NCT06193980

ICU Combined Assessment of Cardio-Respiratory Exercise

Exercise Testing in ICU Survivors to Evaluate ICU-acquired Weakness

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 50 (estimated)
• Sponsor: University of Manitoba · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study aims to investigate how sepsis and critical illness can impair the cardiovascular system and microcirculation in intensive care unit (ICU) patients, which can lead to long-lasting muscle weakness/dysfunction or ICU-Acquired Weakness (ICU-AW) and exercise limitations.

Detailed description

This longitudinal study will assess cardiovascular fitness and microvascular function through two (2) follow-ups after ICU discharge: at (i) 6 months, and (ii) 12 months. The goal is to understand how microvascular dysfunction contributes to ICU-AW and long-term exercise limitation in ICU survivors. Specific goals are: 1. Evaluate peak oxygen uptake and oxygen on/off kinetics in ICU survivors using a standardized cardiopulmonary exercise test (CPET) protocol. 2. Characterize skeletal muscle microvascular function in ICU survivors using high-resolution NIRS during CPET protocol. 3. Determine the association between impairments in skeletal muscle microvascular oxygen delivery and cardiovascular blood flow regulation in ICU survivors.

Conditions

• ICU Acquired Weakness
• Sepsis
• Shock
• Critical Illness
• Microcirculation

Timeline

• Start date: 2023-12-15
• Primary completion: 2028-07-01
• Completion: 2028-07-01
• First posted: 2024-01-08
• Last updated: 2025-11-28

Locations

1 site across 1 country: Canada