NCT01590303

Outcome Following Vitamin C Administration in Sepsis

A Pilot Study Examining the Efficacy of Vitamin C Administration in Septic Patients.

• Status: Unknown
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 20 (estimated)
• Sponsor: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study is designed to determine if Vitamin C administration to septic patients will result in an improvement in organ dysfunction which occurs during a septic illness. Hypothesis: 1. Vitamin C in sepsis will reduce the injury to organs 2. Vitamin C will reduce the length of time on a ventilator, length of stay in the intensive care unit and in hospital.

Detailed description

This study will measure biomarkers of inflammation, coagulation and oxidative stress. These biomarkers have been shown to be increased during periods of oxidative stress eg post-operative, trauma, sepsis. The investigators will determine if Vitamin C administration decreases oxidative stress and as a result, a decrease in the markers of organ dysfunction eg SOFA Scores. Ultimately, if the investigators show a decrease in injury to organs, will this result in a better outcome for patients.

Conditions

• Severe Sepsis

Interventions

Type	Name	Description
DRUG	Vitamin C	Intravenous Vitamin C 1 gram every 8 hours for 28 days or discharge from intensive care unit
DRUG	placebo	placebo vehicle administered to match volume of treatment drug every 8 hours for 28 days or until discharge from ICU

Timeline

• Start date: 2012-05-01
• Primary completion: 2013-06-01
• Completion: 2013-09-01
• First posted: 2012-05-02
• Last updated: 2012-05-02

Locations

1 site across 1 country: Canada