NCT07411014

Enteral Versus Parenteral Nutrition During Recovery After Shock

Enteral Versus Parenteral Nutrition During Early Recovery in the Critically Ill After Shock: A Prospective, Multicenter, Open-label, Randomized Controlled Study

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 1,150 (estimated)
• Sponsor: Samsung Medical Center · Academic / Other
• Sex: All
• Age: 19 Years
• Healthy volunteers: Not accepted

Summary

This study compares enteral nutrition and parenteral nutrition in critically ill adult patients recovering from shock while receiving decreasing doses of vasopressors in the intensive care unit. Eligible patients will be randomly assigned to receive either enteral or parenteral nutrition during the early recovery phase of shock. The study aims to determine whether enteral nutrition improves clinical outcomes, including ICU mortality and ICU-acquired infections, compared with parenteral nutrition.

Detailed description

Critically ill patients with shock are at high risk of nutritional deficits, yet the optimal route of nutrition during the recovery phase of shock remains uncertain. Although enteral nutrition is generally preferred in critical care, it is often delayed in patients receiving vasopressors due to concerns about gastrointestinal intolerance and ischemia. Recent evidence suggests that patients with decreasing vasopressor requirements may tolerate enteral nutrition safely. This multicenter, randomized, open-label trial enrolls adult ICU patients recovering from shock with decreasing vasopressor support. Participants are randomized to receive either enteral nutrition or parenteral nutrition during the early recovery phase. The study evaluates a composite outcome of ICU mortality and ICU-acquired infections, along with other clinically relevant secondary outcomes.

Conditions

• Shock
• Critical Illness
• Nutritional Support
• Vasopressor Therapy

Interventions

Type	Name	Description
OTHER	enteral nutrition	Patients will be randomized in a 1:1 ratio to receive either enteral nutrition or parenteral nutrition. Participants assigned to this group will receive enteral nutrition during the early recovery phase of shock while receiving decreasing vasopressor support in the intensive care unit.
OTHER	Parenteral Nutrition	Patients will be randomized in a 1:1 ratio to receive either enteral nutrition or parenteral nutrition. Participants assigned to this group will receive parenteral nutrition during the early recovery phase of shock while receiving decreasing vasopressor support in the intensive care unit.

Timeline

• Start date: 2026-02-01
• Primary completion: 2029-08-01
• Completion: 2029-12-31
• First posted: 2026-02-13
• Last updated: 2026-02-18

Locations

1 site across 1 country: South Korea