NCT01332734

Microcirculatory Changes During Magnesium Sulphate Infusion in Sepsis

Microcirculatory Changes During Open Label Magnesium Sulphate Infusion in Severe Sepsis and Septic Shock

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 14 (actual)
• Sponsor: Frisius Medisch Centrum · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

During infections (sepsis) bloodflow in small vessels (microcirculation) becomes disturbed. Restoration of bloodpressure and cardiac performance may not be sufficient to correct these alterations. Magnesium is a potent vasodilator which may be used to open up the small vessels, in order to reduce organ failure.

Detailed description

In a single-center open label study we evaluated the effects of magnesium sulphate (MgS) infusion on the sublingual microcirculation perfusion in fluid resuscitated patients with severe sepsis and septic shock within the first 48 hours after ICU admission. Directly prior to and after 1 hour of magnesium sulphate (MgS) infusion (2 gram) systemic hemodynamic variables, sublingual SDF images and standard laboratory tests, were obtained.

Conditions

• Severe Sepsis
• Septic Shock

Interventions

Type	Name	Description
DRUG	Magnesium Sulfate	2 gram in 1 hour

Timeline

• Start date: 2010-03-01
• Primary completion: 2010-08-01
• Completion: 2011-01-01
• First posted: 2011-04-11
• Last updated: 2011-04-11

Locations

1 site across 1 country: Lithuania