| Not Yet Recruiting | Alveolar Dead Space as Predictor of Organ Failure in Severe Sepsis NCT01315782 | The University of Texas Health Science Center, Houston | — |
| Not Yet Recruiting | Extended vs. Intermittent Beta-Lactam Infusion in ICU Sepsis NCT07398703 | Assiut University | — |
| Not Yet Recruiting | The Multicentre Prospective Observational Study on the Management of Septic Shock NCT07453901 | Bicetre Hospital | — |
| Not Yet Recruiting | Assessing the Efficacy of Dapagliflozin as a Vasculoprotective Treatment in Septic Shock Patients With Microci NCT07488689 | University Hospital, Strasbourg, France | Phase 3 |
| Not Yet Recruiting | Mechanistic Assessment of Norepinephrine Therapy vs. Angiotensin-II in Septic Shock NCT06746753 | Wake Forest University Health Sciences | Phase 4 |
| Not Yet Recruiting | Early Co-Administration of Crystalloid Fluid and Norepinephrine for Preventing Acute Kidney Injury in Septic S NCT07418541 | Universitas Sumatera Utara | N/A |
| Not Yet Recruiting | Cardiovascular Phenotypes in Sepsis NCT07442032 | Karolinska Institutet | — |
| Not Yet Recruiting | Association Between Muscle L3 CT Scan Muscle Derived Parameters of Muscle Function Upon Intensive Care Unit Ad NCT07483710 | Centre Hospitalier Universitaire de Saint Etienne | N/A |
| Not Yet Recruiting | Assessment of Cardiac Output and Stroke Volume in Septic Shock Patients NCT07321405 | Assiut University | — |
| Not Yet Recruiting | Adjunctive Fludrocortisone in Septic Shock NCT07451886 | Chinese University of Hong Kong | Phase 2 |
| Not Yet Recruiting | Urea-to-Creatinine Ratio as a Marker of Metabolic Transition in Septic Shock: A Comparison With Indirect Calor NCT07412366 | Hospital Sao Domingos | — |
| Not Yet Recruiting | Comparative Efficacy and Safety of Propofol-Ketamine Combination Versus Propofol Monotherapy in Geriatric Pati NCT07530146 | Helwan University | Phase 3 |
| Not Yet Recruiting | Prognostic Power of the VEXUS Score in Septic Shock: Effectiveness in Mortality Prediction NCT07124741 | Antalya Training and Research Hospital | — |
| Recruiting | Veno-arterial Carbon Dioxide Partial Pressure Difference (CO2gap) for Early Resuscitation of Septic Shock NCT07179276 | University Hospital, Clermont-Ferrand | N/A |
| Not Yet Recruiting | Septic Shock Hemodynamic Respond to Volume Resuscitation Versus Vasopressor Administration NCT07438301 | Mahidol University | — |
| Not Yet Recruiting | Validation of the Use of the Arteriovenous Tension Difference in CO2 Under Hyperbaric Conditions NCT07492030 | University Hospital, Lille | — |
| Recruiting | Hydrocortisone and Fludrocortisone for the Treatment of Septic Shock NCT07383103 | Northern Jiangsu People's Hospital | Phase 4 |
| Not Yet Recruiting | Cerebral Hemodynamics and Oxygenation in Critically Ill Patients NCT04690530 | Centre Hospitalier Universitaire de Nice | — |
| Not Yet Recruiting | Early Dexmedetomidine and Sympathetic Regulation in Sepsis NCT07470775 | Sichuan Academy of Medical Sciences | Phase 4 |
| Recruiting | OxiCLEAR (Oxiris Cytokines and Endotoxin Adsorption Rate) Study NCT07419802 | Pauls Stradins Clinical University Hospital | — |
| Not Yet Recruiting | Implementation of Timely Management of Sepsis and Septic Shock Protocol in the Emergency Department and Intens NCT07460024 | Al-Azhar University | N/A |
| Not Yet Recruiting | Phase IIb Multicenter Randomized Controlled Trial Evaluating the Efficacy of Sivelestat in Patients With Septi NCT07214103 | University Hospital, Strasbourg, France | Phase 2 |
| Not Yet Recruiting | Evolution of Tissue Perfusion and Venous Congestion Markers in Fluid-Responsive Septic Shock Patients NCT06958809 | Hospital Ambroise Paré Paris | — |
| Not Yet Recruiting | Extracorporeal Blood Purification Using Oxiris for Septic Shock (EXPLORE Study) NCT07334327 | Pusan National University Yangsan Hospital | N/A |
| Completed | ICU Admission Diagnoses and ICU Mortality NCT07369206 | Ataturk University | — |
| Not Yet Recruiting | Validation of SOFA-2 for Mortality and Sepsis-3 Prevalence in Turkey NCT07300306 | Marmara University | — |
| Not Yet Recruiting | POCUS-Guided Esmolol in Septic Shock: A Pilot RCT NCT07313605 | John Basmaji | Phase 1 / Phase 2 |
| Recruiting | Early Methylene Blue in the Microhemodynamics of Septic Patients NCT07264543 | Centro de Estudos e Pesquisa em Emergencias Medicas e Terapia Intensiva | Phase 2 / Phase 3 |
| Recruiting | External Drainage of Thoracic Duct Lymph to Reduce Inflammatory Cytokines in Septic Shock Patients NCT04855786 | University of Pennsylvania | N/A |
| Not Yet Recruiting | Systematic Adjunction of Vasopressine in Septic Shock NCT07052084 | Assistance Publique Hopitaux De Marseille | Phase 3 |
| Not Yet Recruiting | Early Norepinephrine Administration and Rapid Dose Adjustment NCT07343206 | Siriraj Hospital | N/A |
| Not Yet Recruiting | Outcome of Using Hydrocortisone in Early Treatment of Pediatric Septic Shock NCT07313670 | Muhammad Aamir Latif | N/A |
| Not Yet Recruiting | Early Optimization of Ceftazidime Regimen in Critical Care NCT07085624 | Centre Hospitalier Universitaire de Saint Etienne | N/A |
| Recruiting | Echocardiography-guided Cirrhosis and Liver Failure-Intensive Care Protocol Sepsis NCT07286643 | Post Graduate Institute of Medical Education and Research, Chandigarh | N/A |
| Not Yet Recruiting | Thyroid and Adrenal Disorders in ICU NCT07245550 | Assiut University | — |
| Not Yet Recruiting | Human Albumin for Resuscitation in Surgical Septic Shock: A Randomized Controlled Trial (ALBUS Study) NCT07212582 | Mahidol University | Phase 3 |
| Not Yet Recruiting | Restricted or Liberal Fluid for Haemodynamic Resuscitation in Sepsis NCT05453565 | Australian and New Zealand Intensive Care Research Centre | — |
| Recruiting | Prognosis of Patients With Mixed Cardiogenic-Vasoplegic Shock NCT07354568 | Centre Hospitalier Universitaire, Amiens | — |
| Recruiting | Diagnostic and Prognostic Evaluation of Vasorin During Septic Shock NCT07203833 | Centre Hospitalier Universitaire, Amiens | N/A |
| Not Yet Recruiting | Predictive Model for Multidrug Resistance in Patients Admitted to the Emergency Department With Sepsis NCT07167173 | Hospital Italiano de Buenos Aires | — |
| Recruiting | Use of Vassopresin in Septic Shock Prospective Multicenter Observational Study With Medication NCT07255378 | Jamil Cedeño Mora | — |
| Not Yet Recruiting | Nucleosome Monitoring Relevance for Outcome Prediction in Critically Ill Patients NCT07184593 | Erasme University Hospital | — |
| Recruiting | Weaning Approaches for Vasopressin in Sepsis NCT07067866 | Hospital Nossa Senhora da Conceicao | Phase 3 |
| Recruiting | ARTICE® Real Data Collection & Observational Trial, Phase 4 Study NCT07388628 | Artcline GmbH | — |
| Not Yet Recruiting | IVC Collapsibility Index or CVP as a Predictor of Fluid Responsiveness in Pediatric Sepsis NCT06833333 | Tanta University | N/A |
| Not Yet Recruiting | First in Human Trial to Assess the Feasibility and Preliminary Safety of Adjunctive Treatment with the HemoSys NCT06258291 | hemotune AG | N/A |
| Recruiting | Prediction of Fluid Responsiveness in Paediatric Patients With Septic Shock Using Carotid Doppler Ultrasonogra NCT07136532 | Ain Shams University | — |
| Not Yet Recruiting | Clinical Performance Study of Microbio InfectID-BSI for Detection of Bacteria and Yeast With Patient Blood Sam NCT06531031 | Microbio Co Ltd | — |
| Not Yet Recruiting | Focused Ultrasound Spleen Stimulation and Inflammation in Septic Shock NCT06990295 | First Affiliated Hospital of Wannan Medical College | N/A |
| Not Yet Recruiting | Randomized Control Study in REsuscitation of SEpsis Trial NCT07035509 | Fundación Cardioinfantil Instituto de Cardiología | Phase 4 |
| Recruiting | Empirical Meropenem Versus Piperacillin/Tazobactam for Adult Patients With Sepsis NCT06184659 | Scandinavian Critical Care Trials Group | Phase 4 |
| Completed | Adjunctive Methylene Blue in Septic Shock NCT06900140 | Dr. Shannon M. Fernando | Phase 3 |
| Not Yet Recruiting | Ultrasound-guided Blood Sampling Drawing for Microbiological Analysis in the Critically Ill NCT06156072 | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | — |
| Recruiting | Adrenaline V/s Dopamine in Fuid Refractory Septic Shock NCT07273526 | Laiba Qamar | N/A |
| Active Not Recruiting | Early Continuous Renal Replacement Therapy for Pediatric Septic Shock NCT07370753 | National Children's Hospital, Vietnam | — |
| Not Yet Recruiting | IL-40 and IL-41 Levels in Sepsis, Septic Shock, and Healthy Individuals NCT06963541 | Melahat Yalcin Solak | — |
| Recruiting | Comparison Between Using Cardiometry and IVC Collapsibility NCT07411469 | Menoufia University | — |
| Enrolling By Invitation | Can Gdf-15 Level Predict Progression to Multiple Organ Failure in Patients With Septic Shock NCT06808100 | Ankara City Hospital Bilkent | — |
| Recruiting | Early Versus Late Adjunctive Vasopressin in Septic Shock NCT06709573 | The Cleveland Clinic | Phase 4 |
| Recruiting | Effect of Dynamic Arterial Elastance and Assisted Fluid Management Software Guided Resuscitation in Septic Sho NCT06937918 | Mahidol University | N/A |
| Active Not Recruiting | Critical Closing Pressure and PCO₂ Gap in Fluid Resuscitation for Septic Shock NCT07043192 | Peking Union Medical College | — |
| Not Yet Recruiting | Shenfu Injection Modulates Carotid Elasticity in Septic Shock NCT06915506 | First Affiliated Hospital of Wannan Medical College | Phase 4 |
| Recruiting | Early Angiotensin II in the Emergency Department NCT06693726 | Brett A Faine | Phase 4 |
| Recruiting | Identification of Markers of Poor Clinical Prognosis in Sepsis by Epigenetic Analysis NCT06446947 | Assistance Publique Hopitaux De Marseille | — |
| Not Yet Recruiting | Evaluation of Early Administration of Levetiracetam in the Prevention and Treatment Encephalopathy in Septic S NCT06851078 | Assistance Publique - Hôpitaux de Paris | Phase 3 |
| Recruiting | Atrial Strain in Septic Shock NCT06832436 | Centre Hospitalier Universitaire, Amiens | — |
| Not Yet Recruiting | Evaluating Dynamic Arterial Elastance in Septic Shock Patients. NCT06118775 | Fundación Santa Fe de Bogota | N/A |
| Recruiting | Impact of Vascular Calcification and CASR Expression by Monocytes in Septic Shock NCT06853340 | Centre Hospitalier Universitaire, Amiens | N/A |
| Recruiting | Efficacy of Add-on Plasma Exchange As an Adjunctive Strategy Against Septic Shock NCT05726825 | Hannover Medical School | N/A |
| Recruiting | Study on the Improvement of Microcirculation in Patients With Sepsis by Vitamin B6, Vitamin B12 and Vitamin C NCT06749756 | Fan Zeng | N/A |
| Unknown | Oral Bedtime Melatonin in Critically Ill Patients NCT06156059 | Hospital San Carlos, Madrid | Phase 4 |
| Not Yet Recruiting | Ventriculo-arterial Coupling and Myocardial Work in Sepsis and Septic Shock NCT06853574 | General and Teaching Hospital Celje | N/A |
| Recruiting | Evaluation of Blood Protein O-GlcNAcylation Levels in Children NCT06754696 | Nantes University Hospital | — |
| Recruiting | Renin Levels as Prognostic Indicators of Septic Shock Severity and Outcome NCT06545838 | Federal Research and Clinical Centre of Intensive Care Medicine and Rehabilitology | — |
| Recruiting | In Vivo Antibiotics Removal During Hemoadsorption Cartridges and Continuous Renal Replacement Therapy in the I NCT07230041 | Niguarda Hospital | — |
| Recruiting | Comparison Between Interleukin 6 and Procalcitonin in Detecting Sepsis and Incidence of Mortality in Burn ICU NCT06915974 | Ain Shams University | N/A |
| Recruiting | The PvCO2-PaCO2/CaO2-CvO2 Ratio in Septic Shock NCT07096284 | Avicenna Military Hospital | — |
| Recruiting | Beta-Lactam Antibiotics InitiaL ExpoSure OptimisEd in CriticallY Ill Patients with SEpsis NCT06766461 | Erasmus Medical Center | Phase 4 |
| Completed | Fluid Challenge in Intensive Care The FENICE II Study NCT06394947 | Humanitas Clinical and Research Center | — |
| Recruiting | Peripheral Perfusion Index-guided Fluid Resuscitation for Preventing Acute Skin Failure in Elderly Critically NCT07367113 | Ying Wang | N/A |
| Enrolling By Invitation | Adaptive Blood Purification for the Treatment of Patients With Septic Shock NCT06692036 | Beijing Chao Yang Hospital | N/A |
| Not Yet Recruiting | Venous Excess Ultrasound for Personalized Resuscitation in Septic Shock NCT06696391 | Western University, Canada | Phase 3 |
| Recruiting | Study SOLACE SEPSIS NCT06634069 | University Hospital Pilsen | Phase 2 |
| Recruiting | Norepinephrine and Vasopressin for Rescue Versus Early Vasopressin for Vasopressor Dependent Sepsis NCT06464510 | Hospital do Coracao | Phase 3 |
| Recruiting | Use of Epoetin Alfa and Iron Derisomaltose in Treatment of Anemia in Patients With Sepsis or Septic Shock: a R NCT06670963 | Piotr Czempik | Phase 4 |
| Completed | Different Norepinephrine Doses on Accuracy of Peripheral Perfusion Index in Predicting Tissue Perfusion in Sep NCT07330908 | Tanta University | N/A |
| Completed | Clearance of Antibacterial Agents During Hemoperfusion in Patients With Sepsis NCT06602245 | Efferon JSC | — |
| Recruiting | The Preventive Effect of Shenfu Injection on Myocardial Dysfunction in Sepsis NCT06898723 | First Affiliated Hospital of Wannan Medical College | Phase 4 |
| Recruiting | The Effect of Dexmedetomidine on the Renal Functions in Septic Critically Ill Patients NCT06570187 | Cairo University | Phase 4 |
| Recruiting | Fluid Intolerance Signals as Safety Limits to Prevent Fluid-induced Harm During Septic Shock Resuscitation NCT06568744 | Pontificia Universidad Catolica de Chile | N/A |
| Not Yet Recruiting | OXiris for Abdominal SEptic Shock (OASES Study) NCT06504316 | RenJi Hospital | N/A |
| Recruiting | A Phase III, Open Label, Randomized, Controlled Study of VBI-S in the Treatment of Hypovolemia in Patients Wit NCT06072430 | Vivacelle Bio | Phase 3 |
| Completed | Methylene Blue for the Treatment of Septic Shock NCT06532240 | Northern Jiangsu People's Hospital | Phase 3 |
| Not Yet Recruiting | Echocardiographic Evaluation of RV Injury in the ICU NCT05525936 | Assistance Publique - Hôpitaux de Paris | — |
| Enrolling By Invitation | Impact of the Introduction of a Performance Improvement Program on the Initial Management of Sepsis and Septic NCT06657625 | University Hospital, Brest | — |
| Not Yet Recruiting | The Relation Between Triglyceride- Glucose Index, Procalcitonin and Cardiac Affection in Septic Shock. NCT06518083 | Assiut University | — |
| Recruiting | Norepinephrine Equivalent Dose of Vasopressin, Phenylephrine and Epinephrine in Septic Shock NCT06499467 | Sanjay Gandhi Postgraduate Institute of Medical Sciences | — |
| Recruiting | Evaluation of the Efficiency of Intermittent Enteral Nutrition on Multi-organ Failure From Patients With Mecha NCT06330610 | University Hospital, Rouen | N/A |
| Recruiting | Effects of Intravenous Metabolic Recovery Agent in Elderly Septic Patients on Prognosis and Microcirculation. NCT06723626 | Southeast University, China | N/A |
| Not Yet Recruiting | UK ANDROMEDA-Shock-2 RCT NCT06366854 | Guy's and St Thomas' NHS Foundation Trust | N/A |
| Recruiting | Efficacy and Safety of Methylene Blue in the Treatment of Severe Septic Shock NCT06481410 | First Affiliated Hospital of Zhejiang University | N/A |
| Completed | Association of EASIX in Sepsis NCT06887439 | Sisli Hamidiye Etfal Training and Research Hospital | — |
| Unknown | Dexmedetomidine and Vasopressin in Septic Shock NCT06302998 | Mansoura University | Phase 2 |
| Recruiting | Effect of Early Administration of Albumin 20% Versus Crystalloid NCT06370078 | Egymedicalpedia | N/A |
| Recruiting | Renal Outcomes in the Early Use of Vasopressin in the Treatment of Septic Shock NCT06471231 | Azienda Usl di Bologna | Phase 4 |
| Recruiting | Metabolic Cluster Analysis in Septic Shock Patients NCT06500156 | Corporacion Parc Tauli | — |
| Active Not Recruiting | Blood Purification for the Treatment of Pathogen Associated Shock NCT05011656 | ExThera Medical Corporation | N/A |
| Recruiting | Disseminated Intravascular Coagulation (DIC) Score and Organ Dysfunction in Septic Shock Patients NCT06363149 | Sanjay Gandhi Postgraduate Institute of Medical Sciences | — |
| Completed | Impact of Prior SGLT2 Inhibitors Use on the Development and Progression of Sepsis-Associated Acute Kidney Inju NCT06902493 | University of Jazan | — |
| Completed | The Effect of Early Norepinephrine on Stroke Volume Index, Cardiac Index, Lactate, and Arterial Elastance in P NCT06461390 | Indonesia University | Phase 2 / Phase 3 |
| Not Yet Recruiting | Outcomes of Children After Hospitalization in Intensive Care Unit NCT06124092 | St. Justine's Hospital | — |
| Recruiting | Umbilical Mesenchymal Stromal Cells as Cellular Immunotherapy for Septic Shock NCT05969275 | Ottawa Hospital Research Institute | Phase 2 |
| Withdrawn | Human Albumin Treatment in Adult Septic Shock. A Study Evaluating Immune Response and Organ Failure. NCT05645887 | Albimmune SL | Phase 2 |
| Unknown | Vexus-guided Fluid Management in Patients With Septic Shock After the Resuscitation Phase NCT06227702 | Federal University of São Paulo | N/A |
| Active Not Recruiting | Vasopressin for Septic Shock Pragmatic Trial NCT06217562 | Intermountain Health Care, Inc. | Phase 4 |
| Completed | Multicenter Symphony IL-6 Monitoring Sepsis ICU Study NCT06181604 | Bluejay Diagnostics, Inc. | — |
| Recruiting | The Effect of Vasopressor Therapy on Renal Perfusion in Septic Shock NCT06234592 | King's College Hospital NHS Trust | N/A |
| Suspended | Extracorporal Cytokin Removal in Septic Shock: a Prospective, Randomized, Multicenter Clinical Trial NCT04742764 | University of Pecs | Phase 3 |
| Completed | Vasopressin Use in Septic Shock From Türkiye NCT06953297 | Karadeniz Technical University | — |
| Recruiting | Hemodynamic Response to Angiotensin-II When Used as the Second Vasopressor Agent for Septic Shock NCT06122987 | Kingman Regional Medical Center | Phase 4 |
| Recruiting | Protocolized Reduction of Non-resuscitation Fluids Versus Usual Care in Septic Shock Patients NCT06140147 | Region Skane | N/A |
| Completed | Effect of Simulation Application in Septic Shock Management NCT07032779 | Amasya University | N/A |
| Completed | Strong Albumin Solutions in Patients With Septic Shock NCT05208242 | Manchester University NHS Foundation Trust | Phase 2 / Phase 3 |
| Enrolling By Invitation | Safety and Feasibility of Metformin for Sepsis Induced AKI NCT05900284 | Hernando Gomez | Phase 2 |
| Completed | Medical Device (MD) Derived Pharmacokinetic (PK) Parameters for Vancomycin (MD-PK) NCT05950984 | St George's, University of London | — |
| Recruiting | Clinical Application of Cytokine Adsorption Technique in AIDS Patients With Severe Pneumonia and/or Septic Sho NCT06145828 | Guangzhou 8th People's Hospital | — |
| Unknown | Renal Resistive Index in Septic Shock Patients NCT06214715 | Bezmialem Vakif University | — |
| Unknown | CO2 Gap Changes Versus Inferior Vena Cava Collapsibility in Relation to Cardiac Index as a Prognostic Value in NCT06119815 | Sohag University | N/A |
| Completed | Norepinephrine Administration Through a Midline Catheter in an Intermediate Care Unit NCT06121115 | Region Skane | — |
| Completed | Smart Glasses in Emergency Medicine From the Hangzhou Asian Games NCT06623825 | Sir Run Run Shaw Hospital | — |
| Recruiting | Molecular Subtype-Specific Mechanisms and Therapeutic Strategies in Sepsis NCT06287684 | Mater Dei Hospital, Malta | — |
| Completed | Improvement of Organ Function by Apigenin in Elderly Patients With Sepsis NCT05999682 | Zhujiang Hospital | Phase 1 / Phase 2 |
| Completed | Supplemental Thiamine in Septic Shock: A Before-after Study NCT05840718 | Hospital Sao Domingos | — |
| Unknown | DDX17 Orchestrate Septic Vascular Endothelial Pyroptosis by Controlling Gasdermin D Pore Formation NCT06013033 | Zhongda Hospital | — |
| Recruiting | Evaluation of the Clinical Frailty Scale (CFS) as a Risk Factor of Mortality in Adult Patients ≤65 Years of Ag NCT05928767 | Centre Hospitalier de Lens | — |
| Recruiting | Reducing Empiric VAncomycin Use in Pediatric Suspected Sepsis NCT05975671 | Children's Hospital of Philadelphia | N/A |
| Completed | Hemodynamic Effects of Bolus of Ketamine Versus Fentanyl in Patients With Septic Shock NCT05957302 | Cairo University | N/A |
| Completed | Low Dose Versus High Dose Methylene Blue in Septic Patients NCT06005558 | National Cancer Institute, Egypt | Phase 2 / Phase 3 |
| Completed | Non-Invasive Cardiac Output Monitor (NICOM) for Goal-directed Fluid Resuscitation for Inpatients With Hypotens NCT05630716 | University of Minnesota | N/A |
| Unknown | Evolution of Muscle Function, Breathlessness and Quality of Life Following Intra or Extra-Abdominal Sepsis in NCT06010186 | Fondation Hôpital Saint-Joseph | N/A |
| Completed | The Effect Of Resuscitation Guided By Two Different Dynamic Parameters On Time To Normalization Of The Capilla NCT06122909 | Kasr El Aini Hospital | Phase 3 |
| Completed | Guiding Fluid Resuscitation in Septic Shock: Ultrasound vs. Noninvasive Cardiac Output Monitoring NCT07162857 | Mai Xiaowei | N/A |
| Recruiting | Early Versus Conventional Cessation of Hydrocortisone in Septic Shock NCT05818826 | Mahidol University | Phase 2 |
| Unknown | Red Cell Distribution Width and Lactate Albumin Ratio as Prognostic Markers for Mortality in Sepsis and Septic NCT05921825 | Tanta University | — |
| Recruiting | Effects of Paroxetine on Cardiovascular Function in Septic Patients NCT05725837 | Universidade do Extremo Sul Catarinense - Unidade Academica de Ciecias da Saude | Phase 2 |
| Recruiting | Aminoglycoside Administration in Septic Patients NCT06226441 | University of Thessaly | N/A |
| Completed | MAnual Lymphatic DrAinage to iMprove the outcomE of Patients After Septic Shock NCT05874895 | University Hospital Ostrava | N/A |
| Recruiting | Thoracic Fluid Content During Stabilization and Therapeutic De-escalation in Septic Shock NCT06572995 | University Hospital, Brest | — |
| Recruiting | Therapeutic Plasma Exchange in Septic Shock: A Pilot Study NCT05093075 | University of Manitoba | Phase 2 |
| Unknown | Adjunctive Esketamine for Analgesia in Mechanically Ventilated Septic Shock Patients NCT05839366 | Nanfang Hospital, Southern Medical University | Phase 3 |
| Unknown | Role of Ulinastatin in Preventing Severe Sepsis and Consequent Morbidities and Mortality NCT05895240 | Jinnah Postgraduate Medical Centre | Phase 4 |
| Recruiting | ExtraCorporeal Membrane Oxygenation in the Therapy for REfractory Septic Shock With Cardiac Function Under Est NCT05184296 | Second Affiliated Hospital of Guangzhou Medical University | N/A |
| Unknown | The Construction and Application of Therapeutic System of Intelligent Decision-Oriented Hemodynamic Organized NCT05886192 | Peking Union Medical College Hospital | Phase 4 |
| Completed | Evaluation of the Prognostic Value of Immature Platelet Fraction NCT07039227 | University Hospital, Rouen | — |
| Recruiting | Cardiovascular Effects of Norepinephrine NCT05761522 | CHU de Reims | — |
| Completed | Serum Biomarkers to Predict Response to Angiotensin II in Septic Shock NCT05824767 | University of New Mexico | Phase 4 |
| Completed | Vasopressor Use Improves Macrocirculation, But What Are Its Effects on Microcirculation? NCT07312071 | Gaziosmanpasa Research and Education Hospital | N/A |
| Completed | Impact of Early Sepsis Care Guided by the National Early Warning Score 2 in the Emergency Department NCT05731349 | The University of Hong Kong | N/A |
| Completed | The Prognostic Role of Tricuspid Annular Plane Systolic Excursion in Critically Ill Patients With Septic Shock NCT06008067 | Alexandria University | — |
| Recruiting | Role of Candidate Proteins in Capillary Leakage During Acute Circulatory Failure NCT05586282 | Assistance Publique - Hôpitaux de Paris | — |
| Recruiting | Piperacillin-tazobactam and Temocillin as Carbapenem-alternatives for the Treatment of Severe Infections Due t NCT05565222 | Assistance Publique - Hôpitaux de Paris | Phase 3 |
| Unknown | CharacterisatiON of carDiac funCTion in Intensive Care Unit Survivors of Sepsis. NCT05633290 | NHS Greater Glasgow and Clyde | — |
| Unknown | Assessment of Microcirculatory Dysfunction in Septic Shock Patients by OCTA NCT04593212 | Hospital da Luz, Portugal | — |
| Unknown | Assessing Baseline Cortisol Levels in Patients Admitted With Septic Shock in Intensive Care Unit NCT05741762 | Dr Adnan Agha | — |
| Recruiting | Xanthohumol as an Adjuvant in the Treatment of Septic Shock NCT06225258 | Medical University of Lublin | Phase 2 |
| Completed | Gender-based Differences in the Outcome of the Treatment of Persistent Septic Shock With Hydrocortisone NCT06537180 | Alexandria University | — |
| Completed | Lipopolysaccharide Adsorption (Efferon LPS NEO) in Children With Sepsis NCT05707494 | Efferon JSC | N/A |
| Unknown | Sepsis Early EvaluatioN Through Rapid Ultrasound and veNous Gas Analysis NCT05787184 | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | — |
| Recruiting | Lactate Kinetics in Septic Shock NCT05349370 | Karolinska University Hospital | N/A |
| Unknown | Effect of Metformin Use on Mortality in Diabetic and Non Diabetic Patients With Sepsis and Septic Shock. NCT05572060 | Assiut University | N/A |
| Completed | Midodrine Effect on the Mortality Rates in Septic Shock Patients NCT05778838 | Noha Mansour | Phase 2 |
| Recruiting | Towards Novel BIOmarkers to Diagnose SEPsis on the Emergency Room NCT06178822 | Amsterdam University Medical Centers (UMC), Location Academic Medical Center (AMC) | — |
| Unknown | Clinical Trial Comparing Noradrenaline (NA) Plus Placebo Versus Noradrenaline Plus Terlipressin (TP) in Septic NCT05207280 | Fundación Pública Andaluza para la gestión de la Investigación en Sevilla | Phase 3 |
| Completed | Euthyroid Sick Syndrome in Septic Shock NCT06242626 | Cantonal Hospital Zenica | — |
| Unknown | Mottling Score and Central Venous Oxygen Saturation in Septic Shock Patients NCT05681052 | Erzincan University | — |
| Unknown | Right Ventricular Dysfunction in Septic Shock Patients in ICU NCT05193682 | Shimaa Hammad Ahmed | — |
| Recruiting | Fever Control Using External Cooling in Mechanically Ventilated Patients With Septic Shock NCT04494074 | Centre Hospitalier Intercommunal Creteil | N/A |
| Completed | Temporal Changes of Lactate in CLASSIC Patients NCT05629780 | Karolinska University Hospital | N/A |
| Completed | Diastolic Dysfunction in Septic Shock and Cardiomyopathy Genetic Variants NCT05552521 | Hospital Garcia de Orta | — |
| Unknown | Assessment of Fluid Responsiveness in Septic Shock Patients, Can End-tidal co2 Measurement Help? NCT05557461 | Bozyaka Training and Research Hospital | — |
| Unknown | Impact of Aminoglycosides-based Antibiotics Combination and Protective Isolation on Outcomes in Critically-ill NCT05443854 | Assistance Publique - Hôpitaux de Paris | Phase 3 |
| Completed | Hyperdynamic Left Ventricular Ejection Fraction as a Predictor of Mortality in Intensive Care Unit Patients Wi NCT06993948 | Ain Shams University | — |
| Unknown | eMESH Struct. 2022-23 NCT05202938 | Centre de recherche du Centre hospitalier universitaire de Sherbrooke | — |
| Recruiting | LANdiolol MIcrocirculatory Effects During Septic chOc (MILANOS) NCT04931225 | Assistance Publique - Hôpitaux de Paris | Phase 3 |
| Recruiting | Assessment for Implementation Methods in Sepsis NCT05491941 | Rhode Island Hospital | N/A |
| Recruiting | Evaluation of Parameters Collected From Routine Data for the Diagnosis of Sepsis and Septic Shock and Their In NCT05383963 | Charite University, Berlin, Germany | — |
| Unknown | Effects of Targets of Blood Pressure on Cerebral Hemodynamics in Septic Shock NCT05833607 | D'Or Institute for Research and Education | — |
| Unknown | We Collected Blood Samples From Septic Shock Patients and Measured ELABELA, Creatinine, and NGAL Levels. Survi NCT06001294 | Xiangcheng Zhang | — |
| Completed | Micro and Macro Circulation in Sepsis NCT05694455 | Denver Health and Hospital Authority | N/A |
| Unknown | Carotid Ultrasounds Measurements in Septic Shock NCT05444621 | Assiut University | — |
| Unknown | Effects of Heart Control at Different Stages in Patients of Septic Shock With Tachycardia NCT05389176 | Chinese Medical Association | N/A |
| Unknown | Serum Rennin Kinetics Versus Serum Lactate Kinetics as Predictors of Mortality in Septic Shock Patients NCT05327881 | Assiut University | — |
| Completed | Can Measurement of Neutrophil-derived ROS Production be a Novel Biomarker of Sepsis? NCT05968287 | Gazi University | — |
| Recruiting | CytOSorb TreatMent Of Critically Ill PatientS Registry NCT05146336 | CytoSorbents, Inc | — |
| Unknown | Reliability of PVI Changes During Tidal Volume Challenge in ICU Patients NCT05428423 | Bicetre Hospital | — |
| Unknown | The Role of Serotonin in Intensive Care Patients NCT05386199 | Oslo University Hospital | — |
| Recruiting | ICITRU : Randomized Trial of Immunonutrition With L-citrulline in Patients Hospitalized in Intensive Care for NCT04513288 | Rennes University Hospital | N/A |
| Completed | Hypotension in the Weaning From Vasopressor Drugs NCT05506319 | Hospital Nossa Senhora da Conceicao | Phase 4 |
| Withdrawn | Gram Type Infection-Specific Sepsis Identification Using Machine Learning NCT03734484 | Dascena | Phase 2 |
| Completed | Combined Hemoperfusion and Therapeutic Plasma Exchange for Treatment of Patients With Septic Shock NCT06404424 | Efferon JSC | — |
| Withdrawn | Effects of Norepinephrine and Volume Expansion in Capillary Refill Time in Septic Shock in Angers University H NCT05325957 | University Hospital, Angers | — |
| Completed | Thyroid Hormone Supplementation in Patients With Septic Shock NCT05270798 | Cantonal Hospital Zenica | Phase 2 |
| Unknown | The Efficacy of Adjunctive Use of Ondansetron in Patients With Sepsis and Septic Shock NCT05402553 | Noha Mansour | Phase 1 / Phase 2 |
| Unknown | Efficacy and Safety of Vasopressin Versus Terlipressin as a Second Vasopressor in Critically Ill Cirrhotics Wi NCT05315557 | Institute of Liver and Biliary Sciences, India | N/A |
| Completed | Intravenously Administered M6229 in Critically Ill Sepsis Patients NCT05208112 | A.P.J. Vlaar | Phase 1 |
| Unknown | Unsupervised Machine Learning for Clustering of Septic Patients to Determine Optimal Treatment NCT03752489 | Dascena | Phase 2 |
| Completed | Intravenous Metoprolol in Septic Shock NCT06592547 | Alexandria University | Phase 2 |
| Terminated | Fluid Responseveness in Sepsis and Its Correlation to CVP NCT05612529 | Assiut University | — |
| Suspended | Hemodynamics Effects of Fludrocortisone on the Pressor Response to Noradrenaline Septic Shock Patients NCT05001854 | Rennes University Hospital | Phase 2 / Phase 3 |
| Completed | Decatecholaminisation of Septic Shock With Dexmedetomidine and In-hospital Mortality NCT05283083 | Mansoura University | Phase 2 |
| Terminated | Use of Neurostimulation As a Tool for Reconditioning the Neuromuscular System of Patients Admitted to the ICU NCT05257759 | Centre Hospitalier Universitaire Dijon | N/A |
| Recruiting | Hemodynamic Phenotype and Capillary Refill Time-targeted Resuscitation Strategy NCT05057611 | Pontificia Universidad Catolica de Chile | N/A |
| Completed | Implementation Trial of Predictive Modeling to Enhance Diagnosis and Improve Treatment in Pediatric Septic Sho NCT05065333 | University of Colorado, Denver | N/A |
| Completed | Optimization of Sepsis Therapy Based on Patient-specific Digital Precision Diagnostics NCT04571801 | University Hospital, Essen | N/A |
| Completed | Effect of Norepinephrine Administration on Ventricular Systolic Function in Septic Shock NCT05355961 | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | — |
| Recruiting | Hemodynamic Measurements of Macrocirculatory and Perfusion Parameters in ICU NCT05225402 | Copenhagen University Hospital, Hvidovre | — |
| Unknown | a Novel Index for Tissue Perfusion in Predicting Outcome in Patients With Septic Shock NCT05289388 | Cairo University | — |
| Completed | Effects of Fluid Therapy on Peripheral TIssse Perfusion During Sepsis/Septic Shock NCT05094856 | Assistance Publique - Hôpitaux de Paris | — |
| Completed | Clinical Efficacy of Megadose Vitamin C in Sepsis NCT05194189 | Zhujiang Hospital | Phase 2 |
| Suspended | A RCT to Assess the Performance of CytoSorb for Shock Reversal in Patients With Vasoplegic Septic Shock NCT04963920 | CytoSorbents Europe GmbH | N/A |
| Recruiting | Albumin and Crystalloid Administration in Septic Shock NCT05148286 | Asan Medical Center | Phase 4 |
| Unknown | Nasal and Gut Microbiota Combined Clinical Events Predicts the Prognosis of Septic Patients NCT05143736 | Zhujiang Hospital | — |
| Withdrawn | Angiotensin II vs. Vasopressin in Septic Shock NCT05193370 | University of New Mexico | Phase 4 |
| Unknown | Myocardial Work in Septic Shock Patients NCT05159154 | Humanitas Clinical and Research Center | — |
| Completed | Erythromycin in Septic Patients: Immunomodulatory Role and Clinical Impact NCT04665089 | Tunis University | N/A |
| Completed | Lung Ultrasound-guided Fluid Resuscitation in Neonatal Septic Shock NCT06144463 | Guangdong Second Provincial General Hospital | N/A |
| Completed | Evaluation of Droplet Digital PCR Rapid Detection Method and Precise Diagnosis and Treatment for Suspected Sep NCT05190861 | Huashan Hospital | N/A |
| Unknown | Non Invasive Evaluation of Fluid Responsiveness in Septic Patient NCT05310942 | Benha University | — |
| Unknown | CLinical Efficacy of Hemoperfusion With a Cytokine Adsorber in Norepinephrine-Resistant SEptic Shock NCT05136183 | Mahidol University | N/A |
| Completed | Prognostic Accuracy of qSOFA, SIRS, and EWSs for In-hospital Mortality in Emergency Department NCT05172479 | Aseer Central Hospital | — |
| Completed | Evaluation of Candidate Biomarkers to Predict Disease Severity and Acute Kidney Injury in Sepsis Patients NCT05310812 | Istanbul University | — |
| Unknown | Milrinone Versus Placebo in Patients With Septic Shock NCT05122884 | Mahidol University | Phase 2 |
| Completed | Vitamin C Deficiency in Septic Shock NCT06224881 | Cairo University | Phase 4 |
| Completed | Fluid Resuscitation for Suspected Sepsis in Paediatric Emergency Departments NCT05066464 | Assistance Publique - Hôpitaux de Paris | — |
| Completed | Effect of Ivabradine on Microcirculation and Cardiac Output in Septic Shock Patients NCT05141071 | Cairo University | Phase 2 |
| Completed | Reference Range for abioSCOPE® Device With the PSP Assay in a Generally Healthy Adult Population NCT04409561 | Abionic SA | — |
| Recruiting | Rate, Rhythm or Risk Control for New-onset Supraventricular Arrhythmia During Septic Shock: a Randomized Contr NCT04844801 | Assistance Publique - Hôpitaux de Paris | N/A |
| Unknown | Shock Indices Use for Early Mortality From Septic Shock NCT05088109 | Cairo University | — |
| Unknown | Effect of Immunophenotype on Prognosis of Sepsis NCT05602584 | Southeast University, China | — |
| Unknown | Microcirculation Recruitment Using Albumin 20% and Terlipressin in Septic Patients NCT05080543 | Amany Mousa Salama Muhammed | Phase 1 |
| Unknown | High-dose Intravenous Vitamin C in Patients With Septic Shock NCT04796636 | Melbourne Health | Phase 1 |
| Unknown | Machine Learning Sepsis Alert Notification Using Clinical Data NCT04005001 | Dascena | Phase 2 |
| Unknown | Iron Metabolism Disorders in Patients With Sepsis or Septic Shock. NCT05217836 | Medical University of Silesia | — |
| Unknown | LV Diastolic Function vs IVC Diameter Variation as Predictor of Fluid Responsiveness in Shock NCT05066256 | Mahidol University | N/A |
| Completed | OPTImized Restrictive Strategy Targeting Non-Resuscitative FLUIDs in Septic Shock: Pilot Study. NCT04947904 | Centre Hospitalier Universitaire de Nīmes | N/A |
| Unknown | Septic Shock Management Guided by Ultrasound: SEPTICUS Trial NCT04728529 | Saptadi Yuliarto | N/A |
| Completed | Microcirculation Properties of Albumin for Fluid Resuscitation in Septic Shock NCT05357339 | Rachael Cusack | N/A |
| Withdrawn | Velocity Time Integral vs PICCO for Evaluation of Passive Leg Raising in Septic Shock NCT03621449 | Region Skane | — |
| Unknown | Evaluation of Safety and Dosing of a Vitamin C Bundle for Sepsis Treatment in Africa NCT04999137 | Liverpool School of Tropical Medicine | Phase 2 |
| Completed | RRT With a Cytokine Absorption Filter (oXiris ®) in Patients With Septic Shock NCT04952714 | Clinica CES | — |
| Terminated | Advanced Mesenchymal Enhanced Cell THerapY for SepTic Patients NCT04961658 | Northern Therapeutics | Phase 1 |
| Unknown | Simplified Assessment of Left Ventricular Systolic Function in Septic Shock Patients NCT04963686 | Centre Hospitalier Universitaire, Amiens | — |
| Terminated | Vitamin C, Hydrocortisone and Thiamine in Patients With Septic Shock NCT05192213 | Hospital Sirio-Libanes | Phase 3 |
| Active Not Recruiting | Protocolised Early De-Resuscitation in Septic Shock (REDUCE) NCT04931485 | Insel Gruppe AG, University Hospital Bern | N/A |
| Completed | The Role of Blood Purification by Hemoadsorption as Adjunctive Treatment in Children With Septic Shock NCT05401695 | Chulalongkorn University | N/A |
| Active Not Recruiting | Monocyte Distribution Width (MDW) in the General Population of Emergency Department Patients With and Without NCT05296590 | Henry Ford Health System | — |
| Unknown | The Effect of Early Use of Methylene Blue on Hemodynamics in Septic Shock NCT04970602 | Xiangya Hospital of Central South University | N/A |
| Unknown | Safety and Efficacy of HA380 Hemoadsorption in Patients With Septic Shock NCT04997421 | Turku University Hospital | N/A |
| Unknown | Immune Function Monitoring and Immunotherapy in Sepsis NCT04903405 | Sun Yat-sen University | — |
| Unknown | Artificial Intelligence for Sepsis Prediction in ICU NCT04913181 | Second Affiliated Hospital, School of Medicine, Zhejiang University | — |
| Completed | Early Administration of Vitamin C in Patients With Sepsis or Septic Shock in Emergency Departments NCT04747795 | Universitaire Ziekenhuizen KU Leuven | Phase 3 |
| Terminated | Fluid Resuscitation in Septic Shock Patients With BMI Elevation NCT04759989 | Wake Forest University Health Sciences | N/A |
| Unknown | De-resuscitation Informed by Ultrasound for Patients With Sepsis NCT04921319 | The Miriam Hospital | N/A |
| Unknown | Function of Circulating Exosomes in Sepsis-induced Immunosuppression NCT04979767 | University of Kansas Medical Center | — |
| Recruiting | Effectiveness of Non-invasive Vagus Nerve Stimulation as an Adjuvant Treatment in Patients With Sepsis in Inte NCT04774705 | Assistance Publique - Hôpitaux de Paris | N/A |
| Completed | Lipopolysaccharide Adsorption At Septic Shock NCT04827407 | Efferon JSC | N/A |
| Completed | Bioelectrical Impedance in Monitoring Hyperhydration and Polyneuromyopathy in Critically Ill Patients NCT05991778 | University Hospital Ostrava | — |
| Active Not Recruiting | Ivabradine for Heart Rate Control In Septic Shock NCT04031573 | Assistance Publique - Hôpitaux de Paris | Phase 3 |
| Completed | Fludrocortisone Dose Response Relationship in Septic Shock - FluDReSS NCT04494789 | The George Institute | Phase 2 |
| Unknown | Capillary Refill Time Response to a Rapid Fluid Challenge in Septic Shock Patients NCT04693923 | Pontificia Universidad Catolica de Chile | N/A |
| Recruiting | Comparison of Landiolol Versus Standard of Care for Prevention of Mortality in Patients Hospitalized for a Sep NCT04748796 | Centre Hospitalier Universitaire, Amiens | Phase 3 |
| Unknown | Observed Pharmacokinetic of Piperacillin/Tazobactam Compared to Amikacin in ICU NCT03990467 | Hospices Civils de Lyon | N/A |
| Unknown | Modulation of Endothelial Dysfonction Using Vitamin C in Septic Shock Patients NCT04778605 | Assistance Publique - Hôpitaux de Paris | — |
| Completed | Interstitial Fluid Composition in Patients With Septic Versus Non-septic Shock: an Exploratory Pilot Study NCT05039151 | Centre Hospitalier Universitaire Dijon | — |
| Terminated | A Study Looking at the Use of Biomarkers to Provide Early Indication of Acute Kidney Injury in Patients With S NCT04434209 | BioMérieux | N/A |
| Unknown | Effects of Norepinephrine and Volume Expansion in Capillary Refill Time in Septic Shock NCT04870892 | Bicetre Hospital | — |
| Unknown | Organ-substituting Technologies in the Treatment of Heart and Pulmonary Failure NCT05042622 | National Research Center for Cardiac Surgery, Kazakhstan | N/A |
| Unknown | Evaluation of Plasma Angiotensin II and Angiotensin II Receptor Levels in Patients With Sepsis and Septic Shoc NCT04716842 | Inonu University | — |
| Completed | Coagulation Disturbances in COVID-19 Septic Patients NCT05496816 | Cantonal Hospital Zenica | — |
| Terminated | Comparison of Extubation Delay After Prolonged Sedation NCT04710914 | University Hospital, Rouen | Phase 4 |
| Completed | A STUDY BEFORE/AFTER THE IMPLEMENTATION OF AN ANTI-INFECTIOUS PRESCRIPTION AID NCT05140213 | University Hospital, Montpellier | — |
| Completed | CO2 Gap Changes in Septic Shock in Relation to Cardiac Output NCT05578534 | Cairo University | — |
| Withdrawn | Subpopulation-Specific Sepsis Identification Using Machine Learning NCT03644940 | Dascena | Phase 2 |
| Unknown | A Prediction Model of 28-day Mortality in Septic Shock NCT04915625 | Second Affiliated Hospital, School of Medicine, Zhejiang University | — |
| Unknown | Observational Trial on Cytokine Adsorption in Sepsis NCT04306419 | RWTH Aachen University | — |
| Completed | Pro-inflammatory Role of Blood Platelets in Critically Ill Patients With Septic Shock. NCT04080453 | University Hospital, Bordeaux | — |
| Completed | Rotational Thromboelastometry Versus DIC Score in Sepsis NCT04610853 | University of Leipzig | — |
| Completed | Heamodynamic Effects of Paracetamol in Septic Shock Patients NCT06076980 | Ayah Mohammed Khalil | Phase 4 |
| Completed | Effect of Dexmedetomidine vs Esmolol or Placebo on Cerebral Hemodynamics in Septic Shock NCT06169475 | Xinchen Wang | N/A |
| Completed | Study Assessing Efficacy of Plasmatherapy in Septic Shock-induced Coagulopathy: Feasibility Study NCT04580563 | University Hospital, Strasbourg, France | N/A |
| Completed | Therapeutic Plasma Exchange in Adult Patients With Severe Sepsis NCT04057872 | Alberta Health Services, Calgary | Phase 1 |
| Completed | Renin and Renal Biomarker Response to Angiotensin II NCT04558359 | Alexander Flannery | Phase 4 |
| Completed | Muscle Ultrasound Study in Shock Patients NCT04550143 | University Hospital, Geneva | — |
| Active Not Recruiting | Does High-dose Vitamin B3 Supplementation Prevent Major Adverse Kidney Events During Septic Shock? NCT04589546 | Centre Hospitalier Universitaire, Amiens | Phase 3 |
| Completed | Days Alive and Out of Hospital for Patients With Sepsis NCT04567433 | The George Institute for Global Health, Australia | — |
| Unknown | Optimizing Antibiotic Dosing Regimens for the Treatment of Infection Caused by Carbapenem Resistant Enterobact NCT04516395 | Phramongkutklao College of Medicine and Hospital | N/A |
| Withdrawn | Impact of COVID-19 on the Incidence, Characteristics, Management and Outcome of Sepsis NCT04698382 | National Institutes of Health Clinical Center (CC) | — |
| Recruiting | Study on the Efficacy and Timing of ECMO Therapy in Children With Refractory Septic Shock NCT03948048 | Children's Hospital of Fudan University | — |
| Unknown | Ratio of ''Central Venous-to-Arterial Co2 Gap'' to ''Arterial-to-Central Venous O2 Content Gap'' in Septic Sho NCT04425161 | Ain Shams University | — |
| Unknown | Pharmacokinetics of Amikacin and Cefuroxime in Critically Ill Patients. NCT04470973 | Radboud University Medical Center | — |