NCT07096284

The PvCO2-PaCO2/CaO2-CvO2 Ratio in Septic Shock

Prognostic Value and Kinetics of the PvCO2-PaCO2/CaO2-CvO2 Ratio Compared to Arterial Lactate in the Initial Phase of Septic Shock

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 30 (estimated)
• Sponsor: Avicenna Military Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The ratio of the venous-arterial carbon dioxide partial pressure difference to the arteriovenous oxygen content difference (Pv-aCO₂/Ca-vO₂) may be a marker of anaerobic metabolism in patients with acute circulatory failure. This study aims to assess the prognostic value of the PvCO2-PaCO2/CaO2-CvO2 in the early phase of septic shock.

Detailed description

The ratio of the venous-arterial carbon dioxide partial pressure difference to the arteriovenous oxygen content difference (Pv-aCO₂/Ca-vO₂) may be a marker of anaerobic metabolism in patients with acute circulatory failure. This study aims to compare the kinetics of the PvCO2-PaCO2/CaO2-CvO2 ratio with a classic marker of anaerobic metabolism (arterial lactate) in the early phase of septic shock.

Conditions

• Septic Shock

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	PvCO2-PaCO2/CaO2-CvO2 ratio	Patients diagnosed with septic shock will undergo serial measurements of arterial and venous blood gas analyses, arterial lactate levels, and calculation of the Pv-aCO₂/Ca-vO₂ ratio at predefined time points: H0 (baseline), H2, H6, H12, and H24. Calculation Formulas: 1. Arterial Oxygen Content (CaO₂):CaO2 = SaO2 × Hb × 1,34 + PaO2 × 0,0031 2. Venous Oxygen Content (CvO₂):CvO2 = SvO2 × Hb × 1,34 + PvO2 × 0,0031 3. Pv-aCO₂/Ca-vO₂ Ratio: P(v-a) CO2/C(a-v)O2=(PcvCO2-PaCO2)/(CaO2 -CcvO2).

Timeline

• Start date: 2025-01-05
• Primary completion: 2026-06-30
• Completion: 2026-06-30
• First posted: 2025-07-31
• Last updated: 2026-03-31

Locations

3 sites across 1 country: Morocco