NCT06592547

Intravenous Metoprolol in Septic Shock

EFFECT of INTRAVENOUS METOPROLOL TARTRATE on MORTALITY in PATIENTS with SEPTIC SHOCK DUE to VENTILATOR-ASSOCIATED PNEUMONIA Thesis

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 100 (actual)
• Sponsor: Alexandria University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

A RCT designed to assess the effect of giving intravenous beta-blockers in patients with septic shock after achieving hemodynamic stability. The principle of this study is to control heart rate allowing for better diastolic filling and thus better perfusion.

Detailed description

A RCT, conducted at alexandria main university hospital, patients were divided into 2 groups, Control group which received the standard care for septic shock and metoprolol group which recieved intravenous metoprolol then patients were assessed for Blood pressure, heart rate, iv fluids needed, vasopressor doses and 28 days mortality

Conditions

• Septic Shock
• Ventilator Acquired Pneumonia

Interventions

Type	Name	Description
DRUG	Intravenous metoprolol tartrate	An intravenous beta-blockers, recieved FDA approval
OTHER	Standard Care (in control arm)	Standard care according to surviving sepsis campaign

Timeline

• Start date: 2022-04-01
• Primary completion: 2023-12-01
• Completion: 2024-11-10
• First posted: 2024-09-19
• Last updated: 2025-01-29

Locations

1 site across 1 country: Egypt

Regulatory

• FDA-regulated drug study