NCT04980092

Assessment of Kidney Function and Osteomuscular Status After Critical Care

Assessment of Kidney Function and Osteomuscular Status in Survivors of a Prolonged Stay in Intensive Care Unit

• Status: Suspended
• Phase: —
• Study type: Observational
• Enrollment: 100 (estimated)
• Sponsor: University of Liege · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This observational study aims to assess kidney function through direct glomerular filtration rate (GFR) using iohexol clearance, compared to estimated GFR based on creatinine and cystatin C equations. Kidney function will also be evaluated through renal fibrosis biomarkers. Kidney function will be correlated to body composition, muscle turnover biomarkers, and bone micro-architecture.

Detailed description

The investigators developed a post-ICU clinic where complications of the post-intensive care syndrome are detected. Muscle function is assessed by clinical testings, muscle strength measurement. Body composition is measured by electrical bioimpedance. Bone mass is assessed using dual-energy radiographic absorptiometry. It is well known that ICU survivors experience a loss of muscle mass. This can lead to misinterpretation of estimated GFR based on creatinine equations. The aim of the present study is to assess the evolution of kidney function after a prolonged stay in ICU, using GFR equations based on cystatin C, and to compare it to measured GFR using iohexol clearance. The second aim is to explore the evolution of bone and muscle health in these patients.

Conditions

• Critical Illness
• Kidney Injury
• Muscle Loss
• Bone Loss

Interventions

Type	Name	Description
OTHER	one-year follow-up	patients will be followed during the year after ICU discharge, in order to assess kidney function, and muscle and bone health

Timeline

• Start date: 2023-03-01
• Primary completion: 2026-03-01
• Completion: 2027-01-01
• First posted: 2021-07-28
• Last updated: 2025-12-31

Locations

1 site across 1 country: Belgium