NCT00869700

Pharmacokinetic Interaction Between the Antimalarial Combination Artemether/Lumefantrine and Combination Antiretroviral Therapy Including Lopinavir/Ritonavir in HIV-infected Adults

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 18 (actual)
• Sponsor: University of Cape Town · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Despite the clinical significance of potential interactions between antimalarials and antiretrovirals, no drug interaction studies have been published and there is an urgent need to address this gap in current knowledge. The aim of the study is to investigate the pharmacokinetics (PK) of antimalarial combination artemether/lumefantrine (AL) and combination antiretroviral therapy (cART) including lopinavir/ritonavir (LPV/r) in HIV-infected adults.

Conditions

• HIV Infections
• Malaria

Interventions

Type	Name	Description
DRUG	Artemether/Lumefantrine	80mg artemether/480mg lumefantrine Trade name: Coartem Indication: for management of non-severe malaria

Timeline

• Start date: 2009-06-01
• Primary completion: 2010-02-01
• Completion: 2010-02-01
• First posted: 2009-03-26
• Last updated: 2010-06-28

Locations

1 site across 1 country: South Africa