Critical Illness

1,148 registered clinical trials studyying Critical Illness — 199 currently recruiting.

Status	Trial	Sponsor	Phase
Not Yet Recruiting	Mode of Ventilation During Critical Illness at Multiple Centers NCT07313956	Vanderbilt University Medical Center	N/A
Not Yet Recruiting	General Surgery Patients at the Intensive Care Unit NCT06731296	Hospital Departamental de Villavicencio	—
Not Yet Recruiting	Surgical Critical Care Initiative (SC2i) Tissue and Data Acquisition Protocol (TDAP) in Burn Patients Improvin NCT07249762	Henry M. Jackson Foundation for the Advancement of Military Medicine	—
Not Yet Recruiting	TDAP in Burn Patients (Group 2) NCT07223684	Henry M. Jackson Foundation for the Advancement of Military Medicine	—
Not Yet Recruiting	Microbiome-guided Prophylaxis to Reduce Ventilator-Associated Pneumonia in Intensive Care Units: A Pilot Rando NCT07463339	University of Calgary	Phase 2
Not Yet Recruiting	Reduction of Muscle Catabolism Through Brain Activation in Burn Patients NCT07435402	Charles University, Czech Republic	N/A
Not Yet Recruiting	PRotEin Provision in Critical IllneSs -2 NCT07529522	Ziekenhuis Oost-Limburg	N/A
Not Yet Recruiting	Prognostic Value of Metabolic Characteristics in High-Risk Populations for Acute Kidney Injury After Cardiac S NCT07521787	Shanghai Zhongshan Hospital	—
Not Yet Recruiting	Exogenous Ketone Supplementation in ICU Delirium NCT07364162	Vanderbilt University Medical Center	Phase 1
Not Yet Recruiting	Lemborexant for Sleep and Delirium Prevention in Elderly ICU Patients NCT07407400	Mahidol University	Phase 4
Not Yet Recruiting	What is the Effect of Acute Kidney Injury on Weaning From Mechanical Ventilation in Critically Ill Adult Patie NCT07477652	Assiut University	—
Not Yet Recruiting	Individualized Analgesia in the Intensive Care Unit With a New Pain Assessment Bundle and Protocolized Analges NCT07473115	University of Zurich	—
Not Yet Recruiting	Critical Care Admission Following Emergency Department's Resuscitation Room Care NCT07411976	Centre Hospitalier Universitaire de Nīmes	—
Not Yet Recruiting	Optimizing Recovery in Trauma Patients by Integrating Enhanced Nutrition Delivery NCT06521086	Duke University	N/A
Not Yet Recruiting	Insights Into the Continuous Renal Replacement Therapy to Critical Ill Patients NCT07365111	University of Alberta	—
Not Yet Recruiting	MULTIMODAL APPROACH IN THE DIAGNOSIS OF SEPTIC AKI NCT07472452	Ankara Etlik City Hospital	—
Not Yet Recruiting	Association Between Dynamic Prealbumin Trajectories and Prognosis in Critically Ill Patients NCT07414160	The First Hospital of Jilin University	—
Not Yet Recruiting	Virtual Reality-Based Transitional Care for ICU Survivors NCT07482722	Mackay Memorial Hospital	N/A
Not Yet Recruiting	Implementation of Timely Management of Sepsis and Septic Shock Protocol in the Emergency Department and Intens NCT07460024	Al-Azhar University	N/A
Not Yet Recruiting	Mechanical Insufflation-Exsufflation in Critically Ill Patients NCT07420946	Medipol University	—
Not Yet Recruiting	Evaluating the Clinical Effectiveness of Sodium Bicarbonate for Critically Ill Patients With Metabolic Acidosi NCT07464431	Universität Münster	Phase 4
Recruiting	Exhaled Breath Condensate Analysis in Mechanically Ventilated Patients NCT06189924	The Institute of Molecular and Translational Medicine, Czech Republic	—
Recruiting	PK, Safety and Preliminary Efficacy Study of Montelukast in Critically Ill Infants With Developing Bronchopulm NCT07101640	Duke University	Phase 1 / Phase 2
Recruiting	iNO300 Therapy in Critically Ill Patients With Pneumonia NCT06950294	Massachusetts General Hospital	EARLY_Phase 1
Recruiting	Prognostic Value of Novel Biomarkers on Adverse Renal Outcomes in High-Risk Cardiac Surgery Patients NCT07418242	Guowei Tu	—
Not Yet Recruiting	Validation of the Turkish RDOS Using End-Tidal Carbon Dioxide NCT07383389	Istinye University	—
Not Yet Recruiting	Ultrasound-Based Prediction of Hemodynamic Instability During CVVHDF Initiation NCT07397663	Bursa Yuksek Ihtisas Training and Research Hospital	—
Not Yet Recruiting	Assessment of the Repeatability of Sublingual Microcirculation Function Measurements in Healthy Volunteers and NCT07397208	Medical University of Gdansk	—
Not Yet Recruiting	Undiluted and Diluted Nutrition NCT07352150	John Paul II Catholic University of Lublin	N/A
Recruiting	Clinical Application of Listening to Music to Prevent Delirium in the Intensive Care Unit NCT07369258	HOSPITAL BRITANICO DE BUENOS AIRES	N/A
Recruiting	Low Serum Creatinine as a Predictor of Prolonged Mechanical Ventilation and Weaning Failure NCT07177183	University Hospital Ostrava	N/A
Not Yet Recruiting	BIS in ICU Interventional Study NCT07350122	Medical University of Graz	N/A
Not Yet Recruiting	Life Sustaining Treatments in Critically Ill Children NCT07401420	Göteborg University	—
Active Not Recruiting	Metabolic Response to Supine Physiotherapy in Mechanically Ventilated ICU Patients NCT07361419	Universidad de Extremadura	—
Not Yet Recruiting	Enteral Versus Parenteral Nutrition During Recovery After Shock NCT07411014	Samsung Medical Center	N/A
Not Yet Recruiting	Pharmacokinetic Profiles of Subcutaneous Enoxaparin for Thromboprophylaxis in Critically Ill Patients With Ren NCT07384598	Clinique Saint Pierre Ottignies	N/A
Recruiting	Behavioral Health Collaborative Care Model in an ICU Recovery Clinic NCT07372586	Medical University of South Carolina	N/A
Completed	ICU Admission Diagnoses and ICU Mortality NCT07369206	Ataturk University	—
Recruiting	Predictive Value of Gastrointestinal Blood Flow for Enteral Nutrition Intolerance in Critically Ill Patients NCT07521111	Ruijin Hospital	—
Not Yet Recruiting	EIT-Guided Respiratory Physiotherapy for Prolonged Mechanical Ventilation (PMV) NCT07372794	Capital Medical University	N/A
Not Yet Recruiting	Validation of SOFA-2 for Mortality and Sepsis-3 Prevalence in Turkey NCT07300306	Marmara University	—
Not Yet Recruiting	Mechanisms of Prognostic Regulation andPrecision Phenotype Ldentification in Severe Infections Driven by Speci NCT07353970	Second Affiliated Hospital of Wenzhou Medical University	—
Completed	Non-apnea Saline-contrast EIT for Lung Perfusion Imaging in Spontaneously Breathing Patients NCT07489950	Ruijin Hospital	N/A
Not Yet Recruiting	Role of End-Tidal CO2 During Passive Leg Raising to Predict Fluid Responsiveness in ICU NCT07304648	Izmir Katip Celebi University	—
Not Yet Recruiting	Point-of-Care AI Assistance and Critical Care Outcomes: A Randomized Trial NCT07293078	MetroWest Artificial Intelligence Research Workgroup	Phase 1 / Phase 2
Not Yet Recruiting	Comparison of PPV and LVOT VTI During Passive Leg Raising to Predict Fluid Responsiveness NCT07304661	Izmir Katip Celebi University	—
Not Yet Recruiting	Trial on the Impact of Indirect Calorimetry-Guided Nutritional Support on Patient-Centered Outcomes in Critica NCT07343440	HEIDEGGER CP	N/A
Not Yet Recruiting	Accelerating Recovery After ICU Admission: Post-discharge Supplementation With Pasteurized Akkermansia Mucinip NCT07295353	Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)	N/A
Not Yet Recruiting	Critical Illness After Hematopoietic Cell Transplantation NCT07328724	Peking University People's Hospital	—
Not Yet Recruiting	MyokinE100 System: Closed Loop Electrical Muscle Stimulation to Mitigate ICU Acquired Weakness in Medical ICU NCT07362862	Health Discovery Labs	N/A
Recruiting	IMMUNOREA - Immunological and Inflammatory Determinants Associated With the Prognosis of Intensive Care Patien NCT07345169	Assistance Publique - Hôpitaux de Paris	—
Not Yet Recruiting	Real-Time Algorithm-Driven Ventilation Feedback to Improve Lung-Protective Ventilation in Critically Ill Patie NCT07307066	Peking Union Medical College Hospital	N/A
Not Yet Recruiting	Optimizing Enteral Nutrition Regimen for Critically Ill Patients NCT07270939	Hamad Medical Corporation	N/A
Not Yet Recruiting	Lactoferrin Use in ICU Patients NCT05936528	Mansoura University Hospital	Phase 4
Recruiting	IL-6 and Hemogram-Derived Inflammatory Indices for Mortality Prediction in Postoperative ICU Patients NCT07460141	Ezgi Günaydın	—
Recruiting	Dosage of Early Rehabilitation of ICU Patients NCT06960642	Medical University of Vienna	—
Not Yet Recruiting	Human Albumin for Resuscitation in Surgical Septic Shock: A Randomized Controlled Trial (ALBUS Study) NCT07212582	Mahidol University	Phase 3
Recruiting	Measuring Total Energy Expenditure in Critically Ill Patients Using the Doubly Labelled Water Method NCT07256340	Maastricht University Medical Center	N/A
Not Yet Recruiting	Remimazolam vs Midazolam to Reduce Delirium in Adults ≥65 Undergoing CPB Valve Surgery NCT07265128	Yonsei University	Phase 4
Not Yet Recruiting	Effect of Protein, Mobility Therapy and Electric Stimulation on Recovery in Older ICU Survivors NCT05326633	University of Maryland, Baltimore	EARLY_Phase 1
Recruiting	Incidence and Determinants of Joint Contractures in Mechanically Ventilated ICU Patients NCT07339397	Elazıg Fethi Sekin Sehir Hastanesi	—
Recruiting	Metabolic and Muscle Profile in ICU Survivors NCT07329530	Anne-Françoise Rousseau	N/A
Completed	Systemic Immune-Inflamation Index and Mortality in ICU Patients NCT07493759	Ataturk University	—
Recruiting	Effect of Protocolized Magnesium Replacement on Mortality and Atrial Fibrillation in Critically Ill Patients NCT07173855	Scarborough General Hospital	Phase 4
Recruiting	Comparison of the Efficacy and Safety of Ciprofol Versus Propofol for Sedation in ICU Patients Undergoing Non- NCT07536750	Nanfang Hospital, Southern Medical University	—
Recruiting	Innate Immune Response Monitoring Via Monocyte HLA-DR in Severe Intra-abdominal Infections at Risk of Fungal I NCT07130799	Central Hospital, Nancy, France	—
Recruiting	Wise Choices in the Intensive Care Unit NCT07013175	Karolinska Institutet	N/A
Not Yet Recruiting	Improving Survivorship for Critically Ill Patients Aged 65 and Over NCT07175961	Australian and New Zealand Intensive Care Research Centre	Phase 3
Recruiting	Timing of Renal Replacement Therapy in the Critically Ill Patients NCT03629977	Karolinska University Hospital	—
Recruiting	CReep and Maintenance flUid Sodium Chloride ADministration rEduction in cRitically Ill adultS NCT07189091	University Hospital, Antwerp	Phase 4
Recruiting	Safety and Feasibility of a Self-Balancing Exoskeleton for Rehabilitation in the Thoracic Surgical Intensive C NCT07220733	Wandercraft	Phase 1 / Phase 2
Recruiting	Effects of Negative Pressure Ventilation Onto Hemodynamics and Right Ventricular Funktion in Patients After Im NCT07034599	Karlsburg Hospital	N/A
Recruiting	The Effect of Continuous Versus Intermittent Enteral Nutrition on Metabolic Outcomes in Critically Ill Patient NCT07173504	Gelderse Vallei Hospital	N/A
Recruiting	Population Pharmacokinetics of Remifentanil in Low-Weight Critically Ill Patients NCT07301970	Fudan University	—
Recruiting	Improving Needs Among Older Adults NCT06588556	Duke University	N/A
Recruiting	The Effect of the Timing of Supplemental Parenteral Nutrition on the Prognosis of Critically Ill Patients (T-S NCT07085455	Dong Zhang	N/A
Recruiting	Neuromuscular Electrical Stimulation in a Patient on Invasive Mechanical Ventilation (MOVCARE) NCT07188350	Hospital Moinhos de Vento	N/A
Recruiting	The Effect of a 6-month Dietitian-tailored Nutrition Intervention to Patients With Critical Illness (DETAIL) NCT07149246	University Hospital of North Norway	N/A
Recruiting	Enhanced Protein Intake to Support Muscle Protein Synthesis in ICU NCT06714240	Maastricht University Medical Center	N/A
Not Yet Recruiting	RECOMMEND Platform Trial NCT06526533	Australian and New Zealand Intensive Care Research Centre	Phase 3
Recruiting	Using sEMG of the Diaphragm to Assess Readiness for Extubation NCT07110129	Cardiff and Vale University Health Board	—
Recruiting	COPM-Based Goal Setting Strategies in the PICU NCT07128446	Samsung Medical Center	N/A
Recruiting	VoiceLove: An App-Based COMMunication Tool Designed to Address DeliriUm and Improve Family ENgagement and PatI NCT06923462	Vanderbilt University Medical Center	N/A
Suspended	Post-Intensive Care Transitional Care, Rehabilitation, and Family-Support NCT06501365	University of Pittsburgh	N/A
Recruiting	MuScle WastIng and DysphaGia iN CriticAlly IlL Patients (SIGNAL) NCT07076524	Barts & The London NHS Trust	—
Not Yet Recruiting	Effect of Ventilation Mode in the Pupillary Light Reflex: A Crossover Study NCT07082569	Evangelismos Hospital	N/A
Recruiting	Surface Electrical Myography, Oxygen Consumption, Effort, and Weaning in the Mechanically Ventilated Patient i NCT07109570	Leiden University Medical Center	—
Not Yet Recruiting	Endogenous Energy Production in Critically Ill Patients NCT07059988	Karolinska University Hospital	N/A
Not Yet Recruiting	Early Multimodal Therapy and Mechanical Ventilation NCT06133504	Fundación Santa Fe de Bogota	N/A
Not Yet Recruiting	Intermittent Versus Continuous Glucose Monitoring in Intensive Care Unit NCT07088549	University Medical Centre Ljubljana	N/A
Completed	Circadian Rhythm in Critical Illness NCT07063303	Atılım University	N/A
Not Yet Recruiting	Mitochondrial Assessment in Critical Ill Patients in Intensive Care NCT07018843	University Hospital Southampton NHS Foundation Trust	—
Recruiting	The Intensive Care Platform Trial NCT06667999	Anders Perner	Phase 4
Recruiting	Real-time NOMA Evaluation NCT06996626	David T Huang	N/A
Not Yet Recruiting	The VIP3 (Very Old Intensive Care Patients) Study: Family Involvement in Treatment Decisions for Old ICU Patie NCT07035951	St George's, University of London	—
Recruiting	Feasibility and Efficacy of Ambulance-Based m-Health for Pediatric Emergencies (FEAMER) Trial NCT07027813	Weill Medical College of Cornell University	N/A
Recruiting	Combining Chest X-Ray and Arterial Blood Gas Findings to Predict Need for Mechanical Ventilation in Critically NCT07001696	Zagazig University	—
Recruiting	Correlation Study Between SMA Blood Flow Reactivity and Acute Gastrointestinal Injury in Critically Ill Patien NCT07001943	Peking Union Medical College Hospital	—
Active Not Recruiting	Comfort Care Bundle NCT07366021	Akdeniz University	N/A
Enrolling By Invitation	Investigation of the Relationship Between Nutritional Status Assessment and Frailty in Critical Care Patients NCT07143084	Ankara Training and Research Hospital	—
Enrolling By Invitation	Prevalence of Sarcopenia in Patients Admitted to ICU and Its Progression During Hospitalization. NCT07303335	Hospital Mutua de Terrassa	—
Recruiting	Therapeutic Drug Monitoring of Beta-lactams and Renal Hyperclearance in Patients Admitted to Intensive Care fo NCT06999161	Centre Hospitalier Universitaire de Nīmes	—
Enrolling By Invitation	Assessing the Relationship Between Frailty and Skeletal Muscle Thickness in Critically Ill Patients NCT07310667	Ankara Training and Research Hospital	—
Recruiting	Relationship Between Pulse Pressure and Stroke Volume in the Critically Ill Patients: The ANDROMEDA-PEGASUS St NCT06737614	Pontificia Universidad Catolica de Chile	—
Recruiting	Preoperative Fasting vs. Not Fasting in Critically Ill Patients NCT06751043	Massachusetts General Hospital	N/A
Recruiting	Effect of Dynamic Arterial Elastance and Assisted Fluid Management Software Guided Resuscitation in Septic Sho NCT06937918	Mahidol University	N/A
Recruiting	Evaluation of Fentanyl Transdermal Patch Absorption in Hemodynamically Unstable ICU Patients. NCT06966869	Tel-Aviv Sourasky Medical Center	—
Recruiting	Use of Vasopressin in Patients at High Risk of Acute Kidney Injury Admitted to the ICU NCT06547892	Hospital do Coracao	Phase 2
Not Yet Recruiting	Live Music for Critically Ill Children NCT06845787	University Medical Center Groningen	N/A
Recruiting	Episodes of (Dis)Connected Consciousness in ICU Survivors NCT07048951	University of Liege	—
Completed	Curriculum for Airway Skills in Critically Ill Adults: a Delphi Evaluation NCT06689748	University of Texas Southwestern Medical Center	—
Recruiting	12-hour Time Limited Feeding in Critical Care NCT06741761	University of Kansas Medical Center	N/A
Recruiting	Non-Invasive Blood Pressure Monitoring in ICU Patients Using the DARE Device NCT07052123	Centre Hospitalier de Saint-Denis	N/A
Completed	Use of Lactate-to-Albumin, CRP-to-Albumin, and Procalcitonin-to-Albumin Ratios to Predict Mortality in ICU Pat NCT07242027	Medical University of Silesia	—
Recruiting	Predictive Model for Mortality in Older People With Critical Illness NCT06727903	Consorci Sanitari de l'Alt Penedès i Garraf	—
Recruiting	Effectiveness of Ventilation Modes in Intensive Care: A Comparison of Mandatory Minute Ventilation and Synchro NCT06961227	Harran University	—
Not Yet Recruiting	SOFA Score with Serum Procalcitonin Versus SOFA Score with Neutrophil/lymphocyte Ratio in Predicting Sepsis an NCT06847477	Ain Shams University	—
Not Yet Recruiting	Hyperinflammation and Hyperferritinemia in Critically Ill Patients NCT06820905	Charles University, Czech Republic	—
Recruiting	Comparing High-protein Vs. Standard Protein Nutritional Support in Critically Ill Patients At Risk for Refeedi NCT06825377	Shahid Beheshti University	N/A
Recruiting	The "What Is Important to Us" Communication Intervention Pilot Clinical Trial NCT06208332	Seattle Children's Hospital	Phase 2
Recruiting	Physical Therapist Inter-Rater Reliability in Neuro-Muscle Ultrasound in Critically Ill Patients NCT07032870	University of Chile	—
Recruiting	The Effects of Endotracheal Suctioning on Pain and Serum Markers NCT06692400	Loma Linda University	N/A
Recruiting	The Role of Brain-Bone Marrow-Gut Interaction Following Major Trauma NCT06606119	University of Florida	—
Recruiting	Sedation Efficacy and Safety of Remazolam Besylate in Ventilated Surgical Critically Ill Patients NCT06575530	Beijing Shijitan Hospital, Capital Medical University	Phase 4
Active Not Recruiting	Intubation Checklist in the Intensive Care Unit NCT06791317	Karolinska University Hospital	—
Not Yet Recruiting	Feasibility and Preliminary Effects of a Spiritual Care Strategy on Psychological Disorders in Critically Ill NCT06048783	Pontificia Universidad Catolica de Chile	N/A
Recruiting	UP STUDY - Decipher Persistent Critical Illness Through in Deep Clinical Phenotyping. NCT07510776	Lisbon Academic Medical Center - Centro Académico de Medicina de Lisboa	—
Recruiting	Assessing Fluid-responsiveness Using Non-invasive Hybrid Diffuse Optics on Peripheral Muscle NCT07298720	Corporacion Parc Tauli	—
Not Yet Recruiting	Diluted and Undiluted Enteral Nutrition NCT06516835	Medical University of Lublin	N/A
Not Yet Recruiting	Using a Population Pharmacokinetic Model to Estimate the Dosage of Teicoplanin in Patients With Hematologic Ma NCT06674330	National Taiwan University Hospital	—
Completed	Fluid Challenge in Intensive Care The FENICE II Study NCT06394947	Humanitas Clinical and Research Center	—
Recruiting	Calibration of Esophageal Balloon Catheter in Spontaneous and Mandatory Mechanical Ventilation NCT06584604	Leiden University Medical Center	—
Recruiting	The Gut Microbiome - Source of Sepsis and Novel Target in Intensive Care Units? NCT06749483	Jena University Hospital	—
Recruiting	A Multi-Modal Combination Intervention to Promote Cognitive Function in Older Intensive Care Unit Survivors NCT06411561	University of Washington	N/A
Recruiting	Ultrasound Detection of Body Composition in Critical Care NCT06728722	Ain Shams University	—
Recruiting	PICU-related Sleep and Circadian Dysregulation Pilot Study NCT06505447	State University of New York at Buffalo	N/A
Recruiting	Precision Sedation in Intensive Care NCT06991777	Oslo University Hospital	N/A
Not Yet Recruiting	Definition of Acute Kidney Injury by Urine Output in Critically Ill Patients NCT06722924	Uppsala University	—
Recruiting	Exhaled Breath: A Novel Technique for Rapid Diagnosis of Respiratory Diseases and Infections NCT06775106	Oregon Health and Science University	—
Completed	Using Continuous Passive Motion to Prevent Ankle Problems in ICU Patients NCT06944431	Shin Kong Wu Ho-Su Memorial Hospital	N/A
Recruiting	Physiological Effects and Safety of Continuous High-frequency Oscillatory Ventilation in ICU Patients NCT06702813	Shanghai Zhongshan Hospital	N/A
Completed	Double Triggering Asynchrony in Mechanically Ventilated Patients. NCT07380607	Mansoura University	—
Enrolling By Invitation	Data Analysis and Physical Function Evaluation Index Development for Early Diagnosis and Monitoring of ICU-acq NCT06669494	Samsung Medical Center	—
Recruiting	Geriatric Assessment at Discharge From the Intensive Care Unit in Patients Aged 75 Years and Older: a Feasibil NCT06513130	University Hospital, Strasbourg, France	N/A
Recruiting	Scores in Critically Ill Patients After Craniotomy NCT06762184	Beijing Tiantan Hospital	—
Recruiting	Muscle and Subcutaneous Tissue Variation by Ultrasound and Impedance Linked to Fluid Balance in ICU Patients NCT06697470	Dr F Duprez	—
Recruiting	Assessment of Stroke Volume in Shock Using Echocardiography Versus Bioreactive Impedance NCT07020637	University of Nevada, Las Vegas	—
Not Yet Recruiting	Nutritional Status of Critically Ill Diabetic Patients NCT06564168	Assiut University	—
Recruiting	Light and Noise: Objectively Assessing Environmental Risk Factors for Delirium in the ICU NCT06294158	Medical University of Graz	—
Recruiting	Achieving nuTritional Target in criticAlly Ill patieNts With iMpairEd gastroiNtesTinal Dysfunction NCT06510348	Romanian Society for Enteral and Parenteral Nutrition	N/A
Completed	Is Combined Respiratory Muscle Training, Incorporating Inspiratory and Expiratory Training, Feasible in Adult NCT07055789	Royal College of Surgeons, Ireland	N/A
Recruiting	Treatment Strategy of Human Gamma Globulin on the Therapy for Intensively Ill Children With Inflammatory Storm NCT04850456	Children's Hospital of Fudan University	—
Active Not Recruiting	Rehabilitation Gaming System for Intensive Care Units NCT06267911	University of the Balearic Islands	N/A
Completed	Ventilator Settings for Bronchoscopy During Mechanical Ventilation: a Randomized Controlled Study NCT06562725	Centre Hospitalier Arras	N/A
Completed	Effects of Prolonged and Chronic Critical Illness Induced by Brain Injury on Metabolic State NCT06545825	Federal Research and Clinical Centre of Intensive Care Medicine and Rehabilitology	—
Terminated	Impact of Interactive ICU Diary on Psychological Distress NCT06512987	Taipei Medical University	N/A
Active Not Recruiting	Ventilator Settings and Outcomes in Pediatric Patients on ECMO for Severe Respiratory Failure NCT06899009	University Medical Center Groningen	—
Recruiting	Nutrition Practice in Critically Ill Adults NCT06576895	Australian and New Zealand Intensive Care Research Centre	—
Enrolling By Invitation	Communication With Mechanically Ventilated Intensive Care Patients NCT06977555	Oslo University Hospital	N/A
Recruiting	End-Tidal Oxygen for Intubation in the Emergency Department NCT06578468	Sydney Local Health District	N/A
Completed	Developing and Testing a Nurse-Led Technology-Enhanced Family Engagement Program NCT06128655	Rutgers, The State University of New Jersey	N/A
Recruiting	Preventing Cardiovascular Collapse With Vasopressors During Tracheal Intubation NCT05014581	University of Turin, Italy	Phase 3
Unknown	Discomfort in Intensive Care Patients - IPREA-N NCT06091046	Oslo University Hospital	—
Not Yet Recruiting	Echocardiographic Evaluation of RV Injury in the ICU NCT05525936	Assistance Publique - Hôpitaux de Paris	—
Recruiting	Impact of Echocardiography on Management of Critically Ill Neonates NCT06533787	Sahar Abozkaly Mahmoud	—
Enrolling By Invitation	Impact of the Introduction of a Performance Improvement Program on the Initial Management of Sepsis and Septic NCT06657625	University Hospital, Brest	—
Recruiting	Asia Pediatric Intensive Care Epidemiology and Outcomes Study NCT06481644	KK Women's and Children's Hospital	—
Recruiting	Embedded Palliative Care in the MICU NCT06574672	Washington University School of Medicine	N/A
Recruiting	Ultrasound Airway Assessment of Critically Ill Preeclamptic; Comparison Between Two Technique NCT06651879	Ain Shams University	N/A
Completed	Construction and Application of the Visualization Training Platform Based on a Multimodal Standardized Dataset NCT06431802	Children's Hospital of Fudan University	N/A
Not Yet Recruiting	Predicting Adverse Kidney Events of Cardiac Surgery-Associated Acute Kidney Injury Using Novel Biomarkers NCT06351813	Shanghai Zhongshan Hospital	—
Recruiting	Behavioral Economic & Staffing Strategies in the ICU NCT06184945	University of Nebraska	N/A
Active Not Recruiting	Intensive Care Unit Rehabilitation Protocols NCT07179718	Hacettepe University	N/A
Recruiting	Feasibility Study on Implementing Consultation-based High-quality Palliative Care Services in Intensive Care U NCT06490835	Seoul National University Hospital	N/A
Recruiting	Developing Strategies to Facilitate Consent of Legally Authorized Representatives to Clinical Trials NCT06471400	University Hospital Freiburg	N/A
Recruiting	Medical Honey for Wound Treatment in Intensive Care. (MICARéa) Randomized, Controlled, Single-center Pilot Stu NCT06150326	University Hospital, Angers	N/A
Completed	Hypomagnesemia and Its Clinical Outcome NCT07089004	Bangladesh Bioscience Research Group	—
Recruiting	Pilot Feasibility Study of a Pragmatic Mixed-Methods Randomized Controlled Trial on a Follow-Up Bundle of Care NCT06681649	Queen's University	N/A
Recruiting	Ethnic and Gender Based Admittance Patterns in the ICU NCT05513456	Karolinska Institutet	—
Recruiting	Improving Psychological Outcomes for Acute Respiratory Failure Survivors Using a Self-Management Intervention NCT06341972	Johns Hopkins University	N/A
Recruiting	Epidemiology and Treatment Strategy of Open Respiratory Phenotype in Critically Ill Patients NCT06393179	Southeast University, China	N/A
Recruiting	CONTINUation of Enteral Nutrition Prior to Extubation Compared to Standard Care NCT06382727	Emma Ridley	N/A
Suspended	Pediatric Prehospital Airway Resuscitation Trial NCT06364280	Ohio State University	N/A
Enrolling By Invitation	Enhancing Parent/Caregiver Engagement in the Pediatric Intensive Care Unit (PICU): A PICU Journal NCT06117345	Vanderbilt University Medical Center	N/A
Recruiting	Reestablishing Sleep and Circadian Alignment in Medical Intensive Care Unit (MICU) Patients Via a Mechanistic NCT05551325	Yale University	N/A
Completed	Physiotherapy and Optimised Nutrition in Survivors of Critical Illness NCT06159868	University Hospitals Coventry and Warwickshire NHS Trust	N/A
Unknown	Role of Active Deresuscitation After Resuscitation: NCT06326112	Unity Health Toronto	Phase 2
Not Yet Recruiting	User Experience of a Telemedicine Platform for the Follow-up of Post Intensive Care Syndrome (PICS) NCT06438380	Corporacion Parc Tauli	—
Recruiting	Identifying Diabetes and Impaired Glucose Tolerance in ICU Patients NCT07261865	University Medical Center Groningen	—
Not Yet Recruiting	PK/PD Study of Anti-Infective Drugs in Critically Ill Patients Receiving Extracorporeal Membrane Oxygenation T NCT06319677	The Third Xiangya Hospital of Central South University	—
Active Not Recruiting	Association Between Resuscitation Orders and Mortality in ICU Patients NCT06373068	Karolinska Institutet	—
Active Not Recruiting	Strategy to Avoid Excessive Oxygen Using an Autonomous Oxygen Titration Intervention NCT06374225	University of Colorado, Denver	N/A
Recruiting	Early Severe Illness TrAnslational BioLogy InformaticS in Humans NCT05591924	London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's	—
Completed	Value of Early Postoperative Peptide-based Formula in Critically Ill Obstetrics on Recovery Enhancement NCT06164301	Ain Shams University	N/A
Completed	Effectiveness of Familiar Voices and Nature Sounds Among Critically Ill Comatose Patients NCT06470802	Vo Thi Hong Nhan	N/A
Recruiting	Azithromycin for Critical Asthma - Pediatrics NCT06223828	Johns Hopkins All Children's Hospital	Phase 2 / Phase 3
Recruiting	Epidemiological Features of Emergent Highly Resistant Bacteria in Tunisian Intensive Care Units NCT06392568	Abderrahmane Mami Hospital	—
Completed	Early Delirium Prediction Via Serial EEG Trajectories and Machine Learning NCT07536854	Ajou University School of Medicine	—
Recruiting	Renal Resistive Index as a Predictor of Acute Renal Impairment in High-risk Patients NCT06386796	Aswan University	—
Completed	Metabolic Pathway Analysis in Intensive Care Unit Patients With Refeeding Syndrome NCT06344546	Karolinska University Hospital	—
Completed	Effect of Lactiplantibacillus Plantarum DAD-13 on Inflammatory Markers in ICU Sepsis Patients NCT07072871	PT Royal Medikalink Pharmalab	N/A
Active Not Recruiting	Attitudes to Decisions to Withdraw or Withhold Life-sustaining Treatments in Critically Ill Children NCT06281743	Göteborg University	—
Recruiting	PRactice of VENTilation in Critically Ill PEDiatric Patients NCT06220825	University Medical Center Groningen	—
Completed	Anticipating Decline and Providing Therapy NCT06182995	Wake Forest University Health Sciences	N/A
Unknown	Prevalence and Affecting Factors of Sleep and Circadian Rhythm Disorders in ICU NCT06346613	Shanghai Zhongshan Hospital	—
Active Not Recruiting	A Model for Drug Concentration Prediction of Vancomycin NCT06431412	Peking Union Medical College Hospital	—
Unknown	MOdifiable facTors to Improve VentilAtion ThErapy in ICU NCT06288724	Nat Intensive Care Surveillance - MORU	—
Withdrawn	Incidence and Associated Risk Factors of ARC in the Trauma Critically Ill Older Than 50 Years Old NCT04766944	McGill University Health Centre/Research Institute of the McGill University Health Centre	—
Completed	Near-Infrared Light Devices Versus Landmark Approach for Peripheral Venous Access in Intensive Care Unit NCT06234293	Centre Hospitalier Régional d'Orléans	N/A
Recruiting	The INVADE Study: INnominate Vein Approach for Central Catheterization in Difficult to cannulatE Patients NCT04265703	Hospital Civil de Guadalajara	N/A
Recruiting	A Study of Healthy Microbiome, Healthy Mind NCT06020703	Mayo Clinic	N/A
Completed	Eyecontrol coMmunication Platform for dEliRium manaGemEnt in Intensive Care Units (EMERGE) NCT06029244	Beth Israel Deaconess Medical Center	N/A
Completed	Probiotics for Preventing ICU-Acquired Infections in Critically Ill Patients: A Pilot Study NCT07144124	Imam Abdulrahman Bin Faisal University	N/A
Recruiting	Continuous vs Bolus Protein (Protein Regimen Outcomes) in Critically Ill Children (Kids In Distress) NCT06721923	University of British Columbia	N/A
Completed	pEEG Monitoring Effect on Delirium, Ventilator Days, and PICS NCT06019078	Fraser Health	—
Recruiting	ICU Fluid Utilization Survey in Southeast Asia NCT06034990	Chulalongkorn University	—
Recruiting	Evaluating the Unmet Needs of Older Adults to Promote Functional Recovery After a Critical Illness NCT06006000	Yale University	—
Completed	Intrarenal Venous Flow Change During Fluid Removal in Critically Ill Patients: A Prospective Exploratory Study NCT06216119	Mahidol University	—
Recruiting	Early Vitamin D3 Supplementation for Critically Ill Patients NCT05937789	National Taiwan University Hospital	N/A
Completed	Point of Care Evaluation of Fibrinolysis in Sepsis NCT06312488	Policlinico Hospital	N/A
Completed	Homocysteine in Critically Ill Preeclampsia NCT06413576	Ain Shams University	—
Recruiting	Pharmacological Reversal of Neuromuscular Blockade in Critically Ill Patients NCT05993390	Seoul National University Hospital	N/A
Withdrawn	Bedside Air Quality in ICU and Clinical Outcome NCT06201754	First Affiliated Hospital of Zhejiang University	—
Unknown	Palliative Care Protocol for Adult Patients Hospitalized in Critical Care Units. NCT06483958	University of Chile	N/A
Recruiting	Hemodynamic Variations During Remote Ischemic Conditioning in Critical Ill Patients NCT06536231	Lithuanian University of Health Sciences	N/A
Recruiting	Intra-Hospital Transport of Critically Ill Patients in Intensive Care Unit NCT06455696	French Society for Intensive Care	—
Completed	Vasopressin Use in Septic Shock From Türkiye NCT06953297	Karadeniz Technical University	—
Completed	Physiological Dead Space and Intensive Care Mortality in Mechanically Ventilated Patients NCT06963944	Karadeniz Technical University	—
Recruiting	Oxygen Consumption (VO2), Effort, and Weaning in the Mechanically Ventilated Patient in the Intensive Care Uni NCT06391424	Leiden University Medical Center	—
Unknown	The Effects of Different Gastric Residual Volume Thresholds for Holding Feeding in Internal Medicine. NCT06113393	National Taiwan University Hospital	N/A
Active Not Recruiting	Predicting Mortality in Patients With Return of Spontaneous Circulation After Cardiac Arrest NCT07020091	Ahmet Düzgün	—
Unknown	Assessment of Admission to the ICU of Onco-hematological Patients. NCT06113601	University Hospital A Coruña	—
Completed	Early Enteral Feeding and Clinical Outcomes in ICU Patients NCT07131098	Loai Muawiah Zabin	N/A
Recruiting	HYPER MIND - Hyperoxia Effects on Cerebral Hemodynamics NCT07377162	Erasme University Hospital	N/A
Completed	The DINE-Normal Proof-of-concept Study NCT06115044	North Bristol NHS Trust	N/A
Recruiting	The Efficacy of P0.1-guided Sedation Protocol in Critically Ill Patients Receiving Invasive Mechanical Ventila NCT06203405	Siriraj Hospital	N/A
Unknown	Detection of Pathogen and Antibiotic Resistance Genes by Targeted Next-Generation Sequencing in ICU Patients. NCT06157372	Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University	—
Completed	Fiberoptic Bronchoscopy in Severe Ventilator-associated Pneumonia NCT07149909	Benha University	N/A
Recruiting	ICU Combined Assessment of Cardio-Respiratory Exercise NCT06193980	University of Manitoba	—
Completed	Leucine-enriched Branched-chain Amino Acid on Muscle Thickness, Interleukin-6, SOFA Score in Critical Illness NCT06167772	Indonesia University	N/A
Unknown	The INSIGHT Feasibility Study Ultrasound in the Intensive Care Unit: A Randomised Controlled Feasibility Trial NCT05569798	King's College Hospital NHS Trust	N/A
Completed	Insulin Degludec vs Insulin Glargine for Glycemic Control in Critical Illness Hyperglycemia NCT06178874	Ain Shams University	N/A
Recruiting	Electroencephalography and Sleep Quality With Lormetazepam in the Intensive Care Unit NCT06473415	Charite University, Berlin, Germany	—
Completed	Practice of Fluid Therapy in Critically Ill Invasively Ventilated Patients NCT05968066	Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)	—
Active Not Recruiting	Family Integration in Therapy Activities in the Intensive Care Unit: The FIT-ICU Feasibility Study NCT06071793	St. Joseph's Healthcare Hamilton	N/A
Active Not Recruiting	Optimal Timing of Computerized Cognitive Training for Older Intensive Care Unit Survivors NCT05467410	University of Washington	N/A
Recruiting	Albumin To Enhance Recovery After Acute Kidney Injury NCT04705896	Ottawa Hospital Research Institute	Phase 4
Completed	Messy Memories: Mobile Application Therapy Following Critical Illness NCT05849454	Columbia University	N/A
Completed	Medical Device (MD) Derived Pharmacokinetic (PK) Parameters for Vancomycin (MD-PK) NCT05950984	St George's, University of London	—
Completed	Indicator Amino Acid Oxidation in ICU Patients NCT06104527	Maastricht University Medical Center	N/A
Completed	Measuring the Recovery of Barts Health Patients With Electronic Follow-up NCT06038045	Queen Mary University of London	—
Completed	Musical Intervention and Physiological Stress and Inflammatory Biomarkers in Mechanically Ventilated ICU Patie NCT06120660	University of Oviedo	N/A
Recruiting	The Family Perspectives Project Pilot Trial NCT06039501	Matthew Modes	N/A
Recruiting	Incidence of Episodes of (Dis)Connected Consciousness Among Emergency Patients Admitted in the Resuscitation R NCT06362525	University of Liege	—
Unknown	The Effect of Sequential Feeding for Circadian Rhythm and Gut Flora Rhythm in Critically Ill Patients NCT06083831	Qingdao University	—
Recruiting	Intensive Care Decision-making, Survival and Dying Well NCT06027684	University of Manchester	—
Recruiting	Indirect Calorimetry Guided Energy Provision in Critically Ill Patients With Obesity NCT06053216	Australian and New Zealand Intensive Care Research Centre	N/A
Recruiting	Standard Dose Continuous Renal Replacement Therapy (CRRT) Versus Low-Dose CRRT ( KETZEREI ) NCT06021288	Universität Münster	N/A
Recruiting	High-flow Nasal Oxygenation for Apnoeic Oxygenation During Intubation of the Critically Ill NCT05883137	Region Stockholm	—
Recruiting	Post Intensive Care Unit Atrial Fibrillation NCT05860894	Centre Hospitalier Universitaire de Besancon	N/A
Active Not Recruiting	Driving Rehabilitation and Innovation for Evaluating Risk in Post-Intensive Care Unit Survivors NCT05999903	Baylor Research Institute	—
Unknown	Plasma Sodium and Sodium Administration in the ICU NCT06037928	University Hospital, Linkoeping	—
Unknown	Evaluation of Pain Levels by Quantitative Pupillometry During the Placement of Deep Venous Catheters in Sedate NCT05962996	Centre Hospitalier Régional Universitaire de Tours	—
Recruiting	Bedside Renal Ultrasound Assessment in Patients With Acute Kidney Injury NCT06156098	Qin Zhang	—
Completed	The African Critical Illness Outcomes Study NCT06051526	University of Cape Town	—
Unknown	Immune Dysfunction in Critical Illness: Utility of a Panel of Genes and Molecules Involved in the Immunologica NCT05954260	David Pérez Torres	—
Recruiting	Magnesium Prophylaxis for the Prevention of New-Onset Atrial Fibrillation in Critically Ill Patients NCT05829317	Dr. Stephanie Sibley	Phase 4
Completed	Efficacy of Intravenous N-Acetylcysteine in Preventing Linezolid-Induced Thrombocytopenia in Critically Ill Pa NCT05944458	Helwan University	Phase 4
Unknown	Development of an AI-based Emergency Imaging Multi-Disease Rapid Joint Screening System NCT05974163	Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University	—
Recruiting	Effects of Early Testosterone Gel Administration on Physical Performance in the Critically Ill NCT05825092	University Hospital, Clermont-Ferrand	Phase 2
Recruiting	Individualised Blood Pressure Targets Versus Standard Care Among Critically Ill Patients With Shock NCT05850962	Rakshit Panwar	N/A
Completed	Blood-Interstitial Fluid Glucose Gap NCT07240103	Chinese Medical Association	—
Completed	Development of a Novel Algorithm for Real-Time Bedside Assessment of Insulin Resistance in Critically Ill Pati NCT07385391	Chinese Medical Association	—
Completed	The Blood-Interstitial Glucose Gap NCT07251764	Chinese Medical Association	—
Recruiting	Incidence and Factors Associated to the Development of PICS-F Among ICU Relatives: A Longitudinal Exploratory NCT05827354	Pontificia Universidad Catolica de Chile	—
Completed	Effect of Enteral Formula (Commercial vs. Homemade) on Muscle Mass in Trauma Brain Injury NCT06949163	Hospital General "Dr. Miguel Silva" de Morelia	N/A
Recruiting	NIBP Validation Study NCT05673408	Philips Clinical & Medical Affairs Global	—
Active Not Recruiting	Development of the Italian Version of the ICU Mobility Scale (IMS). Cross-cultural Adaptation, Italian Transla NCT07195942	Istituto Clinico Humanitas	—
Completed	Effect of Continuous Versus Cyclic Daytime Enteral Nutrition on Circadian Rhythms in Critical Illness NCT05795881	Leiden University Medical Center	N/A
Unknown	A Study to Evaluate the Introduction of New Staffing Models in Intensive Care: a Realist Evaluation (SEISMIC-R NCT05917574	University of Hertfordshire	—
Unknown	Correlation Between Muscle Strength and Thickness in Critically Ill Patients NCT06289244	Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico	—
Unknown	Efficacy and Safety of Fospropofol Disodium Versus Propofol for Deep Sedation in Critically Ill Patients NCT05870514	Xiaobo Yang, MD	Phase 2
Completed	Parental Feelings About Their Child Needing a Central Line NCT05842356	Columbia University	N/A
Completed	Degludec Insulin Use in Critically Ill Patients NCT06056167	King Faisal Specialist Hospital & Research Center	N/A
Unknown	Influence of Vasopressors on Anti-Xa Activity in Critically Ill Patients NCT06055907	Medical University of Gdansk	—
Completed	Correlation Between Acute Gastrointestinal Injury and Venous Return in Critical Ill Patients NCT06667297	Peking Union Medical College Hospital	—
Unknown	Effect of Inhaled Nitric Oxide on Pulmonary Ventilation/Perfusion Ratio Assessed by EIT in Patients With ARDS NCT05873647	Union Hospital, Tongji Medical College, Huazhong University of Science and Technology	—
Recruiting	Optimised Nutritional Therapy and Early Physiotherapy in Long Term ICU Patients (NutriPhyT Trial) NCT05865314	HEIDEGGER CP	N/A
Unknown	Acute Kidney Injury in Intensive Care Patients NCT05970952	Haseki Training and Research Hospital	—
Completed	Pilot Study on Device-assisted Mobilisation of Critically Ill Patients NCT05716451	Charite University, Berlin, Germany	N/A
Unknown	Skeletal Muscle Wasting in ICU Patients NCT06234826	Frank Vandenabeele	—
Active Not Recruiting	Proactive Prescription-based Fluid Management vs Usual Care in Critically Ill Patients on Kidney Replacement T NCT05473143	Centre hospitalier de l'Université de Montréal (CHUM)	N/A
Completed	Expert Consensus Statements for the Management of a Physiologically Difficult Airway Using the Delphi Method ( NCT05762068	University of Texas Southwestern Medical Center	—
Completed	Continuous Glucose Monitoring for Hyperglycemia in Critically Ill Patients NCT05442853	Malcom Randall VA Medical Center	N/A
Unknown	Bedside Ultrasound Assessment of Feeding Tube Position in the Intensive Care Unit NCT06077617	Hospital de Clinicas de Porto Alegre	—
Recruiting	Music Listening: A Mechanistic Trial NCT05541029	University of Pittsburgh	N/A
Suspended	Assessment of Kidney Function and Osteomuscular Status After Critical Care NCT04980092	University of Liege	—
Recruiting	REmotely Monitored, Mobile Health Supported Multidomain Rehabilitation Program With High Intensity Interval Tr NCT05218083	Duke University	N/A
Withdrawn	Dexmedetomidine Cycling and Sleep in the Pediatric ICU NCT05003102	Vanderbilt University Medical Center	Phase 4
Unknown	Eye Movement Desensitisation and Reprocessing (EMDR) to Improve Mental Health Following Intensive Care Admissi NCT05591625	University Hospital Southampton NHS Foundation Trust	N/A

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