NCT07051694

Transcutaneous Auricular Vagus Nerve Stimulation as Adjuvant Treatment for Sepsis Patients

Exploratory Study on Transcutaneous Auricular Vagus Nerve Stimulation as Adjuvant Treatment for Sepsis Patients

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: Third Military Medical University · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The goals of this randomized clinical trial are to investigate the effects of transcutaneous auricular vagus nerve stimulation (taVNS) combined with standard intensive care on systemic organ function in septic patients, and exploring its potential mechanisms for improving overall outcomes in sepsis.The main question it aims to answer is whether taVNS can reduce the severity of sepsis patients by ameliorating systemic inflammation.Participants will receive standard intensive care treatment and be randomized to receive the taVNS or sham taVNS as adjuvant treatment twice a day for 7 consecutive days. Several evaluations will be done before and after the intervention.

Conditions

• Sepsis

Interventions

Type	Name	Description
DEVICE	taVNS	Transcutaneous Auricular Vagus Nerve Stimulation
DEVICE	sham-taVNS	sham transcutaneous auricular vagus nerve stimulation

Timeline

• Start date: 2025-02-27
• Primary completion: 2026-10-31
• Completion: 2026-12-31
• First posted: 2025-07-04
• Last updated: 2025-07-04

Locations

1 site across 1 country: China