NCT04778605

Modulation of Endothelial Dysfonction Using Vitamin C in Septic Shock Patients

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 30 (estimated)
• Sponsor: Assistance Publique - Hôpitaux de Paris · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Compare the microcirculatory reactivity before and after a 30-minute intravenous infusion of 40 mg/kg vitamin C and evaluate intra-individual variation of hemodynamic parameters between T0 and T1.

Detailed description

This is a transversal study allowing to compare the microcirculatory reactivity before and after a 30-minute intravenous infusion of 40 mg/kg vitamin C. Design: • A monocentric, open-label, transversal study Sample size : 30 patients Assessement: Between 6 hours and 24 hours after admission, the patient will be included after collection of the non opposition. There will be two evaluation times: T0 before the start of vitamin C's perfusion, and T1: 1 hour after the end. No interim analysis is planned. Analysis will be performed at the end of the study after data review and freezing of data base.

Conditions

• Septic Shock

Timeline

• Start date: 2021-01-26
• Primary completion: 2021-07-01
• Completion: 2021-07-01
• First posted: 2021-03-03
• Last updated: 2021-03-03

Locations

1 site across 1 country: France