NCT00361725

Comparative Study of the Protein C Pathway in Septic and Non Septic Patients With Organ Failure

Comparative Study of the Protein C Pathway in Septic and Non Septic Patients

• Status: Terminated
• Phase: —
• Study type: Observational
• Enrollment: 90 (planned)
• Sponsor: Assistance Publique - Hôpitaux de Paris · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

This is a comparative study performed in 3 groups of patients/subjects: 30 severe sepsis patients, 30 non-septic patients with organ failure, 30 healthy subjects. The only intervention is a venous blood sampling at the onset of the disease. The purpose of the study is to compare the PC pathway and expression and inflammatory genes between the 3 groups. The main hypothesis is that systemic inflammatory response and exacerbated coagulation activation are non specific of an infection as a triggering event.

Detailed description

analysis of the PC pathway * PC activity * PS activity * soluble thrombomodulin * soluble EPCR * activated protein C * quantitative flow cytometry on monocytes (thrombomodulin and EPCR) * whole blood mRNA (Tissue factor, thrombomodulin and EPCR) * inflammatory gene expression analysis by MLPA

Conditions

• Severe Sepsis
• Organ Failure

Timeline

• Start date: 2003-03-01
• Completion: 2003-10-01
• First posted: 2006-08-08
• Last updated: 2006-08-15