NCT03037281

Release of Nociceptin From Granulocytes in Sepsis

Does the Release Profile of Nociceptin From Immunocytes Differ in Healthy Volunteers and Critically Ill Patients With Sepsis?

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 14 (actual)
• Sponsor: University of Leicester · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Nociceptin is a protein found in the body, with a number of functions in the central nervous system, blood vessels and the gut. There is evidence that it may have a role in controlling the immune response to infection, and may act as a link between the brain and immune system. In infection, or after surgery, there is an increase in nociceptin, and subjects greater elevations of nociceptin have a poorer outcome. There is evidence that cells of the immune system may produce nociceptin, although it is not yet known which cells are capable of producing it, and what "switches on" production. This study aims to determine 1. Which cells of the immune system can produce nociceptin 2. If there is a difference in the ability to produce nociceptin between healthy volunteers and patients with severe infections

Conditions

• Sepsis
• Septic Shock
• Sepsis Syndrome
• Severe Sepsis

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Septic	30mls of blood will be sampled by venepuncture, or sampled from indwelling lines (in the case of septic patients on intensive care). Blood will be sampled using standard techniques, and transferred to EDTA containing blood bottles, and undergo processing immediately.

Timeline

• Start date: 2016-04-07
• Primary completion: 2019-06-30
• Completion: 2019-06-30
• First posted: 2017-01-31
• Last updated: 2021-01-06
• Results posted: 2021-01-06

Locations

2 sites across 1 country: United Kingdom