NCT07034599

Effects of Negative Pressure Ventilation Onto Hemodynamics and Right Ventricular Funktion in Patients After Implantation of a Left Ventricular Assist Device.

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: Karlsburg Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

All patients undergoing an implantation of a durable left ventricular assist device and monitored by pulmonary artery catheter showing no adverse events after surgery are included in the study and ventilated for 15 minutes using extra thoracic negative pressure ventilation and usual intrathoracic positive pressure ventilation. Hemodynamics changes between both ventilation modes, especially focussing on right ventricular function and measured by a pulmonary artery catheter, are compared.

Conditions

• Critical Illness
• Heart Failure
• LVAD

Interventions

Type	Name	Description
DEVICE	Negative pressure ventilation	All participants are ventilated with negative pressure ventilation first
DEVICE	positive pressure ventilation	All participants are ventilated using positive pressure ventilation after negative pressure ventilation

Timeline

• Start date: 2025-10-01
• Primary completion: 2026-10-01
• Completion: 2026-12-01
• First posted: 2025-06-24
• Last updated: 2026-02-18

Locations

1 site across 1 country: Germany