NCT06847451

Assessment of Red Cell Distribution Width's Prognostic Ability in Septic Intensive Care Unit Patients

Red Cell Distribution Width as a Prognostic Factor for Morbidity and Mortality of Intensive Care Unit Patients With Sepsis.

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 60 (actual)
• Sponsor: Ain Shams University · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

Various biomarkers are used for predicting outcome from sepsis and septic shock, but single value doesn't give a clear-cut picture. This prospective observational study aims to approach the prognostic value of Red Cell Distribution Width for morbidity and mortality of intensive care unit patients with sepsis. and this will be achieved by: * Assessment of prognostic value of red cell distribution width in septic intensive care unit patients for 28 days mortality * Comparison between red cell distribution width and other inflammatory markers as C-reactive protein and serum lactate as well as other scoring systems such as Sequential Organ Failure Assessment (SOFA) score, regarding their prognostic discriminative ability.

Detailed description

Critically ill patients admitted to Ain Shams University hospital intensive care units who fulfill the criteria of sepsis and septic shock according to the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) will be enrolled. All patients will be resuscitated and managed according to Ain Shams University Hospitals protocol for sepsis and septic shock. On admission, and after applying the exclusion and inclusion criteria, all clinical data will be collected from participants, which will mainly include patient's detailed medical history, site of infection, blood routine test, biochemical test, other inflammatory markers as C-reactive protein, Arterial blood gas for serum lactate count, and cultures samples according to source of infection. Red cell distribution width will be recorded for each patient on admission, then patients will be followed up for 28 days mortality. Patient's morbidity will be defined by Sequential Organ Failure Assessment (SOFA) Score, it will be calculated and recorded on admission and will be followed up as well.

Conditions

• Sepsis

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Prognostic biomarker as Red Cell Distribution Width	Assessment of prognostic value of Red Cell Distribution Width in septic intensive care unit patients for 28 days mortality.

Timeline

• Start date: 2024-04-01
• Primary completion: 2024-09-01
• Completion: 2024-09-14
• First posted: 2025-02-26
• Last updated: 2025-03-07

Locations

1 site across 1 country: Egypt