NCT06393179

Epidemiology and Treatment Strategy of Open Respiratory Phenotype in Critically Ill Patients

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: Southeast University, China · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Monitoring airway pressure is essential for patients with mechanical ventilation. However, static airway pressure does not reflect alveolar pressure at all. Airway pressure is supposed to completely interrupt the communication between proximal airway opening and the distal alveolar and/or small airway structures. In this condition, some alveoli may still be inflated but do not communicate with proximal airways and auto-PEEP will give a biased estimated of mean alveolar pressure. To be note, distinguishing the airway closure and alveolar collapse can be challenging at times. The quasi-static PV curve is a useful bedside tool to set mechanical ventilation, which may help us to identify the airway closure and alveolar collapse. Meanwhile, the quasi-static PV curve can only reflects a global behaviour of the lung, while EIT may be a useful tool to assess the regional information on airway closure and alveolar collapse.

Conditions

• Mechanical Ventilation Pressure High
• Critical Illness

Interventions

Type	Name	Description
OTHER	pressure-volume curve with a low-flow insufflation of 5 L/min	The patient undergoes a pressure-volume curve with a low-flow insufflation of 5 L/min while in a state of analgesia, sedation, and absence of spontaneous breathing.

Timeline

• Start date: 2024-05-30
• Primary completion: 2024-08-30
• Completion: 2024-08-30
• First posted: 2024-05-01
• Last updated: 2024-08-16

Locations

1 site across 1 country: China