| Not Yet Recruiting | Alveolar Dead Space as Predictor of Organ Failure in Severe Sepsis NCT01315782 | The University of Texas Health Science Center, Houston | — |
| Recruiting | Recovery From Acute Immune Failure in Septic Shock by Immune Cell Extracorporeal Therapy - Observational Long- NCT06143137 | Artcline GmbH | — |
| Unknown | Role of Ulinastatin in Preventing Severe Sepsis and Consequent Morbidities and Mortality NCT05895240 | Jinnah Postgraduate Medical Centre | Phase 4 |
| Unknown | Symphony IL-6 Study in Patients at Risk of Severe Sepsis NCT05665153 | Bluejay Diagnostics, Inc. | — |
| Withdrawn | Gram Type Infection-Specific Sepsis Identification Using Machine Learning NCT03734484 | Dascena | Phase 2 |
| Recruiting | A Multi-Center Data System and Collaborative Network in China for Severe Infection and Sepsis Children NCT04955210 | Children's Hospital of Fudan University | — |
| Unknown | Unsupervised Machine Learning for Clustering of Septic Patients to Determine Optimal Treatment NCT03752489 | Dascena | Phase 2 |
| Unknown | Machine Learning Sepsis Alert Notification Using Clinical Data NCT04005001 | Dascena | Phase 2 |
| Completed | Sepsis Post Market Clinical Utility Simple Endpoint Study - HUMC NCT04804306 | Beckman Coulter, Inc. | — |
| Unknown | Symphony IL-6 Cutoff Validation Study for Patients at Risk of Severe Sepsis NCT05048927 | Bluejay Diagnostics, Inc. | — |
| Unknown | Symphony IL-6 Cutoff Establishment Study for Patients at Risk of Severe Sepsis Due to COVID-19 NCT05060250 | Bluejay Diagnostics, Inc. | — |
| Active Not Recruiting | Monocyte Distribution Width (MDW) in the General Population of Emergency Department Patients With and Without NCT05296590 | Henry Ford Health System | — |
| Completed | ED Tracking Sheet Implementation NCT05213923 | Dartmouth-Hitchcock Medical Center | N/A |
| Completed | Sepsis Post Market Clinical Utility Simple Endpoint Study - Indiana University Hospital NCT04819035 | Beckman Coulter, Inc. | — |
| Active Not Recruiting | Clinical Study on Monitoring the Plasma Concentration of Ceftazidime-Avibactam in Critically Ill Patients NCT05413343 | First Affiliated Hospital of Zhejiang University | — |
| Enrolling By Invitation | Sepsis Clinical Decision Support [CDS] Master Enrollment Study Protocol NCT05304728 | Beckman Coulter, Inc. | — |
| Withdrawn | Subpopulation-Specific Sepsis Identification Using Machine Learning NCT03644940 | Dascena | Phase 2 |
| Completed | Sepsis Post Market Observational Study and Potential Reduction of Time to Antibiotics - Washington University NCT04353388 | Beckman Coulter, Inc. | — |
| Withdrawn | RCT of Sepsis Machine Learning Algorithm NCT03882476 | Dascena | Phase 2 |
| Unknown | Mannheim Register of Sepsis and Septic Shock NCT05231720 | Universitätsmedizin Mannheim | — |
| Completed | Sepsis Post Market Observational Study and Potential Reduction of Time to Antibiotics - Baylor S&W NCT04291417 | Beckman Coulter, Inc. | — |
| Terminated | Early Metabolic Resuscitation for Septic Shock NCT03895853 | M.D. Anderson Cancer Center | Phase 2 |
| Unknown | Effect of PCR-CRISPR/Cas12a on the Early Anti-infective Schemes in Patients With Open Air Pneumonia NCT04178382 | Chinese Medical Association | N/A |
| Completed | Implementation and Evaluations of Sepsis Watch NCT03655626 | Duke University | N/A |
| Completed | Early Identification and Effective Management of Pediatric Sepsis NCT03996720 | Children's Hospital of Fudan University | — |
| Completed | Evaluation of MDW for Early Detection of Sepsis, Clinical Validity NCT03588325 | Beckman Coulter, Inc. | — |
| Completed | Monitoring of Perfusion in Sepsis and Malaria NCT03641534 | University of Oxford | — |
| Terminated | L-carnitine as an Adjunct Treatment for Septic Shock Patients With Acute Kidney Injury NCT02664753 | Centre Hospitalier Universitaire de Nīmes | Phase 3 |
| Terminated | High Flow Nasal Cannula in Severe Sepsis NCT03334227 | Althaia Xarxa Assistencial Universitària de Manresa | N/A |
| Withdrawn | Vitamin D Status in Patients With Severe Sepsis NCT02684487 | Massachusetts General Hospital | Phase 3 |
| Completed | Predictive algoRithm for EValuation and Intervention in SEpsis NCT03235193 | Dascena | N/A |
| Completed | Efficacy of HFNC Versus NIV for Prevent Reintubation in Sepsis Patients NCT03246893 | Mahidol University | N/A |
| Completed | Restrictive Intravenous Fluids Trial in Sepsis NCT03137446 | Rhode Island Hospital | N/A |
| Completed | Mitochondrial DNA as a Biomarker of Sepsis Severity NCT03077672 | Weill Medical College of Cornell University | — |
| Completed | Platelet-associated Inflammation in Severe Sepsis NCT03029039 | Centre Hospitalier Universitaire de Saint Etienne | — |
| Completed | Effect of a Sepsis Prediction Algorithm on Clinical Outcomes NCT03960203 | Dascena | N/A |
| Completed | A Study of Nivolumab Safety and Pharmacokinetics in Patients With Severe Sepsis or Septic Shock. NCT02960854 | Bristol-Myers Squibb | Phase 1 |
| Completed | An Algorithm Driven Sepsis Prediction Biomarker NCT03015454 | Dascena | N/A |
| Completed | The Vital Signs to Identify, Target, and Assess Level (VITAL) Care Study III NCT02973243 | Philips Healthcare | — |
| Completed | (1,3)-β-D-glucan Based Diagnosis of Invasive Candida Infection in Sepsis NCT02734550 | Center for Sepsis Control and Care, Germany | N/A |
| Unknown | Short-course Antimicrobial Therapy in Sepsis NCT02899143 | Ospedale Santa Maria delle Croci | Phase 2 |
| Unknown | The Benefits of Early Initiation of Continual Renal Replacement Therapy in Patients With Severe Sepsis NCT03141112 | Radovan Uvizl | — |
| Completed | The Efficacy of Si-Ni-Tang (a Chinese Herbal Formula) for Severe Sepsis NCT02777606 | Guangdong Provincial Hospital of Traditional Chinese Medicine | N/A |
| Terminated | Use of Amiodarone in Atrial Fibrillation Associated With Severe Sepsis or Septic Shock NCT02668432 | The University of Texas Health Science Center at San Antonio | Phase 4 |
| Unknown | Descriptive Study of the Evolution in Proportion of Regulatory B Lymphocytes in Patients Hospitalized in Inten NCT03115125 | Centre Hospitalier Universitaire, Amiens | N/A |
| Completed | Pharmacokinetics, Safety, Tolerability and Pharmacodynamics of BMS-986189 in Healthy Subjects NCT02739373 | Bristol-Myers Squibb | Phase 1 |
| Completed | Release of Nociceptin From Granulocytes in Sepsis NCT03037281 | University of Leicester | — |
| Completed | Epidemiology of Sepsis in Turkish ICUs. NCT03249246 | Nur Baykara | — |
| Completed | Effects on Microcirculation of IgGAM in Severe Septic/Septic Shock Patients. NCT02655133 | Università Politecnica delle Marche | Phase 2 |
| Terminated | Safety, Pharmacokinetics and Pharmacodynamics of BMS-936559 in Severe Sepsis NCT02576457 | Bristol-Myers Squibb | Phase 1 |
| Completed | Piperacillin PK Analysis in Severe Sepsis Patients NCT02569086 | University of Aarhus | — |
| Completed | GM-CSF to Decrease ICU Acquired Infections NCT02361528 | Hospices Civils de Lyon | Phase 3 |
| Completed | Quality Improvement in Infection COntrol and Sepsis Management in MOdel Regions NCT02820675 | Center for Sepsis Control and Care, Germany | N/A |
| Completed | Adrenomedullin and Outcome in Severe Sepsis and Septic Shock NCT02393781 | Sphingotec GmbH | — |
| Unknown | Monitoring Devices in Prediction of Fluid Responsiveness in Severe Sepsis and Septic Shock NCT02972827 | Santa Barbara Cottage Hospital | N/A |
| Terminated | Sepsis Assessment in Belgian Emergency Rooms NCT02424721 | Axis Shield Diagnostics Ltd | — |
| Completed | TRIAGE: TRIage of Sepsis At emerGency dEpartment NCT02739152 | BioMérieux | — |
| Completed | Microcirculatory Oxygen Uptake in Sepsis NCT02430142 | Universitätsmedizin Mannheim | — |
| Terminated | Following of Myeloid-derived Suppressor Cells (MDSC) in Severe Sepsis: What Relationship With Systemic Inflamm NCT02903082 | University Hospital, Limoges | — |
| Completed | Targeted Exercise Intervention to Reduce Morbidity and Mortality in Sepsis NCT04938531 | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | N/A |
| Completed | The Role of Dysfunctional HDL in Severe Sepsis NCT02370186 | University of Florida | — |
| Completed | Epidemiology, Acute Management, and Outcomes of Patients With Sepsis Presenting to a Referral Hospital in West NCT02346331 | Duke University | N/A |
| Completed | The Pilot Study of the Efficacy of Polymyxin-B Hemoperfusion in Critically Ill Patients With Severe Sepsis NCT02413541 | Chulalongkorn University | N/A |
| Completed | Echo vs. EGDT in Severe Sepsis and Septic Shock NCT02354742 | Intermountain Health Care, Inc. | N/A |
| Completed | Study of an Electronic Health Record-embedded Severe Sepsis Early Warning Alert NCT02376842 | Stanford University | N/A |
| Unknown | Can the Venus 1000 Help Clinicians Treat Patients With Severe Sepsis or Acute Heart Failure? The CVP Trial NCT02258984 | Mespere Lifesciences Inc. | N/A |
| Completed | Characterization of Non-canonical Way in Inflammasome Monocytes of Patients With Severe Sepsis NCT02539147 | Fondation Hôpital Saint-Joseph | — |
| Terminated | The Effect of Dexmedetomidine on Microcirculation in Severe Sepsis NCT02109965 | National Taiwan University Hospital | Phase 4 |
| Unknown | Inferior Vena Cava Collapsibility Index in Severe Sepsis NCT02195830 | Teesside University | N/A |
| Completed | Prehospital Antibiotics Against Sepsis Trial NCT01988428 | Amsterdam UMC, location VUmc | N/A |
| Completed | Studying Complement Inhibition in Early, Newly Developing Septic Organ Dysfunction NCT02246595 | InflaRx GmbH | Phase 2 |
| Completed | Antibiotic Administration and Blood Culture Positivity in Severe Sepsis and Septic Shock NCT01867905 | University of British Columbia | — |
| Completed | Neutrophil Gelatinase Associated Lipocalin (NGAL) in Urine: Can This Prove to be a Biomarker for Acute Kidney NCT02034240 | Sygehus Lillebaelt | — |
| Unknown | Angiotensin II Antagonist in Severe Sepsis NCT01992796 | University of Salerno | Phase 3 |
| Completed | Therapeutic Effect of Sodium Selenite on Oxidative Stress in Patients With Severe Sepsis NCT02026856 | Pavol Jozef Safarik University | — |
| Completed | Dynamic Changes of Tim-3 on Monocytes and Soluble Tim-3 in Patients With Sepsis NCT02180009 | Chinese PLA General Hospital | — |
| Completed | An Observational Study of the Causes, Management, and Outcomes of Community-acquired Sepsis and Severe Sepsis NCT02157259 | University of Oxford | — |
| Completed | International Multicentre Prevalence Study on Sepsis NCT01943747 | European Society of Intensive Care Medicine | — |
| Completed | Early Use of Norepinephrine in Septic Shock Resuscitation NCT01945983 | Mahidol University | N/A |
| Completed | Lactated Ringer Versus Albumin in Early Sepsis Therapy NCT01337934 | University of Sao Paulo | Phase 3 |
| Completed | Control of Fever in Septic Patients NCT04227652 | University Hospital Ostrava | N/A |
| Completed | Efficacy of Mw Vaccine in Treatment of Severe Sepsis NCT02025660 | Post Graduate Institute of Medical Education and Research, Chandigarh | Phase 2 / Phase 3 |
| Withdrawn | Cerebrovascular Autoregulation in Sepsis, Influence of Renal Replacement Therapy NCT01926301 | Johannes Gutenberg University Mainz | — |
| Unknown | Application of Biomarkers Change to Predict Outcome of Patient With Severe Sepsis NCT02871895 | Chang Gung Memorial Hospital | — |
| Unknown | Application of Stimulated Immune Response Change to Predict Outcome of Patient With Severe Sepsis NCT02887274 | Chang Gung Memorial Hospital | — |
| Completed | Outcomes of Severe Sepsis Patients in Surgical Intensive Care Units NCT01919138 | National Taiwan University Hospital | — |
| Terminated | Effect of Different Electric Muscle Stimulation in Patients With Severe Sepsis and Respiratory Failure NCT01895647 | Mackay Memorial Hospital | N/A |
| Unknown | Efficacy of Melatonin in Patients With Severe Sepsis or Septic Shock NCT01858909 | Aragon Institute of Health Sciences | Phase 3 |
| Completed | Acetaminophen for the Reduction of Oxidative Injury in Severe Sepsis NCT01739361 | Vanderbilt University | Phase 2 |
| Unknown | Electronic Application of a Severe Sepsis Screening Tool and Management Bundle NCT01724463 | University of Tennessee | — |
| Withdrawn | Volume Therapy With Crystalloids and Colloids and Hemodynamic Monitoring in Patients With Severe Sepsis NCT02587078 | Wuerzburg University Hospital | Phase 4 |
| Terminated | Plasma Inducible Nitric Oxide Synthase (iNOS) Assay and Sepsis Study NCT01371929 | Research & Diagnostic Antibodies | — |
| Unknown | Methylene Blue in Severe Sepsis and Septic Shock NCT01797978 | Seoul National University Hospital | Phase 3 |
| Terminated | Investigate the Activity of Endotoxin in Severe Sepsis NCT01957254 | National Taiwan University Hospital | — |
| Completed | Ultrasound Measurement of Reactive Hyperemia in Critical Care NCT01726595 | University of Rochester | — |
| Completed | Phase 3 Safety and Efficacy Study of ART-123 in Subjects With Severe Sepsis and Coagulopathy NCT01598831 | Asahi Kasei Pharma America Corporation | Phase 3 |
| Completed | Examination of the Impact of Better Surveillance and Communication of Patient Deterioration on Patient Related NCT01692847 | Philips Healthcare | — |
| Completed | Simplified Severe Sepsis Protocol-2 (SSSP-2) in Zambia NCT01663701 | Vanderbilt University | N/A |
| Completed | Acute Kidney Injury in Septic Critically Ill Patients : Are Aminoglycosides Really Harmful? NCT01932814 | Université Victor Segalen Bordeaux 2 | — |
| Completed | German Lactat Clearance in Severe Sepsis NCT01929772 | RWTH Aachen University | — |
| Completed | Citrulline in Severe Sepsis NCT01474863 | Vanderbilt University | Phase 2 |
| Completed | The AVERT Sepsis Investigation NCT01968746 | Christiana Care Health Services | — |
| Terminated | Comparison of Ultrasound-guided Versus Blind Insertion of Radial Artery Catheters NCT01663779 | Yale University | N/A |
| Completed | Causes and Factors Associated With Outcomes in Community-acquired Sepsis and Severe Sepsis in Northeast Thaila NCT02217592 | University of Oxford | — |
| Unknown | Outcome Following Vitamin C Administration in Sepsis NCT01590303 | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | Phase 2 |
| Unknown | Prognostic Evaluation Of Severe Sepsis And Septic Shock. Procalcitonin Versus Delta Sofa NCT01841190 | Hospital Sao Domingos | — |
| Completed | Septic cArdiac Deficiency and MenIngococcal seveRe Sepsis NCT02041663 | Assistance Publique - Hôpitaux de Paris | N/A |
| Completed | Effects of Acute Systemic Inflammation on Arterial Stiffness and Microcirculation. NCT01556373 | Rennes University Hospital | — |
| Completed | De-escalation of Empirical Antimicrobial Therapy Study in Severe Sepsis NCT01626612 | Assistance Publique Hopitaux De Marseille | Phase 3 |
| Terminated | Simplified Severe Sepsis Protocol in Zambia NCT01449916 | Vanderbilt University | N/A |
| Terminated | Muscle Atrophy in Patients With Severe Sepsis NCT01717651 | Ohio State University | — |
| Completed | Procalcitonin Monitoring Sepsis Study NCT01523717 | Brahms AG | — |
| Completed | A Prospective Study of The Complement Depletion in Patients With Severe Abdominal Sepsis NCT01568853 | Jinling Hospital, China | N/A |
| Completed | Pharmacokinetic and Biomarker Study of Pioglitazone in Adolescents With Severe Sepsis and Septic Shock NCT01352182 | Children's Hospital Medical Center, Cincinnati | Phase 1 / Phase 2 |
| Unknown | Peripheral Perfusion Targeted Fluid Management NCT01397474 | Erasmus Medical Center | Phase 4 |
| Unknown | Pharmacogenomic Biomarker Study for Recombinant Human Activated Protein C Treatment in Severe Sepsis NCT01486524 | Sirius Genomics Inc. | — |
| Completed | Preemptive Resuscitation for Eradication of Septic Shock NCT01449721 | Christiana Care Health Services | N/A |
| Suspended | Safety and Efficacy of Talactoferrin Alfa in Patients With Severe Sepsis NCT01273779 | Agennix | Phase 2 / Phase 3 |
| Completed | Lotta Alla Sepsi Ospedaliera - Fighting Hospital Sepsis NCT01804764 | University of Milano Bicocca | — |
| Completed | The Effect of Three Different Fluids(Albumin 5%, Normal Saline, Hydroxyethyl Starch 130 kD) on Microcirculatio NCT01319630 | Mercy Research | — |
| Terminated | S.A.F.E.BT System Extracorporeal Treatment With DIAPACT CRRT NCT01312675 | B. Braun Medical Inc. | N/A |
| Completed | The Effect of Ketanserin on the Microcirculation in Sepsis NCT01329887 | Frisius Medisch Centrum | Phase 3 |
| Completed | IMproved PREdiction of Severe Sepsis in the Emergency Department NCT01392508 | Axis Shield Diagnostics Ltd | — |
| Completed | SIRS and Bacterial Sepsis Discrimination by Biomarkers in ICU NCT01378169 | Fondation Hôpital Saint-Joseph | — |
| Completed | Glutamine Supplementation in Critically Ill Patients With Severe Sepsis NCT03048994 | Changi General Hospital | N/A |
| Completed | Early Warning System for Clinical Deterioration on General Hospital Wards NCT01280942 | Washington University School of Medicine | N/A |
| Completed | Efficacy of Hydrocortisone in Treatment of Severe Sepsis/Septic Shock Patients With Acute Lung Injury/Acute Re NCT01284452 | Mahidol University | N/A |
| Terminated | Epidemiology of Septic Shock in Medical or Polyvalent ICU in the North-East Region of France NCT01903746 | Centre Hospitalier Universitaire Dijon | — |
| Completed | A Study to Compare the Efficacy and Safety of 2 Dosing Regimens of IV Infusions of AZD9773 (CytoFab™) With Pla NCT01145560 | AstraZeneca | Phase 2 |
| Unknown | 4G/5G Polymorphism of Plasminogen Activator Inhibitor-1 Gene and Disseminated Intravascular Coagulation in Sev NCT01211899 | Hallym University Medical Center | — |
| Active Not Recruiting | Zinc Therapy in Critical Illness NCT01162109 | University of Vermont | Phase 1 |
| Completed | End-of-life Decision-making in Patients With Sepsis-related Organ Failure NCT01247792 | Center for Sepsis Control and Care, Germany | N/A |
| Completed | A Study to Assess Safety,and Tolerability of 2 Doses of AZD9773 (CytoFab™) in Japanese With Severe Sepsis/Sept NCT01144624 | AstraZeneca | Phase 2 |
| Completed | Sepsis Metabolomics NCT01649440 | Chinese PLA General Hospital | — |
| Withdrawn | Efficacy of Bevacizumab in Preventing Acute Respiratory Distress Syndrome (ARDS) NCT01314066 | Weill Medical College of Cornell University | Phase 2 |
| Unknown | Serum Proteomics Analysis for Sepsis NCT01493466 | Chinese PLA General Hospital | — |
| Terminated | Impact of Early Goal-directed Fluid Therapy in Septic Patients Undergoing Emergency Surgery NCT01654003 | University Hospital, Geneva | N/A |
| Completed | Microcirculatory Changes During Magnesium Sulphate Infusion in Sepsis NCT01332734 | Frisius Medisch Centrum | — |
| Completed | The Effect of Esmolol on Clinical Prognosis of Patients With Severe Sepsis NCT02794025 | Fujian Provincial Hospital | N/A |
| Completed | Scandinavian Starch for Severe Sepsis/Septic Shock Trial NCT00962156 | Anders Perner | Phase 3 |
| Completed | Safety and Efficacy of Procalcitonin Guided Antibiotic Therapy in Adult Intensive Care Units (ICU's) NCT01139489 | Amsterdam UMC, location VUmc | N/A |
| Completed | Placebo Controlled Trial of Sodium Selenite and Procalcitonin Guided Antimicrobial Therapy in Severe Sepsis NCT00832039 | Kompetenznetz Sepsis | Phase 3 |
| Terminated | GCIV as an Adjuvant Therapy for Community-Acquired Severe Sepsis or Septic Shock NCT01315496 | Green Cross Corporation | Phase 3 |
| Completed | Use of Inflammatory Biomarkers to Guide Antibiotic Therapy in Patients With Severe Infections NCT00934011 | Federal University of Minas Gerais | N/A |
| Completed | Activated Protein C and Microcirculation NCT01806428 | Università Politecnica delle Marche | — |
| Completed | Comparison of Total, Salivary and Calculated Free Cortisol Levels in Patients With Severe Sepsis NCT02589431 | TC Erciyes University | — |
| Completed | Fluid Resuscitation in Early Septic Shock NCT00819416 | Ottawa Hospital Research Institute | Phase 2 |
| Unknown | Early Continuous Renal Replacement Therapies (CRRT) in Patients With Severe Sepsis or Septic Shock With Acute NCT00837057 | Asan Medical Center | Phase 4 |
| Completed | Hydrocortisone for Prevention of Septic Shock NCT00670254 | Charite University, Berlin, Germany | Phase 3 |
| Completed | Influence of Acute Respiratory Distress Syndrome (ARDS) and Severe Sepsis on sRAGE Levels in ICU Patients NCT00811629 | University Hospital, Clermont-Ferrand | — |
| Unknown | Pro-inflammatory Cytokines Profile and Mortality Rate of Critically Ill Septic Patients Following Plasmapheres NCT01249222 | Tehran University of Medical Sciences | N/A |
| Unknown | Evaluation of MorphoTEP With the FDG Among Patients in Severe Sepsis of Unspecified Etiology NCT00791310 | Central Hospital, Nancy, France | Phase 3 |
| Unknown | Australasian Resuscitation In Sepsis Evaluation Randomised Controlled Trial NCT00975793 | Belinda Howe | Phase 3 |
| Unknown | Echocardiography in Septic Shock NCT02135796 | Intermountain Health Care, Inc. | — |
| Completed | Septic Encephalopathy and Late Cognitive Dysfunction NCT00772096 | University Hospital, Basel, Switzerland | Phase 4 |
| Completed | Autonomic Nervous System Alteration Induce by Sepsis: Assessment and Prognosis Impact NCT00835913 | University Hospital, Grenoble | — |
| Completed | Volume Replacement With Albumin in Severe Sepsis NCT00707122 | Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico | Phase 3 |
| Completed | Diagnosis of Septicaemia by Detection of Microbial DNA in Blood in Severe Infections NCT00709358 | Assistance Publique - Hôpitaux de Paris | Phase 4 |
| Completed | Efficacy of Thymosin alpha1 for Severe Sepsis NCT00711620 | Sun Yat-sen University | N/A |
| Completed | Safety and Efficacy Study of Recombinant Human Lactoferrin to Treat Severe Sepsis NCT00630656 | Agennix | Phase 2 |
| Completed | Protocolized Care for Early Septic Shock NCT00510835 | University of Pittsburgh | N/A |
| Completed | Endothelium in Severe Sepsis NCT00793442 | Beth Israel Deaconess Medical Center | — |
| Completed | Clinical Assessment of Fish Oil-based Lipid Emulsion Infusions in Critical Patients With Severe Sepsis NCT00634075 | Li Shin Hospital | Phase 4 |
| Completed | AZD9773 Dose Escalation Study NCT00615017 | AstraZeneca | Phase 2 |
| Terminated | Study of Procalcitonin (PCT)-Guided Antibiotic Use in Severe Sepsis Patients Without Obvious Infection NCT01025180 | Brahms France | Phase 4 |
| Completed | Sepsis Institutional Registry in Hospital Italiano de Buenos Aires NCT01403935 | Hospital Italiano de Buenos Aires | — |
| Completed | Comparison of Two Antibiotic Regimen (Meropenem Versus Meropenem+Moxifloxacin)in the Treatment of Severe Sepsi NCT00534287 | Kompetenznetz Sepsis | Phase 3 |
| Completed | Skeletal Muscle and Platelet Mitochondrial Dysfunction During Sepsis NCT00541827 | Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico | — |
| Completed | Clarithromycin as Immunomodulator for the Management of Sepsis NCT01223690 | University of Athens | Phase 3 |
| Completed | The Effects of Eicosapentaenoic Acid (EPA), Gamma-Linolenic Acid (GLA) and Antioxidants in the Treatment of Se NCT00329680 | Fernandes Tavora Hospital | Phase 4 |
| Terminated | Minimally-Invasive Cardiovascular Hemodynamic Optimization (MiCHO) Versus Early Goal-Directed Therapy (EGDT) i NCT00535821 | Loma Linda University | Phase 4 |
| Unknown | Microcirculation Guided Therapy Versus "Standard Treatment" of Severe Sepsis NCT00484133 | Onze Lieve Vrouwe Gasthuis | Phase 4 |
| Completed | Effect of Docosahexaenoic Acid on the Inflammatory Response and Clinical Outcomes From Surgical Patients NCT01049529 | Coordinación de Investigación en Salud, Mexico | Phase 2 |
| Completed | The Utility of Ischemia Modified Albumin (IMA) in Sepsis NCT00448968 | Inverness Medical Innovations | — |
| Completed | Clinical Trial of the Optimal Endpoint of Early Sepsis Resuscitation NCT00372502 | National Institute of General Medical Sciences (NIGMS) | N/A |
| Completed | Evaluate Protein C Levels in Severe Sepsis Patients on Drotrecogin Alfa (Activated) NCT00386425 | Eli Lilly and Company | Phase 2 |
| Unknown | Protocol-driven Hemodynamic Support for Patients With Septic Shock NCT00335907 | National Institute of General Medical Sciences (NIGMS) | N/A |
| Unknown | Pharmacokinetic of Ceftriaxone in Septic ICU Patients NCT00449800 | Association Pour La Promotion A Tours De La Reanimation Medicale | Phase 4 |
| Completed | ACCESS: A Controlled Comparison of Eritoran Tetrasodium and Placebo in Patients With Severe Sepsis NCT00334828 | Eisai Inc. | Phase 3 |
| Terminated | Alterations of Immunologic Mediators During Severe Sepsis NCT00484146 | Klinikum St. Georg gGmbH | — |
| Completed | Investigation of Correlation Between Interstitial and Arterial Blood Glucose Concentrations in Septic Patients NCT00463645 | Medical University of Graz | — |
| Terminated | Near Infrared Spectroscopy (NIRS) in Severe Sepsis NCT00167596 | University of Versailles | Phase 2 / Phase 3 |
| Completed | BaSES Trial: Basel Starch Evaluation in Sepsis NCT00273728 | University Hospital, Basel, Switzerland | Phase 4 |
| Completed | Effect of Hyperglycemia in PAI-1 Activity and the Relationship With Outcome in Severe Sepsis and Septic Shock NCT00159952 | Policlinico Hospital | Phase 2 / Phase 3 |
| Completed | Comparison of Pediatric Septic Shock Treatment With and Without Central Venous Oxygen Saturation Monitoring NCT00407823 | University of Sao Paulo | N/A |
| Completed | Efficacy of Volume Substitution and Insulin Therapy in Severe Sepsis (VISEP Trial) NCT00135473 | SepNet - Critical Care Trials Group | Phase 3 |
| Terminated | Comparative Study of the Protein C Pathway in Septic and Non Septic Patients With Organ Failure NCT00361725 | Assistance Publique - Hôpitaux de Paris | — |
| Completed | An Open Label Study of Severe Sepsis in Adults NCT00568893 | Eli Lilly and Company | Phase 4 |
| Completed | Selenium, as Sodium Selenite, in the Treatment of Septic Shock NCT00207844 | Centre Hospitalier de Meaux | Phase 2 |
| Completed | Norepinephrine Plus Dobutamine Versus Epinephrine Alone for the Management of Septic Shock NCT00148278 | University of Versailles | Phase 2 / Phase 3 |
| Completed | A Non-invasive Approach to the Assessment of Volume Status in Mechanically Ventilated Septic Patients. NCT00398736 | Charite University, Berlin, Germany | — |
| Completed | Extravascular Lung Water Index in Severe Sepsis NCT00986271 | Chang Gung Memorial Hospital | N/A |