NCT06446947

Identification of Markers of Poor Clinical Prognosis in Sepsis by Epigenetic Analysis

Identification de Marqueurs de Mauvais Pronostic Clinique du Sepsis Par Analyse épigénétique.

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 25 (estimated)
• Sponsor: Assistance Publique Hopitaux De Marseille · Academic / Other
• Sex: Male
• Age: 45 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

Sepsis is a multifactorial syndrome characterized by a dynamic course and a clinical outcome dependent on several factors, and responsible for one in five deaths worldwide. The aim of this trial is to identify new prognostic markers for the progression of sepsis to septic shock, by comparing epigenetic markers between patients who have or have not developed severe forms of sepsis. The main objective of this preliminary study is to identify prognostic markers for the progression of sepsis to septic shock, i.e. to compare targeted markers between subjects with sepsis who progress to septic shock versus subjects with sepsis who do not progress to septic shock.

Conditions

• Sepsis Syndrome
• Septic Shock
• Sepsis

Interventions

Type	Name	Description
OTHER	blood sampling	Blood sampling (6ml) on admission and a second on discharge from intensive care.

Timeline

• Start date: 2025-03-20
• Primary completion: 2026-09-30
• Completion: 2026-09-30
• First posted: 2024-06-06
• Last updated: 2026-02-12

Locations

1 site across 1 country: France