 1 day during 3 first days of admission

Timeline

• Start date: 2024-03-13
• Primary completion: 2026-08-01
• Completion: 2026-08-01
• First posted: 2025-04-15
• Last updated: 2025-04-15

Locations

1 site across 1 country: Belgium