NCT05778838

Midodrine Effect on the Mortality Rates in Septic Shock Patients

Clinical Study Evaluating the Efficacy and Safety of Adjunctive Use of Midodrine in Septic Shock Patients

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 100 (actual)
• Sponsor: Noha Mansour · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Assessing the safety and efficacy of the adjunctive use of midodrine as a vasopressor in septic shock patients by measuring the difference in the mortality rates between control and intervention groups.

Conditions

• Septic Shock

Interventions

Type	Name	Description
DRUG	Midodrine Oral Tablet	Patients will receive standard treatment in accordance to surviving sepsis campaign guidelines plus oral midodrine 10 mg/ 8 hours till the end of treatment (subject remaining vasopressor-free for 24 consecutive hours) or death.

Timeline

• Start date: 2022-11-07
• Primary completion: 2023-12-22
• Completion: 2024-01-24
• First posted: 2023-03-21
• Last updated: 2025-03-03

Locations

1 site across 1 country: Egypt