NCT01315782

Alveolar Dead Space as Predictor of Organ Failure in Severe Sepsis

Alveolar Dead Space as Predictor of Multi-organ Failure and Mortality in Medical Intensive Care Patients With Sepsis Requiring Mechanical Ventilation

• Status: Not Yet Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 30 (estimated)
• Sponsor: The University of Texas Health Science Center, Houston · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This is an observational study to understand the changes in alveolar dead space in medical critically ill patients with severe infection (severe sepsis) requiring mechanical ventilation and the possibility to predict multi-organ failure. The measurement of alveolar dead space used to require sophisticated equipment and time. New ventilators have microprocessors that allow rapid mathematical calculation with minimal intervention.

Detailed description

The patient will be followed during their ICU stay up to two weeks while on mechanical ventilation. Patient will be followed daily for the initial 48 hours and then once per week for 2 weeks while mechanically ventilated.

Conditions

• Sepsis
• Severe Sepsis
• Septic Shock
• Multi-organ Failure

Timeline

• Start date: 2026-12-01
• Primary completion: 2026-12-01
• Completion: 2026-12-01
• First posted: 2011-03-15
• Last updated: 2025-06-11

Locations

1 site across 1 country: United States