NCT06372444

Mechanisms of Acute Kidney Injury in Severe Infections

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 15 (estimated)
• Sponsor: Uppsala University Hospital · Academic / Other
• Sex: All
• Age: 30 Years
• Healthy volunteers: Accepted

Summary

Renal perfusion and neutrophil-mediated inflammation will be assessed in the kidney in sepsis patients with acute kidney injury using positron emission tomography. For marked water will be used for renal perfusion and a newly developed PET tracer molecule (11C-GW457427) with specific binding to neutrophil elastase which provides a measure of the amount of infiltrating neutrophils in the renal parenchyma for inflammation. The study is performed in a PET-CT camera where anatomical imaging takes place at the same time as the PET examinations.

Detailed description

To study renal perfusion and neutrophil-mediated inflammation 10 critically ill patients with sepsis and acute kidney injury (AKI) and 5 healthy volunteers as controls will be recruited and examined at one time with marked water followed by neutrophil elastase tracer. At the same time, a CT scan is performed for anatomy. Plasma levels of inflammatory mediators will be measured. Clinical data will be collected. The endpoints are changes in renal perfusion and increased presence of neutrophil elastase in the renal parenchyma.

Conditions

• Sepsis
• AKI - Acute Kidney Injury
• Positron Emission Tomography (PET)

Interventions

Type	Name	Description
RADIATION	Positron emission tomography (PET)	Assessment of blood flow with marked water and assessment of neutrophil presence with neutrophil elastase tracer + CT

Timeline

• Start date: 2024-05-01
• Primary completion: 2026-04-03
• Completion: 2026-06-30
• First posted: 2024-04-18
• Last updated: 2024-12-06

Locations

1 site across 1 country: Sweden