NCT00954785

Etoricoxib in Acute Ankle Ligament Sprains

The Efficacy and Safety of Administration of the COX-2 Selective NSAID, Etoricoxib (120mg od. for 7 Days) Compared to Diclofenac (50 mg Tds. for 7 Days) and Placebo as Adjunct Treatment in the First 7 Days of Treatment of Acute Grade II Lateral Ankle Ligaments Sprains: A Clinical Trial

• Status: Withdrawn
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 0 (actual)
• Sponsor: University of Cape Town · Academic / Other
• Sex: All
• Age: 18 Years – 45 Years
• Healthy volunteers: Accepted

Summary

The aim of the study is to measure the effectiveness of treatment over 7 days with commonly used anti-inflammatory medications namely etoricoxib and diclofenac (Voltaren) on reducing the severity of pain, swelling and loss of function (range of movement, proprioception) arising from a mild to moderate sprain (partial tear) of the lateral (outer) ligaments of the ankle joint. This injury is commonly known as an ankle sprain.

Conditions

• Sprain

Interventions

Type	Name	Description
DEVICE	Ankle brace	Sports Stirrup ankle brace (Aircast)
DRUG	Diclofenac 50 mg tds	In the diclofenac group, each subject will receive 50 mg diclofenac in the morning, at mid-day and in the evening
DRUG	Etoricoxib 120 mg mane	In the etoricoxib group, each subject will receive 120 mg etoricoxib in the morning, and placebo medication in the evening and at mid-day

Timeline

• Start date: 2009-11-01
• Primary completion: 2010-12-01
• Completion: 2011-07-01
• First posted: 2009-08-07
• Last updated: 2013-06-20

Locations

2 sites across 1 country: South Africa