| Not Yet Recruiting | Choice-Based Support for Adults Starting or Restarting Antiretroviral Therapy in Cape Town, South Africa HIV Care Loss to Followup | N/A | 2026-02-01 |
| Recruiting | '5 Rs to Rescue' A Cluster Trial With an Embedded Process Evaluation Surgery, Failure to Rescue | — | 2024-09-01 |
| Not Yet Recruiting | Evaluation of a 2-session Parent Training Programme for Caregivers of Younger Children in Zimbabwe Child Maltreatment | N/A | 2024-06-07 |
| Completed | The African Critical Illness Outcomes Study Critical Illness, Mortality | — | 2023-09-01 |
| Recruiting | B. Infantis Supplementation to Improve Immunity in Infants Exposed to HIV Hiv, Vaccine Reaction, Microbial Colonization | N/A | 2023-08-11 |
| Not Yet Recruiting | Test to Treat TB: Impact of Sputum Sequencing-guided Individualised Therapy on Outcomes in Drug-resistant Tube Tuberculosis, Multidrug-Resistant | N/A | 2023-07-01 |
| Completed | Comparing a Novel Point-of-care Cytokine Biomarker Lateral Flow Test With Nucleic Acid Amplification Tests for STI | — | 2023-06-01 |
| Completed | South African Paediatric Surgical Outcomes Study 2 Paediatric Surgery, Anaemia, Iron Deficiency Anemia | Phase 4 | 2023-02-09 |
| Recruiting | B.R.A.I.N in People Living With HIV Study HIV-associated Neurocognitive Disorders | N/A | 2023-01-16 |
| Unknown | Point-of-care Ultrasound Abnormalities in Early Onset Preeclampsia Preeclampsia, Pulmonary Edema, Cardiac Function | N/A | 2022-11-28 |
| Recruiting | Point-of-care Ultrasound Abnormalities in Eclampsia Eclampsia | N/A | 2022-11-21 |
| Recruiting | Gene Expression Profiles in Spinal Tuberculosis. Tuberculosis, Spinal, Tuberculosis, Osteoarticular, Tuberculosis | — | 2022-10-25 |
| Unknown | Evaluating Acid Reflux After Oesophageal Stenting Using Anti-reflux Stents Esophageal Cancer, Reflux, Gastroesophageal | N/A | 2022-10-01 |
| Completed | Childhood Adversity, Inflammatory Reactivity and Persistent Pain Chronic Pain, Central Sensitisation, Immune Response | — | 2022-06-21 |
| Completed | Cardiovascular Outcomes and Mortality in Vascular Surgical Patients Perioperative Complication, Cardiovascular Complication | — | 2022-05-17 |
| Active Not Recruiting | Evaluating the Impact of Computer-assisted X-ray Diagnosis and Other Triage Tools to Optimise Xpert Orientated Tuberculosis, COVID-19, HIV Infections | N/A | 2022-02-23 |
| Completed | Iron Deficiency Anaemia in Pregnant Patients Presenting for Antenatal Care Iron Deficiency Anemia of Pregnancy | — | 2022-01-31 |
| Recruiting | Remote Ischaemic Conditioning in STEMI Patients in AFRICA STEMI, Remote Ischaemic Conditioning, Myocardial Reperfusion Injury | N/A | 2022-01-12 |
| Recruiting | High vs. Standard Dose Rifampicin for Effusive Tuberculous Pericarditis Tuberculous Pericarditis, HIV Status | Phase 2 | 2022-01-10 |
| Recruiting | Vaginal Microbiome Research Consortium for Africa Healthy | — | 2021-10-15 |
| Active Not Recruiting | Testing New Strategies for Patients Hospitalised With HIV-associated Disseminated Tuberculosis Disseminated Tuberculosis, HIV | Phase 3 | 2021-08-11 |
| Active Not Recruiting | Xpert Active Case-finding Trial 3 (XACT-3) Tuberculosis | N/A | 2021-03-26 |
| Recruiting | Same Day Diagnosis of Extrapulmonary TB (TB Serositis and TB Meningitis). Tuberculosis, Extrapulmonary | N/A | 2021-03-16 |
| Completed | An Observational Study of Distress, Immune Function, and Pain in HIV. Chronic Pain, HIV, Distress, Emotional | — | 2021-02-11 |
| Completed | Health System Dynamic & Resource Requirement in a South African COVID-19 Field Hospital Field Hospitals, COVID-19 Pandemic, Health Systems | — | 2021-02-11 |
| Completed | the PrEsentation, Rationale and Impact of reperFUSION for Acute Coronary Syndromes in Cape Town and the Garden Acute Coronary Syndrome, ST Elevated Myocardial Infarction, Non ST Elevation Myocardial Infarction | — | 2021-02-01 |
| Terminated | Catalysing the Containment of COVID-19 COVID-19 | Phase 2 / Phase 3 | 2020-08-27 |
| Recruiting | Atorvastatin to Reduce Inflammation After Tuberculosis Treatment Completion Tuberculosis, Pulmonary | Phase 2 / Phase 3 | 2020-07-14 |
| Withdrawn | Chloroquine Outpatient Treatment Evaluation for HIV-Covid-19 Covid-19, HIV | Phase 3 | 2020-05-01 |
| Unknown | African Covid-19 Critical Care Outcomes Study Severe Acute Respiratory Syndrome Coronavirus 2 | — | 2020-05-01 |
| Unknown | Telemedicine for First Trimester Abortion in South Africa Abortion in First Trimester | N/A | 2020-02-27 |
| Unknown | Pharmacometrics to Advance Novel Regimens for Drug-resistant Tuberculosis-PandrTB Tuberculosis Multi-drug Resistant Tuberculosis | — | 2020-01-30 |
| Completed | Standard Versus Double Dose Dolutegravir in Patients With HIV-associated Tuberculosis HIV Infections, Tuberculosis | Phase 2 | 2019-12-19 |
| Completed | BNP Evaluation Before Surgery Study: an Observational Study of Natriuretic Peptide Levels Prior to Surgery. Surgery, Cardiovascular | — | 2019-10-14 |
| Completed | Peer Support to Mitigate the Impact of Stigma in Young HIV+ Pregnant & Postpartum Women Hiv | N/A | 2019-08-30 |
| Completed | Tenofovir-lamivudine-dolutegravir Combination as Second-line ART: a Randomised Controlled Trial HIV Infections | Phase 2 | 2019-08-08 |
| Completed | Linezolid, Aspirin and Enhanced Dose Rifampicin in HIV-TBM Tuberculosis Meningitis, HIV-1-infection | Phase 2 | 2019-06-12 |
| Completed | African Surgical OutcomeS-2 (ASOS-2) Trial Surgery, Morality | N/A | 2019-05-06 |
| Unknown | The ASOS-2 Trial Maternal Mortality Sub-study Maternal Mortality, Cesarean Section, Africa | — | 2019-05-06 |
| Unknown | MethOxyflUraNe at moderaTe High AltItudes for PAIN Management Pain | Phase 4 | 2019-05-01 |
| Unknown | Enhanced Recovery After Trauma Surgery Penetrating Abdominal Trauma | N/A | 2019-03-29 |
| Completed | A Snapshot Study of Patients Affected by Gunshot Related Injuries in Trauma in South Africa Trauma, Multiple, Gun Shot Wound | — | 2019-02-18 |
| Completed | Hypertension And Surgery Study: Evaluating the Implementation of a Hypertension Guideline Protocol Hypertension, Metabolic Syndrome, Non-Compliance, Medication | N/A | 2019-01-14 |
| Unknown | Self-expandable Metal Stents Versus Multiple Plastic Stents for Palliation of Biliary Obstruction Bile Duct Obstruction, Extrahepatic, Cancer of the Pancreas, Cancer of the Bile Duct | N/A | 2019-01-01 |
| Unknown | Endotracheal Dilator to Improve Oxygenation Tracheal Stenosis, Airway Disease, Pediatric Respiratory Diseases | N/A | 2018-09-01 |
| Completed | Immediate Versus Delayed IUD Insertion After Second Trimester Medical Abortion Contraception | N/A | 2018-05-10 |
| Completed | Study of Hip and Knee Arthroplasty in South Africa Osteoarthritis, Knee, Osteoarthritis, Hip, Arthritis, Rheumatoid | — | 2018-05-07 |
| Completed | COMparison of Portable Fingertip Versus Conventional Pulse OximeteRs Trial Anesthesia, Hypoxemia | — | 2018-04-15 |
| Terminated | Clinical Evaluation of Adjusted Doses of Darunavir/Ritonavir With Rifampicin in HIV-infected Volunteers HIV Infections | Phase 1 | 2018-04-12 |
| Completed | Single-dose Novel Selective alpha2c Antagonist Pharmaco-MRI Study in Healthy Volunteers Healthy Volunteer | Phase 1 | 2018-03-26 |
| Completed | Prevalence of Hyperglycemia and Anaemia in Elective Surgical Patients Anemia, Iron Deficiency, Hyperglycemia | — | 2017-10-16 |
| Completed | Timing of Referral to Adherence Clubs for Antiretroviral Therapy Hiv | N/A | 2017-01-18 |
| Suspended | Left Cardiac Sympathetic Denervation for Cardiomyopathy Feasibility Pilot Study Dilated Cardiomyopathy, Ischemic Cardiomyopathy, Non-ischemic Cardiomyopathy | Phase 2 | 2016-11-24 |
| Completed | Xpert Active Case-finding Trial 2: Community-based Active Case-finding for Tuberculosis in South Africa Tuberculosis | N/A | 2016-11-01 |
| Completed | The Bioavailability of Rifampicin in (FDCs) Widely Used in South Africa to Treat Drug-susceptible (TB) Tuberculosis | Phase 1 | 2016-11-01 |
| Completed | Prevalence of Hypertensive Disease in Patients Presenting for Elective Surgery in the Western Cape, South Afri Hypertensive Episode | — | 2016-10-24 |
| Completed | Modified Endotracheal Balloon Dilator to Improve Patient Oxygenation and Allow Ventilation During Airway Proce Tracheal Stenosis | N/A | 2016-10-01 |
| Unknown | The Correlate of Risk Targeted Intervention Study Tuberculosis | Phase 2 / Phase 3 | 2016-09-20 |
| Completed | Acid-Base and Point of Care Ultrasound in Severe Preeclampsia Pre-Eclampsia | — | 2016-03-01 |
| Unknown | IMPI 2 - A Trial of Intrapericardial Alteplase in Large Pericardial Effusion Pericardial Effusion | Phase 3 | 2016-02-01 |
| Completed | The Impact of Obesity on Cardiac Function in Pregnancy Pregnancy, Obesity | — | 2016-01-01 |
| Completed | Postpartum Adherence Clubs for Antiretroviral Therapy Hiv | N/A | 2016-01-01 |
| Completed | An Open-label RCT to Evaluate a New Treatment Regimen for Patients With Multi-drug Resistant Tuberculosis Tuberculosis, Multidrug Resistant Tuberculosis, Extensively-drug Resistant Tuberculosis | Phase 2 / Phase 3 | 2015-11-12 |
| Completed | Pharmacometric Optimization of Second Line Drugs for MDR Tuberculosis Treatment Multidrug-resistant Tuberculosis | — | 2015-07-30 |
| Completed | Collaborative Care for the Detection and Management of Depression Among Adults Receiving Antiretroviral Therap HIV/AIDS, Depression, Chronic Diseases of Lifestyle | N/A | 2015-04-01 |
| Unknown | iLink (Incentives for Linkage to ART) Study: A Mixed-methods Study to Improve Linkage to HIV Care HIV | N/A | 2015-04-01 |
| Completed | Task Sharing for the Care of Severe Mental Disorders in a Low-income Country Schizophrenia, Bipolar Disorder, Major Depressive Disorder | Phase 3 | 2015-03-01 |
| Completed | Childhood Convulsive Status Epilepticus Management In A Resource Limited Setting Pediatric Status Epilepticus | Phase 3 | 2015-03-01 |
| Withdrawn | Impact of Medical Follow-up Discharge Package Follow-up Study, Medical In-patients | N/A | 2015-03-01 |
| Completed | The Hope Soap Study: a Hand-washing Intervention Among Children in South Africa Hand-washing Behavior, Diarrhea | N/A | 2014-09-01 |
| Completed | Use of Low Sensitivity Pregnancy Test for Self-assessment of Medical Abortion Completion of Medical Abortion | N/A | 2014-08-01 |
| Unknown | Sub-project: Use of Small Implantable ECG Recorder in Pregnant Women With Arrhythmia Arrhythmias in Pregnancy | — | 2014-06-01 |
| Completed | A Trial Of Intravenous N-Acetylcysteine In The Management Of Antituberculous Drug-Induced Hepatitis Drug-Induced Liver Injury | Phase 2 / Phase 3 | 2014-05-01 |
| Completed | The Role of Melatonin in the Effective Attainment of Sleep Electroencephalograms (EEG) in Children Epilepsy, Electroencephalogram, Children | Phase 3 | 2014-04-01 |
| Completed | Evaluation of the Parent Centre's Positive Parenting Skills Training. Parenting Behaviour, Child Behaviour Problems | N/A | 2014-04-01 |
| Completed | The Sinovuyo Caring Families Project: a Randomized Controlled Trial of a Parenting Programme Child Behaviour Problems | N/A | 2014-02-01 |
| Completed | VATS ( Video-Assisted Thoracoscopy) Compared to Reinsertion of a Thoracostomy Tube for Persistent Haemothorax Haemothorax, Empyema | N/A | 2014-01-01 |
| Completed | The Utility of Intensified Case Finding Combined With a Package of Novel TB Diagnostics Using a Mobile Clinic Tuberculosis | N/A | 2013-10-01 |
| Completed | Task Sharing Counseling Intervention by Community Health Workers for Prenatal Depression in South Africa Moderate Depression, Clinical Depression, Postpartum Depression | N/A | 2013-10-01 |
| Completed | 4-question "RACY" Delirium Screening Tool Validation Study Delirium | N/A | 2013-09-01 |
| Unknown | Pregnancy-Related Obesity Prevention Through Education & Communication Technology in AFRICA:The PROTECT-AFRICA Obesity | N/A | 2013-09-01 |
| Completed | Preventing TB-IRIS in High-risk Patients: a Randomized Placebo-controlled Trial of Prednisone Immune Reconstitution Inflammatory Syndrome, HIV, Tuberculosis | Phase 3 | 2013-08-30 |
| Completed | Strategies to Optimize Antiretroviral Therapy Services for Maternal & Child Health: the MCH-ART Study HIV | N/A | 2013-03-01 |
| Completed | Sinovuyo Caring Families Project - Pilot Trial Child Behavior, Parenting, Child Abuse | Phase 1 | 2013-02-01 |
| Unknown | Bi Treatment With Hydralazine/Nitrates Versus Placebo in Africans Admitted With Acute Heart Failure Acute Heart Failure, Left Ventricular Dysfunction | Phase 3 | 2013-01-01 |
| Completed | A Trial of the Urine LAM Strip Test for TB Diagnosis Amongst Hospitalized HIV-infected Patients Tuberculosis | N/A | 2013-01-01 |
| Completed | Optimal Dosing of 1st Line Antituberculosis and Antiretroviral Drugs in Children (a Pharmacokinetic Study) Tuberculosis, HIV | Phase 4 | 2012-11-01 |
| Completed | The Pan African Pulmonary Hypertension Cohort Study Pulmonary Hypertension | — | 2012-06-01 |
| Completed | Trial of Point-of-treatment Xpert MTB/RIF Assay Tuberculosis | N/A | 2010-10-01 |
| Completed | Gene Xpert Diagnosis of TB Using Tracheal Aspirates From Intensive Care Unit (ICU) Patients Tuberculosis | N/A | 2010-08-01 |
| Completed | Study Comparing the Effectiveness of Incentives on Physical Activity Behavior in a Health Insured Population Physical Activity Behavior, Wellness Programs | N/A | 2010-07-01 |
| Completed | Antibiotic Efficacy in Pneumonitis Following Paraffin (Kerosene) Ingestion in Children Kerosene Pneumonitis | N/A | 2010-07-01 |
| Completed | Early Versus Delayed BCG Vaccination of HIV-exposed Infants HIV Exposure, HIV Infection | Phase 2 | 2010-06-01 |
| Completed | Typing of Human Papilloma Virus (HPV) From Female Genital Warts Genital Warts, Human Papilloma Virus | — | 2010-04-01 |
| Withdrawn | Etoricoxib in Acute Ankle Ligament Sprains Sprain | Phase 4 | 2009-11-01 |
| Unknown | Working on Wellness (WOW) Intervention Physical Activity | N/A | 2009-11-01 |
| Completed | Laparoscopy Versus Clinical Follow up to Detect Diaphragm Injury Diaphragm Injury | N/A | 2009-09-01 |
| Completed | Utility of Sputum Induction and Novel Technologies to Improve TB Diagnosis in a High HIV Prevalence Primary Ca Tuberculosis | N/A | 2009-08-01 |
| Completed | Pharmacokinetic Interaction Between the Antimalarial Combination Artemether/Lumefantrine and Combination Antir HIV Infections, Malaria | Phase 4 | 2009-06-01 |
| Completed | A Trial of Adjunctive Prednisolone and Mycobacterium w Immunotherapy in Tuberculous Pericarditis Tuberculous Pericarditis | Phase 3 | 2008-12-01 |
| Completed | Artemether/Lumefantrine and Nevirapine Interaction Study in HIV-infected Adults Malaria, HIV | Phase 4 | 2008-10-01 |
| Unknown | Rapid Diagnosis of Pulmonary Tuberculosis Tuberculosis | N/A | 2008-02-01 |
| Completed | Impact of Employee Wellness Programme Obesity | N/A | 2008-01-01 |
| Completed | Randomised Trial of Two Educational Intervention for Improving Evidence-based Practice Knowledge, Atttitudes a Health Knowledge, Attitudes, Practice | N/A | 2007-11-01 |
| Completed | Isoniazid Plus Antiretroviral Therapy to Prevent Tuberculosis in HIV-infected Persons Tuberculosis, Latent Tuberculosis Infection, HIV Infections | N/A | 2007-11-01 |
| Unknown | Randomised Trial Comparing Metal and Plastic Biliary Stents Stents for Palliating Malignant Jaundice Biliary Obstruction | Phase 4 | 2007-06-01 |
| Completed | A Randomised Efficacy Study of Combination Antimalarials to Treat Uncomplicated Malaria Malaria | N/A | 2004-01-01 |
| Unknown | Effect of Public Sector Antiretroviral Treatment Programme on Tuberculosis and Immunization Care Tuberculosis | N/A | 2003-05-01 |
| Completed | Isoniazid Prophylaxis With Concomitant Cotrimoxazole in HIV-infected Children Tuberculosis | Phase 3 | 2003-01-01 |
| Completed | A Randomised Efficacy Study of Combination Antimalarials to Treat Uncomplicated Malaria Malaria | N/A | 2003-01-01 |
| Completed | Intravenous Immunoglobulins as Effective Treatment in Sydenham's Chorea Sydenham Chorea, Post Streptococcal Movement Disorder | N/A | 2002-05-01 |
| Completed | Combination Antimalarials in Uncomplicated Malaria Malaria | N/A | 2002-01-01 |
| Completed | Surgical Management of Blood in the Pericardial Sac After Penetrating Trauma Heart Injuries | N/A | 2001-10-01 |
| Unknown | Randomized Controlled Trial of Percutaneous and Intradermal BCG Vaccination. Tuberculosis | Phase 4 | 2001-03-01 |