NCT06234592

The Effect of Vasopressor Therapy on Renal Perfusion in Septic Shock

The Effect of Vasopressor Therapy on Renal Perfusion in Patients With Septic Shock - a Mechanistically Focussed Randomized Control Study

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 45 (estimated)
• Sponsor: King's College Hospital NHS Trust · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Acute kidney injury (AKI) is a common complication of septic shock and together these conditions carry a high mortality risk. In septic patients who develop severe AKI renal cortical perfusion is deficient despite normal macrovascular organ blood flow. This intra-renal perfusion abnormality may be amenable to pharmacological manipulation, which may offer mechanistic insight into the pathophysiology of septic AKI. The aim of the current study is to investigate the effects of vasopressin and angiotensin II on renal microcirculatory perfusion in a cohort of patients with septic shock.

Conditions

• Septic Shock
• Acute Kidney Injury

Interventions

Type	Name	Description
DRUG	Angiotensin II	Angiotensin II infusion
DRUG	Vasopressin	Vasopressin infusion
DRUG	Norepinephrine	Standard care vasopressor therapy, norepinephrine infusion

Timeline

• Start date: 2024-01-05
• Primary completion: 2026-01-01
• Completion: 2026-07-01
• First posted: 2024-01-31
• Last updated: 2025-04-04

Locations

1 site across 1 country: United Kingdom