NCT07312071

Vasopressor Use Improves Macrocirculation, But What Are Its Effects on Microcirculation?

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (actual)
• Sponsor: Gaziosmanpasa Research and Education Hospital · Other Government
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

To manage the treatment in the intensive care unit for patients with septic shock, central venous oxygen saturation (scvO2) is used as a macrocirculatory indicator, with a target value of 70% or higher being recommended. Tissue oxygenation (stO2) measurement can be implemented to assess the microcirculation in these patients, but a specific target value has not been established yet. The investigators believe that guiding the treatment of septic shock patients based on the measurement of microcirculation using stO2 and evaluating its correlation with scvO2 can reduce mortality. This study aims to investigate the independent impact of high-dose norepinephrine on microvascular reactivity assessed by NIRS-VOT in patients with septic shock, while also examining how these microcirculatory indices relate to the macrocirculatory marker ScvO₂.

Conditions

• Septic Shock
• Sepsis
• Tissue Ischemia
• Hemodynamic Instability

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Vascular Occlusion Test	The vascular occlusion test is a procedure performed to assess the vascular status and perfusion of a limb. It involves temporarily stopping blood flow to the limb by applying a blood pressure cuff.

Timeline

• Start date: 2023-04-01
• Primary completion: 2023-08-31
• Completion: 2023-09-30
• First posted: 2025-12-31
• Last updated: 2025-12-31

Locations

1 site across 1 country: Turkey (Türkiye)