NCT00372502

Clinical Trial of the Optimal Endpoint of Early Sepsis Resuscitation

Lactate Assessment in the Treatment of Early Sepsis: The LactATES Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 300 (actual)
• Sponsor: National Institute of General Medical Sciences (NIGMS) · NIH
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to determine if there is equivalence between two different methods of treating patients with severe bloodstream infection called sepsis. We will randomly assign patients to one of two treatment methods. One of the treatment methods is the current standard of care and uses an infrared sensor on the end of a catheter to determine the adequacy of treatment. The second treatment method is identical to the first but instead of the infrared sensor a blood test that is performed as a part of standard care (with blood drawn from the catheter) will be used to determine the adequacy of treatment. This study will attempt to determine an easier method of guiding treatment.

Conditions

• Severe Sepsis
• Septic Shock

Interventions

Type	Name	Description
PROCEDURE	Modified EGDT	Early goal directed therapy with lactate clearance
PROCEDURE	Standard EGDT	Early goal directed therapy

Timeline

• Start date: 2007-01-01
• Primary completion: 2008-12-01
• Completion: 2008-12-01
• First posted: 2006-09-07
• Last updated: 2009-01-14

Locations

3 sites across 1 country: United States