NCT06853574

Ventriculo-arterial Coupling and Myocardial Work in Sepsis and Septic Shock

Changes in Ventriculo-arterial Coupling and Myocardial Work During Treatment of Sepsis and Septic Shock: a Prospective Interventional Study

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: General and Teaching Hospital Celje · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Sepsis is a term which describes an excessive response of the body to an infection and, if not promptly treated, can turn into septic shock a condition in which the organs don't receive enough oxygen to satisfy their needs. The aim of the study is to assess how the treatment of sepsis and septic shock will modify myocardial work and ventriculo-arterial coupling, that can be considered as indicators of ventricular and arterial performance efficacy respectively. Each patient will be treated according to updated guidelines for sepsis and septic shock management, they will voluntarily be enrolled and they can decide to withdraw in each moment without any consequence on their treatment. The investigators, after receiving the consent, will collect patients' data, take blood samples and perform ultrasound measurements and then will start the treatment which can be based on fluids infusion, vasopressors or both. The investigators think that a modern cardiovascular assessment approach can be used to individually set the optimal blood pressure target in sepsis and septic shock with the combined evaluation of myocardial work and ventriculo-arterial coupling.

Conditions

• Sepsis
• Septic Shock

Interventions

Type	Name	Description
DRUG	Fluid therapy	Infusion of 8 ml/Kg/30' or 16 ml/kg/60' of fluids.
DRUG	Noradrenaline infusion	dosage will be titrated in order to obtain mean arterial pressure target

Timeline

• Start date: 2025-02-01
• Primary completion: 2025-06-01
• Completion: 2025-06-01
• First posted: 2025-03-03
• Last updated: 2025-03-03

Locations

1 site across 1 country: Slovenia