| Not Yet Recruiting | Outside the Cage (OTC) Robotic Esophagectomy NCT06735638 | Centre hospitalier de l'Université de Montréal (CHUM) | Phase 1 |
| Not Yet Recruiting | Pharmacokinetics Study of Larotinib in Subjects With Impaired Hepatic Function NCT05048368 | Sunshine Lake Pharma Co., Ltd. | Phase 1 |
| Not Yet Recruiting | The Value of Near-Infrared Fluorescence Imaging in the Protection of the Recurrent Laryngeal Nerve During Mini NCT07406815 | Fujian Medical University Union Hospital | Phase 3 |
| Not Yet Recruiting | PAravertebral CaTheter Versus Epidural Analgesia in Totally Minimally Invasive Esophagectomies NCT07434739 | University Hospital, Lille | N/A |
| Not Yet Recruiting | Tpex Subsets in Negative Tumor Draining Lymph Nodes for Predicting the Efficacy of PD 1 Inhibitors in Advanced NCT07533357 | Fudan University | — |
| Not Yet Recruiting | Phase 1 Study of PF-08046033 in Advanced Solid Tumors NCT07519655 | Pfizer | Phase 1 |
| Not Yet Recruiting | The Application of Symptoms Management Program Based on the Patient Reported Outcome After Esophagectomy NCT07187154 | Cancer Institute and Hospital, Chinese Academy of Medical Sciences | N/A |
| Recruiting | Comparison of Molecular-Genetic Concordance of the Primary Tumor and Brain Metastases of Gastroesophageal Canc NCT07464470 | Blokhin's Russian Cancer Research Center | — |
| Not Yet Recruiting | Stereotactic Body Radiation Therapy (SBRT) and Immunotherapy for Oligometastatic Esophageal Cancer NCT07330583 | AHS Cancer Control Alberta | Phase 2 |
| Recruiting | Clinical Trial Evaluating TQB6411 Injection in Subjects With Esophageal Cancer NCT07367516 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Phase 1 / Phase 2 |
| Recruiting | Sonesitatug Vedotin in Combination With Capecitabine With or Without Rilvegostomig in Participants With Advanc NCT07431281 | AstraZeneca | Phase 3 |
| Active Not Recruiting | Local Treatment Strategies for Brain Metastases of Gastric and Esophageal Cancer NCT07448493 | Blokhin's Russian Cancer Research Center | — |
| Not Yet Recruiting | Clinical Trial Protocol for Evaluating the Efficacy and Safety of Thoracoabdominal Endoscopic Surgery System i NCT07382635 | Cornerstone Robotics | — |
| Not Yet Recruiting | SL-28 for Advanced Solid Tumours NCT07341737 | Second Life Therapeutics | Phase 1 / Phase 2 |
| Recruiting | EBNK-001 Allogeneic NK Cells With Low-Dose IL-15 ± Pembrolizumab in Advanced Solid Tumors NCT07410676 | Essen Biotech | Phase 1 / Phase 2 |
| Not Yet Recruiting | Application of Toripalimab as Adjuvant Therapy After Esophageal Cancer Surgery: A Multicenter Clinical Trial NCT07332221 | Henan Cancer Hospital | Phase 3 |
| Not Yet Recruiting | Circulating Tumor DNA MRD-Guided Adjuvant Therapy for Curatively Resected Locally Advanced Esophageal Squamous NCT06914011 | Asan Medical Center | Phase 3 |
| Not Yet Recruiting | Indocyanine Green-guided Omental Shield Anastomosis for Cervical Esophagogastric Anastomosis in Minimally Inva NCT07376876 | Daping Hospital and the Research Institute of Surgery of the Third Military Medical University | Phase 2 |
| Not Yet Recruiting | The Value of Indocyanine Green-guided Near-infrared Fluorescence Technology in Tracing Sentinel Lymph Nodes Du NCT07303231 | Fujian Medical University Union Hospital | Phase 3 |
| Not Yet Recruiting | Timing of Minimally Invasive Local Treatment After First-Line Systemic Therapy in Oligometastatic Esophageal o NCT07000253 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | Phase 2 / Phase 3 |
| Not Yet Recruiting | QL1706 Plus Chemotherapy for Borderline Resectable Esophageal Cancer NCT07283991 | Ruijin Hospital | Phase 2 |
| Recruiting | High-Flow Nasal Cannula for Preventing Hypoxia During Sedated Endoscopy in High-Risk Obstructive Sleep Apnea P NCT07307560 | Zhejiang University | N/A |
| Enrolling By Invitation | Based on ctDNA-MRD Guided Adjuvant Treatment Escalation After Definitive Chemoradiotherapy for Unresectable Lo NCT07371247 | The First Affiliated Hospital with Nanjing Medical University | EARLY_Phase 1 |
| Not Yet Recruiting | Optical PD-1 and PD-L1 Imaging in Locally Advanced Esophageal Cancer Using Durvalumab-680LT and Nivolumab-800C NCT07196384 | University Medical Center Groningen | Phase 1 |
| Recruiting | ALDH2 Single Nucleotide Polymorphisms and Prognosis of Esophageal Cancer Patients NCT07322627 | National Taiwan University Hospital | — |
| Not Yet Recruiting | A Multiple Tumor Species, Open and Multi-center Clinical Study of Alpaloritovorelli Antibodies (QL-1706) Combi NCT06760676 | Anhui Provincial Hospital | Phase 1 |
| Not Yet Recruiting | Development and Application of AI-Based Therapeutic Strategies for Esophageal Cancer Integrating Multimodal Im NCT07203690 | Henan Cancer Hospital | — |
| Recruiting | Using 18F-FAPI PET to Detect Metastatic Disease in Patients That Have Gastric or Esophageal Cancer. NCT07217704 | SOFIE | Phase 3 |
| Recruiting | A Study of STRO-004 in Adults With Refractory/Recurrent Metastatic Cancer NCT07227168 | Sutro Biopharma, Inc. | Phase 1 |
| Recruiting | Patient Preference for Subcutaneous vs. Intravenous Immune Therapy NCT07223424 | Diwakar Davar | Phase 2 |
| Not Yet Recruiting | Liquid Nitrogen Spray Cryotherapy Prior to Neoadjuvant Systemic Therapy in Esophageal Adenocarcinoma NCT07222657 | Case Comprehensive Cancer Center | Phase 2 |
| Recruiting | Combination of COMBO Endoscopy Oropharyngeal Airway and HFNC Oxygenation in Sedated Gastrointestinal Endoscopy NCT07175155 | Zhejiang University | N/A |
| Not Yet Recruiting | Consolidation of Toripalimab and Capecitabine After Chemoradiotherapy in ESCC NCT07177794 | Sun Yat-sen University | Phase 3 |
| Recruiting | DESTINY-PANTUMOUR04 NCT07124000 | AstraZeneca | — |
| Recruiting | CEA-Targeted CAR-T Therapy in CEA-Positive Advanced Solid Tumors NCT07179692 | Chongqing Precision Biotech Co., Ltd | Phase 1 |
| Recruiting | Total Neoadjuvant Therapy for Lymph Node-positive Adenocarcinoma of the OESophagus and Oesophagogastric Juncti NCT06161818 | Erasmus Medical Center | Phase 2 |
| Completed | High-flow Nasal Cannula Oxygenation in Sedated Endoscopy for High-risk Obstructive Sleep Apnea Patients NCT07155330 | Zhejiang University | N/A |
| Recruiting | Intraoperative Imaging of Gastrointestinal Malignancies Using Pafolacianine (CYTALUX™) NCT07124351 | Cedars-Sinai Medical Center | Phase 4 |
| Recruiting | A Multi Tumor, Open Phase I Clinical Study on the Progression of First-line Anti-tumor Therapy Using Cardonizu NCT06232083 | Anhui Provincial Hospital | Phase 1 |
| Not Yet Recruiting | Thoraco-laparoscopic Partial Esophagogastrectomy for Management of Esophageal Cancer NCT06879483 | Sohag University | N/A |
| Recruiting | Clinical Application of PET Imaging Targeting CLDN18.2 in Malignant Tumors NCT07301814 | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | — |
| Recruiting | Brachytherapy With Radiotherapy and Immunotherapy: Guided HDR Trial in Esophageal Squamous Cell Carcinoma NCT07152678 | National Taiwan University Hospital | Phase 2 |
| Not Yet Recruiting | Endostatin Adenovirus With Checkpoint Inhibitor in Advanced Head and Neck or Esophageal Cancer NCT07154108 | Sichuan University | Phase 1 |
| Recruiting | IDOV-Immune for Advanced Solid Tumors NCT06910657 | ViroMissile, Inc. | Phase 1 |
| Recruiting | A Study to Evaluate the Safety, Pharmacokinetics and Efficacy of TJ101 in Patients With Advanced/Metastatic So NCT07181473 | Phrontline Biopharma | Phase 1 |
| Recruiting | A Study to Learn About the Study Medicine Called PF-08046876 in People With Advanced Solid Tumors NCT07090499 | Pfizer | Phase 1 |
| Recruiting | Single Dose Investigator Initiated Pilot Study to Investigate CYTALUX (Pafolacianine) for Intraoperative Detec NCT07039526 | John Waters | Phase 2 |
| Recruiting | Development and Validation of a Risk Prediction Model for Gastric Retention in Patients Undergoing Sedated Gas NCT07104214 | Zhejiang University | — |
| Not Yet Recruiting | Radiation-induced Toxicity of the Heart NCT06986291 | Technische Universität Dresden | N/A |
| Recruiting | Oncolytic Virus in Esophageal Squamous Cell Carcinoma NCT07061704 | Sichuan University | Phase 1 / Phase 2 |
| Recruiting | DCRT vs. Surgery in Resectable ESCC Patient Achiving cCR/PR After nCI NCT07162506 | Tianjin Medical University Cancer Institute and Hospital | Phase 2 |
| Recruiting | 64Cu-LNTH-1363S in Patients With Sarcoma or Gastrointestinal Tract Cancer NCT06298916 | Lantheus Medical Imaging | Phase 1 / Phase 2 |
| Recruiting | Integrating Multimodal AI to Predict Treatment Response and Refine Risk Stratification in Esophageal Cancer （R NCT07354295 | Shu Peng | — |
| Recruiting | Incidence of 106TBL Lymph Node Metastasis NCT07165210 | Fudan University | — |
| Recruiting | Incidence of 107 Lymph Node Metastasis NCT07165184 | Fudan University | — |
| Recruiting | Impact of Prehabilitation in Oncology Via Exercise- Esophageal (IMPROVE-Esophageal) NCT06872515 | University of Pittsburgh | N/A |
| Not Yet Recruiting | The Intensive Nutritional Support in Esophageal Cancer Undergoing Neoadjuvant Therapy NCT07067359 | Sichuan University | N/A |
| Not Yet Recruiting | Non-gastric Conduit Reconstruction After Esophagectomy NCT07064655 | Samsung Medical Center | — |
| Completed | Shanghai Clinical Cohort - Esophageal Cancer NCT07312526 | Shanghai Chest Hospital | — |
| Not Yet Recruiting | Optimal Nutritional Palliation of Obstructed GEJ Cancer NCT06876454 | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | N/A |
| Recruiting | PULSO Trial: Pulsed Low-Dose-Rate (PLDR) Radiation Chemoradiation (CRT) vs. Standard CRT for Esophageal Cancer NCT06906887 | Medical College of Wisconsin | Phase 2 |
| Not Yet Recruiting | Proteomic Analysis of Patients Undergoing Bariatric Surgery NCT06787807 | Universidade Federal de Pernambuco | N/A |
| Terminated | A Study of PRT3789 in Combination With Pembrolizumab in Patients With Advanced or Metastatic Solid Tumors With NCT06682806 | Prelude Therapeutics | Phase 2 |
| Not Yet Recruiting | SLND Versus Non-Dissection Following ESD for T1a Stage Esophageal Squamous Cell Carcinoma NCT06979986 | Fujian Cancer Hospital | N/A |
| Recruiting | Investigating Multigene Methylation Dynamics in Treatment Response Surveillance for Esophageal Carcinoma NCT06979869 | Xijing Hospital | — |
| Recruiting | A Study of SH009 Injection in Patients With Advanced Solid Tumors. NCT07390838 | Nanjing Sanhome Pharmaceutical, Co., Ltd. | Phase 1 |
| Recruiting | Chemoimmunotherapy Followed by Surgery for Oligometastatic Esophagogastric Cancer: (TORO Protocol) NCT06668454 | University Health Network, Toronto | N/A |
| Recruiting | Intra-tumoral (IT) Injection of vvDD-hIL2-2-RG-1 for Metastatic Gastrointestinal and Peritoneal Tumors NCT07001592 | Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) | Phase 1 |
| Recruiting | A Study of Bemosubaiabimab Combined With Anlotinib and Radiotherapy and Chemotherapy for the Treatment of Olig NCT07455019 | The First Affiliated Hospital with Nanjing Medical University | Phase 2 |
| Recruiting | A Multicenter Phase II Clinical Study of Neoadjuvant Use of Camrelizumab in Combination With Chemotherapy for NCT06869226 | Peking University Cancer Hospital & Institute | Phase 2 |
| Recruiting | Comparison of Drainage Methods in Minimally Invasive Esophagectomy (DEMURE） NCT07004634 | Ruijin Hospital | N/A |
| Recruiting | Lead-212 PSV359 Therapy for Patients With Solid Tumors NCT06710756 | Perspective Therapeutics | Phase 1 / Phase 2 |
| Recruiting | A Study of MT-4561 in Patients With Various Advanced Solid Tumors NCT06943521 | Tanabe Pharma America, Inc. | Phase 1 / Phase 2 |
| Recruiting | COMBO Endoscopy Oropharyngeal Airway Reduces Hypoxia During Sedated Gastrointestinal Endoscopy in Obese Patien NCT06796764 | Zhejiang University | N/A |
| Recruiting | Developing an Ecological and Tailored Nutritional Intervention to Improve Quality of Life in Esophageal Cancer NCT07024849 | Samsung Medical Center | N/A |
| Not Yet Recruiting | Prognostic Analysis of Esophageal Cancer with Complete Pathological Response After Neoadjuvant Therapy NCT06889402 | Cancer Institute and Hospital, Chinese Academy of Medical Sciences | — |
| Recruiting | Prospective Evaluation of Cornerstone Robotics Sentire Surgical System in Major Gastrointestinal and Urologic NCT06926374 | Chinese University of Hong Kong | N/A |
| Recruiting | Brodalumab in the Treatment of Immune-Related Adverse Events NCT06673329 | Brian Henick, MD | Phase 1 |
| Not Yet Recruiting | ProSight: a Multi-centre Interventional Study Evaluating MCED in Asymptomatic Population NCT06790355 | Shanghai Weihe Medical Laboratory Co., Ltd. | N/A |
| Not Yet Recruiting | Evaluation of Neoadjuvant Therapy Efficacy and Postoperative Pathological Indicators in Esophageal Cancer Usin NCT06833775 | Henan Cancer Hospital | — |
| Recruiting | Chemoradiation Plus Iparomlimab Consolidation in Older With ESCC NCT07038629 | Tianjin Medical University Cancer Institute and Hospital | Phase 2 |
| Recruiting | Patient Derived Organoids (PDOs) to Observe the Clinical Consistency of Personalized Neoadjuvant Therapy for R NCT07054086 | Shanghai Zhongshan Hospital | — |
| Recruiting | Impact of CES1 Genotype on Capecitabine Exposure in Cancer Patients NCT07114627 | Erasmus Medical Center | — |
| Completed | COMBO Endoscopy Oropharyngeal Airway in Sedated Gastrointestinal Endoscopy for Obese Patients NCT06804876 | Zhejiang University | Phase 2 |
| Completed | Combination COMBO Endoscopy Oropharyngeal Airway With High-Flow Nasal Cannula Oxygenation in Sedated Gastroint NCT06812403 | Zhejiang University | Phase 2 |
| Not Yet Recruiting | Mechanistic Study on the Diagnosis of Esophageal Cancer Lymph Node Metastasis Using Spectral CT, Multimodal MR NCT06818214 | Henan Cancer Hospital | — |
| Recruiting | A Phase II Clinical Study to Evaluate HLX43 in Patients With Recurrent/Metastatic ESCC Failed or Intolerance t NCT06769113 | Shanghai Henlius Biotech | Phase 2 |
| Recruiting | A Phase 2 Study of Zanidatamab in Patients With HER2-expressing Tumors NCT06695845 | Jazz Pharmaceuticals | Phase 2 |
| Recruiting | Pan-tumor MRD Study NCT06605404 | Paradigm Health | — |
| Enrolling By Invitation | Luso-Cor Stent Compared to Other Endoscopic Techniques for Management of Fistulas and Anastomotic Dehiscences( NCT06862479 | Unidade Local de Saúde Santa Maria | — |
| Recruiting | Precision Palliative Care for Patients With Advanced Esophageal Cancer NCT06787313 | Fudan University | — |
| Not Yet Recruiting | Safety and Efficacy Study of Pulsed Electric Field (PEF) Therapy in Patients With Advanced or Unresectable Eso NCT06756841 | Energenx Medical LTD. | N/A |
| Recruiting | A Multicenter Prospective Study Evaluating Concurrent Chemoradiotherapy Following Induction Immunochemotherapy NCT06792786 | The Central Hospital of Lishui City | N/A |
| Completed | Retrospective Evaluation of Nivolumab in Adjuvant Esophageal Cancer/Gastroesophageal Junction Cancer NCT06499298 | Bristol-Myers Squibb | — |
| Recruiting | Effect of Premedication With Pronase on Mucosal Cleanliness During EGD NCT06713421 | Changhai Hospital | N/A |
| Recruiting | EQUITY GI: A Prospective Study to Enhance Quality, Inclusivity, and Trial Participation in Black Patients With NCT06263088 | Case Comprehensive Cancer Center | N/A |
| Not Yet Recruiting | Effect of Feeding Jejunostomy on Sarcopenia in Patients with Esophageal Cancer NCT06712706 | Stefan Gutknecht | — |
| Recruiting | DCE-MRI Based on 4D Free Breathing for Predicting Preoperative Neoadjuvant Chemoradiotherapy for Esophageal Ca NCT06755866 | Yunnan Cancer Hospital | N/A |
| Recruiting | Comparison of Endoscopy and Esophagram for the Routine Evaluation of Anastomosis After McKeown Esophagectomy NCT07043491 | Sun Yat-sen University | — |
| Active Not Recruiting | Cola Ingestion for Esophageal Bolus Impaction NCT06652620 | Fudan University | N/A |
| Not Yet Recruiting | Reirradiation Dose Escalation in Thoracic Cancers NCT06558175 | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | Phase 1 |
| Recruiting | Perioperative SDD to Prevent Infectious Complications After Esophagectomy NCT05865743 | Radboud University Medical Center | Phase 3 |
| Recruiting | AI-Assisted Non-Contrast CT for Multi-Cancer Screening NCT06632886 | Guo ShiWei | N/A |
| Recruiting | Endoluminal Vacuum Therapy to Prevent Anastomotic Leakage After Esophagectomy Due to Esophageal Cancer NCT06097078 | Aesculap AG | — |
| Recruiting | Adebrelimab Neoadjuvant Treatment for Resectable ESCC: 2 vs 4 Cycles Study NCT06663059 | Tang-Du Hospital | Phase 2 |
| Not Yet Recruiting | Tislelizumab Combined With Chemotherapy or Radiotherapy in the Treatment of Advanced or Recurrent Metastatic E NCT05628610 | Fujian Cancer Hospital | Phase 2 |
| Recruiting | Substudy 06C: A Study of Investigational Agents With Pembrolizumab (MK-3475) and Chemotherapy in Participants NCT06469944 | Merck Sharp & Dohme LLC | Phase 1 / Phase 2 |
| Not Yet Recruiting | Hematoporphyrin Photodynamic Therapy for Esophageal Cancer NCT06437288 | Sun Yat-sen University | Phase 4 |
| Active Not Recruiting | BEST-RPP Pilot: Screening for Esophageal Cancer in Rural Oregon Without an Endoscopy NCT06335966 | OHSU Knight Cancer Institute | — |
| Recruiting | TIL Therapy Combined With Pembrolizumab for Advanced or Metastatic Refractory Stomach and Esophageal Cancer NCT06532799 | Essen Biotech | Phase 1 / Phase 2 |
| Recruiting | 18F-AraG PET/CT as a Non-Invasive Imaging Biomarker for Chemoradiation Treatment Response in Esophageal Cancer NCT06414902 | M.D. Anderson Cancer Center | Phase 1 |
| Recruiting | Registry for Esophageal and Gastroesophageal Junction Cancer NCT06558786 | Memorial Sloan Kettering Cancer Center | — |
| Recruiting | Substudy 06D: Combination Therapies in Second Line (2L) Gastroesophageal Adenocarcinoma (MK-3475-06D/Keymaker- NCT06445972 | Merck Sharp & Dohme LLC | Phase 1 / Phase 2 |
| Recruiting | Molecular Analysis for Gastro-Esophageal Cancer: Multicenter Discrete Choice Experiment NCT06346080 | KU Leuven | N/A |
| Not Yet Recruiting | Liposomal Irinotecan and 5-FU as Second-line Therapy for Patients With ESCC NCT06501664 | Rui-hua Xu, MD, PhD | Phase 3 |
| Recruiting | Molecular Assessment for Gastro-Esophageal Cancer NCT06346054 | KU Leuven | N/A |
| Recruiting | A Study of BL-M17D1 in Patients With Locally Advanced or Metastatic HER2 Positive/Lower Expression Gastrointes NCT06500052 | Sichuan Baili Pharmaceutical Co., Ltd. | Phase 1 |
| Recruiting | INSPIRE: a Multi-Cancer Early Detection Study NCT06440018 | Singlera Genomics Inc. | — |
| Recruiting | MRD-Guided Consolidation Therapy Following Definitive Radiotherapy in Esophageal Cancer NCT06498752 | Cancer Institute and Hospital, Chinese Academy of Medical Sciences | Phase 2 |
| Not Yet Recruiting | Adebrelimab in Combination With Apatinib and Chemotherapy/Chemoradiotherapy in Immuno-experienced Second-line NCT06464614 | The First Affiliated Hospital of Henan University of Science and Technology | Phase 2 |
| Recruiting | Trilaciclib Combined With Concurrent Chemoradiotherapy and Immunotherapy in the Treatment of Esophageal Cancer NCT06569459 | The First Affiliated Hospital with Nanjing Medical University | Phase 2 |
| Not Yet Recruiting | Evaluation of the Effectiveness of the Combined Psychological Resilience and Self-efficacy Intervention for Im NCT06484842 | Anhui Medical University | N/A |
| Recruiting | A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors NCT06465069 | Eli Lilly and Company | Phase 1 |
| Recruiting | Effectiveness of Risk-based Sequential Screening for Esophageal and Gastric Cancer NCT06306755 | Peking University Cancer Hospital & Institute | N/A |
| Recruiting | Focal Cryoballoon Ablation for Malignant Dysphagia NCT06618742 | Laura Boer | N/A |
| Active Not Recruiting | POP-UP: a Single-arm, Two-cohort Study: an 8-week Trimodal Pre-habilitation Program for Patients With Pancreat NCT06275737 | GERCOR - Multidisciplinary Oncology Cooperative Group | N/A |
| Recruiting | Induction Immunochemotherapy Followed by Concurrent Chemoradiotherapy in Patients With ESCC. NCT06452602 | Tianjin Medical University Cancer Institute and Hospital | Phase 2 |
| Not Yet Recruiting | Neoadjuvant Immunochemotherapy for Adenocarcinoma of the Esophagogastric Junction NCT06469060 | Shanghai Chest Hospital | Phase 2 |
| Recruiting | Neoadjuvant PD-1 Blockade for Elderly Esophageal Squamous Cell Carcinoma (BLESS) NCT06385730 | Shanghai Chest Hospital | Phase 2 |
| Recruiting | Dose Escalation and Dose Expansion Study of MDX2001 in Patients With Advanced Solid Tumors NCT06239194 | ModeX Therapeutics, An OPKO Health Company | Phase 1 / Phase 2 |
| Recruiting | Sintilimab After Concurrent Chemoradiotherapy in Elderly Patients With Esophageal Squamous Cell Carcinoma NCT06413342 | Zhejiang Cancer Hospital | Phase 2 |
| Not Yet Recruiting | Early Detection of Esophageal Squamous Cancer With the Capsule Sponge Device NCT06418516 | Centre of Postgraduate Medical Education | N/A |
| Recruiting | Exercise Prehabilitation for Locoregional Esophageal Cancer NCT06430346 | H. Lee Moffitt Cancer Center and Research Institute | N/A |
| Not Yet Recruiting | Hyperthermia Enhanced Re-irradiation of Loco-regional Recurrent Tumors NCT04889742 | Charite University, Berlin, Germany | Phase 2 |
| Recruiting | An Organ Preservation Strategies After Chemoradiotherapy Combined With Immunotherapy for Esophageal Cancer (PA NCT06339060 | Ruijin Hospital | Phase 3 |
| Not Yet Recruiting | Discovering Patterns in Experiences of Patients in Esophageal Cancer Clinical Research NCT05831150 | Power Life Sciences Inc. | — |
| Recruiting | Myosteatosis in Oeso-gastric Cancer: Clinical Impacts NCT06419244 | Cliniques universitaires Saint-Luc- Université Catholique de Louvain | N/A |
| Recruiting | Induction Chemoimmunotherapy Combined With Chemoradiotherapy in Esophageal Cancer NCT06421376 | Cancer Institute and Hospital, Chinese Academy of Medical Sciences | Phase 2 |
| Not Yet Recruiting | Development and Initial Application of a Combined Exercise and Psychological Intervention Program for Patients NCT06366685 | Mengmeng Yuan | N/A |
| Active Not Recruiting | Clinical Study on the Impact of Eradication of Oral Porphyromonas Gingivalis on the Prognosis of Early Esophag NCT06722300 | The First Affiliated Hospital of Henan University of Science and Technology | N/A |
| Recruiting | Safety and Efficacy of Neoadjuvant Immunochemotherapy in Elderly Patients With Resectable Esophageal Cancer NCT06403878 | Sichuan University | Phase 2 |
| Recruiting | A Phase II Clinical Study of Epigallocatechin-3-gallate in Patients With Esophageal Squamous Cancer NCT06398405 | Shandong Cancer Hospital and Institute | Phase 2 |
| Recruiting | Conebeam CT-based Online Adaptive Radio-Therapy for Esophageal Cancer (ARTEC) NCT06361043 | Insel Gruppe AG, University Hospital Bern | — |
| Unknown | Preoperative Arterial Embolization Before Oncologic Esophagectomy as a Technique for Ischemic Gastric Conditio NCT06312839 | Centre Hospitalier Universitaire de Saint Etienne | — |
| Enrolling By Invitation | Evaluation of [18F]AlF-NOTA-PCP2 PET/CT for PD-L1 Detection in Malignant Tumors NCT06690216 | Man Hu | Phase 1 / Phase 2 |
| Unknown | Perioperative Adebrelimab and Chemotherapy in Esophageal and Esophagogastric Junction Carcinoma NCT06198465 | Xijing Hospital | Phase 2 |
| Unknown | Plasma Metabolic Biomarkers for Multi-Cancer Diagnosis NCT06363123 | Beijing Friendship Hospital | — |
| Completed | The Effects of Acupressure on Improving Postoperative Gastrointestinal Symptom Distress in Esophageal Cancer P NCT06275165 | CHEN, CHIA-CHEN | N/A |
| Active Not Recruiting | Magnetic Sentinel Lymph Node Mapping in Upper Gastro-Intestinal Cancer: A Feasibility Clinical Investigation NCT05899985 | Ferronova Pty Ltd | N/A |
| Completed | Morbidity and Mortality After Esophageal and Esophagogastric Junction Cancer Surgery NCT06277921 | P. Herzen Moscow Oncology Research Institute | — |
| Active Not Recruiting | A Study of LY4101174 in Participants With Recurrent, Advanced or Metastatic Solid Tumors NCT06238479 | Eli Lilly and Company | Phase 1 |
| Recruiting | A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors NCT06172478 | Daiichi Sankyo | Phase 2 |
| Recruiting | Pembrolizumab Combined With Preoperative Chemotherapy (Albumin Paclitaxel+Carboplatin) Neoadjuvant Therapy for NCT06304350 | Tongji University | Phase 2 |
| Recruiting | Open Label Study to Evaluate BL-M07D1 in HER2 Expressing Malignant Solid Tumors NCT06293898 | SystImmune Inc. | Phase 1 |
| Recruiting | Serologic Response to Pneumococcal Vaccination Among Esophageal Cancer Patients With High Grade Lymphopenia Af NCT06181656 | M.D. Anderson Cancer Center | — |
| Recruiting | A Study of Pembrolizumab With Trastuzumab and Chemotherapy in People With Esophagogastric Cancer NCT06123338 | Memorial Sloan Kettering Cancer Center | Phase 2 |
| Enrolling By Invitation | Clinical Trial to Evaluate the Efficacy and Safety of a Thoracic and Abdominal Endoscopic Surgical System NCT06587152 | Cornerstone Robotics | N/A |
| Completed | Evaluations of Alcohol Warning Labels NCT06129487 | University of Connecticut | N/A |
| Completed | Mind Over Matter for Black and African American Women: A Single Arm Trial Examining Feasibility and Acceptabil NCT06168825 | Inova Health Care Services | — |
| Recruiting | The Efficacy and Safety of the COMBO Endoscopy Oropharyngeal Airway in Gastrointestinal Endoscopy Procedure NCT06081647 | RenJi Hospital | N/A |
| Active Not Recruiting | First-in-human Interleukin-15-transpresenting Wilms' Tumor Protein 1-targeting Autologous Dendritic Cell Vacci NCT05964361 | University Hospital, Antwerp | Phase 1 / Phase 2 |
| Withdrawn | Evaluation of the Autonomic Nervous System in Patients Undergoing Esophagectomy for Cancer NCT04835987 | Centre Hospitalier Universitaire de Saint Etienne | — |
| Completed | Esophageal Cancer Multimodal Prehabilitation Study NCT06027515 | Massachusetts General Hospital | N/A |
| Completed | A Study of the Tumor Microenvironment Affecting the Efficacy of Immunotherapy for Esophageal Cancer NCT06219031 | Renmin Hospital of Wuhan University | — |
| Unknown | Treatment Pleural Carcinosis of Pressurized IntraThoracic Hyperthermic Aerosol Cisplatin Administration NCT06281860 | Dr Jean Yannis PERENTES | Phase 1 |
| Recruiting | A Study of SI-B003, BL-B01D1+SI-B003 and BL-B01D1+PD-1 Monoclonal Antibody in Patients With Locally Advanced o NCT06008054 | Sichuan Baili Pharmaceutical Co., Ltd. | Phase 2 |
| Active Not Recruiting | A Study to Evaluate LBL-007 in Combination With Tislelizumab Plus Chemotherapy in Participants With Unresectab NCT06010303 | BeiGene | Phase 2 |
| Not Yet Recruiting | Surveillance After Resection of Oesophageal aNd Gastric Cancer (SARONG-II) Trial NCT06115629 | University of Dublin, Trinity College | Phase 3 |
| Recruiting | Safety and Efficacy of NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Brain Meta NCT06047379 | Neonc Technologies, Inc. | Phase 1 / Phase 2 |
| Active Not Recruiting | Study of AB598 Monotherapy and Combination Therapy in Participants With Advanced Cancers NCT05891171 | Arcus Biosciences, Inc. | Phase 1 |
| Unknown | G-POEM for Refractory Gastroparesis After Esophagectomy With Gastric Pull-through NCT06068127 | Institute for Clinical and Experimental Medicine | — |
| Recruiting | Online Adaptive Radiotherapy Using a Novel Linear Accelerator (ETHOS) NCT06116019 | Charite University, Berlin, Germany | — |
| Recruiting | Tislelizumab Plus Concurrent Chemoradiation in Older With ESCC NCT06061146 | Tianjin Medical University Cancer Institute and Hospital | Phase 2 |
| Recruiting | Locally ablatIVe thErapy for oLigo-progressive gastrOintestiNal maliGnancies (LIVELONG) NCT06101277 | University of California, Davis | N/A |
| Completed | Raman Probe for In-vivo Diagnostics (During Oesophageal) Endoscopy NCT03468634 | University of Exeter | N/A |
| Unknown | Dynamic Follow-up of Symptoms Based on Patient-reported Outcomes in Immunotherapy for Esophageal Cancer: a Pro NCT06012318 | Guangdong Provincial People's Hospital | — |
| Recruiting | CEA Targeting Chimeric Antigen Receptor T Lymphocytes (CAR-T) in the Treatment of CEA Positive Advanced Solid NCT06006390 | Chongqing Precision Biotech Co., Ltd | Phase 1 / Phase 2 |
| Recruiting | Personalized Nutrition Counseling and Nutritional Status of Esophageal Cancer and HNSCC Patients Undergoing CC NCT06829095 | Chang Gung Memorial Hospital | — |
| Recruiting | CPAP for Esophageal Cancer With Radiotherapy NCT06037902 | Sheba Medical Center | N/A |
| Recruiting | Evaluate BL-B01D1 in Patients With Metastatic or Unresectable Non-Small Cell Lung Cancer (NSCLC) and Other Sol NCT05983432 | SystImmune Inc. | Phase 1 |
| Completed | The Effect of Prophylactic TPO Combined with BMS-IMRT to Esophageal Cancer Patients NCT05944809 | JIANYANG WANG | Phase 2 |
| Recruiting | a Single-arm, Single-center, Open Clinical Study NCT06431100 | Beijing Geekgene Technology Co., LTD | — |
| Active Not Recruiting | Adjuvant Trastuzumab Deruxtecan (Enhertu) & Nivolumab For Patients Who Are Disease Free After Completion of Tr NCT05480384 | Brown University | Phase 2 |
| Active Not Recruiting | Safety, PK and Efficacy of AI-061 in Advanced Solid Tumors NCT05858736 | OncoC4, Inc. | Phase 1 |
| Recruiting | Developing Artificial Intelligence-based Algorism to Predict Side Effects and Symptoms From Chemotherapy NCT05937477 | Sehhoon Park | — |
| Terminated | 89Zr-girentuximab for PET Imaging of CAIX Positive Solid Tumors NCT05563272 | Telix Pharmaceuticals (Innovations) Pty Ltd | Phase 2 |
| Recruiting | CA-4948 in Combination With FOLFOX/PD-1 Inhibitor +/- Trastuzumab for Untreated Unresectable Gastric and Esoph NCT05187182 | Washington University School of Medicine | Phase 1 |
| Enrolling By Invitation | Study to Evaluate EnteroTracker® as a Sampling Method to Screen for Barrett's Esophagus/Esophageal Cancer NCT05706025 | University of Colorado, Denver | N/A |
| Active Not Recruiting | A Study of SNS-101 (Anti VISTA) Monotherapy and in Combination With Cemiplimab in Patients With Advanced Solid NCT05864144 | Sensei Biotherapeutics, Inc. | Phase 1 / Phase 2 |
| Not Yet Recruiting | Bone Microstructure by Using HR-pQCT After Esophagectomy NCT05812235 | Nagasaki University | — |
| Unknown | Utidelone and Anlotinib in Advanced Recurrent Metastatic Esophageal Cancer NCT05866510 | Peking University | Phase 2 |
| Completed | A Study of CDX-585 in Patients With Advanced Malignancies NCT05788484 | Celldex Therapeutics | Phase 1 |
| Recruiting | Influence Mechanism of Tumor Microenvironment Changes on Neoadjuvant Therapy for Esophageal Squamous Cell Carc NCT05894369 | Renmin Hospital of Wuhan University | — |
| Recruiting | The Effect of Chronic Stress on Efficacy of ICIs in Esophageal Cancer Patients (STRESS-ESCA Study) NCT05967910 | Second Xiangya Hospital of Central South University | — |
| Withdrawn | GI Organ Tracking Via Balloon Applicators NCT05471401 | Washington University School of Medicine | N/A |
| Terminated | Drainless Robot-assisted Minimally Invasive Esophagectomy NCT05553795 | Technische Universität Dresden | N/A |
| Active Not Recruiting | Claudin 18.2-Targeted Chimeric Antigen Receptor T-cells in Subjects With Unresectable, Locally Advanced, or Me NCT05539430 | Legend Biotech USA Inc | Phase 1 |
| Completed | A Liquid Biopsy for High-risk Pre-cancer Screening of Esophageal Adenocarcinoma NCT06381583 | City of Hope Medical Center | — |
| Completed | Quantitative Fluorescence Endoscopy Using Durvalumab-680LT in Esophageal Cancer NCT05450484 | University Medical Center Groningen | Phase 1 |
| Terminated | Transnasal Esophagoscopy (TNE) Esophageal Cancer Screening NCT05480891 | University of Illinois at Chicago | — |
| Completed | The Diagnostic Value of Nitrogen Element (N) in Esophagus Cancer NCT05494359 | Hepatopancreatobiliary Surgery Institute of Gansu Province | — |
| Recruiting | Efficacy and Safety of Penpulimab Combined With Anlotinib and Chemotherapy NCT06586242 | Xijing Hospital | Phase 2 |
| Unknown | High Flow Nasal Cannula After Esophagectomy NCT05718284 | Cristian Deana | N/A |
| Unknown | Utility and Usability of ActivSight™ Laser Speckle Imaging in Visualization of Tissue Perfusion and Blood Flow NCT05591053 | Activ Surgical | N/A |
| Recruiting | Liquid Biopsies in Esophageal Cancer NCT05704530 | Universitaire Ziekenhuizen KU Leuven | N/A |
| Unknown | A Clinical Study on Oncolytic Virus Injection (R130 OV) for the Treatment of Relapsed/Refractory Head and Neck NCT05830240 | Shanghai Yunying Medical Technology | EARLY_Phase 1 |
| Recruiting | Nimotuzumab Combined With Sintilimab and Chemotherapy for Advanced Esophageal Squamous Cell Carcinoma NCT06718205 | The First Affiliated Hospital of Zhengzhou University | Phase 2 |
| Unknown | A Clinical Trial of KVA12123 Treatment Alone and in Combination With Pembrolizumab In Advanced Solid Tumors (V NCT05708950 | Kineta Inc. | Phase 1 / Phase 2 |
| Active Not Recruiting | Organ-Preserving Endoscopic Resection & Adjuvant RADIO-immuno-chemotherapy for Esophageal Cancer NCT05667298 | University of Manitoba | Phase 1 |
| Recruiting | Nimotuzumab Concurrent With Chemoradiotherapy for Esophageal Cancer Patients NCT06429839 | Cancer Institute and Hospital, Chinese Academy of Medical Sciences | Phase 2 |
| Recruiting | Nimotuzumab Concurrent With Chemoradiotherapy for Patients With Unresectable Esophageal Squamous Cell Carcinom NCT06410651 | Cancer Institute and Hospital, Chinese Academy of Medical Sciences | Phase 2 |
| Recruiting | Rehabilitation and Recovery for Persons with Esophageal or Gastric Cancer NCT05698992 | Region Skane | — |
| Completed | The Role of Surgery for Esophageal Cancer With Metastatic Disease (M1) NCT06424210 | National Taiwan University Hospital | — |
| Recruiting | Investigating the Biomarkers in Tumor and Peripheral Blood to Evaluate the Efficacy of Cancer Immunotherapy in NCT06790797 | Zhao Jun | — |
| Unknown | Investigating the Biomarkers in Tumor and Peripheral Blood to Evaluate the Efficacy of Cancer Immunotherapy in NCT05789498 | Zhao Jun | — |
| Recruiting | A Study Involving Neoadjuvant Chemoradiotherapy with Hypofractionated Radiotherapy in Patients with Esophageal NCT05370144 | AHS Cancer Control Alberta | N/A |
| Recruiting | Deep-sea Fish Oil for Prevention of Acute Radiation-induced Esophagitis NCT06392971 | First Affiliated Hospital of Chengdu Medical College | Phase 2 |
| Unknown | Clinical Efficacy and Safety of Endoscopic Dilatation With Eso-Filp in Benign Esophageal Strictures NCT05725473 | Istituto Clinico Humanitas | N/A |
| Active Not Recruiting | Oral Axl/Mer/CSF1R Selective Tyrosine Kinase Inhibitor Q702 in Combination With Pembrolizumab in Patients With NCT05438420 | Qurient Co., Ltd. | Phase 1 / Phase 2 |
| Recruiting | Radiotherapy Combined With Immunochemotherapy in Metastatic Esophageal Squamous Cell Carcinoma NCT05978193 | Shanghai Chest Hospital | Phase 2 |
| Not Yet Recruiting | EMR Versus ESD for Barrett's Neoplasia NCT05276791 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | N/A |
| Unknown | Assessment of Minimally Invasive Surgery for Esophageal Cancer NCT05662644 | Sohag University | N/A |
| Terminated | Oral AMXT 1501 Dicaprate in Combination With IV DFMO NCT05500508 | Aminex Therapeutics, Inc. | Phase 1 / Phase 2 |
| Active Not Recruiting | Study of the Monoclonal Antibody IMT-009 in Patients With Advanced Solid Tumors or Lymphomas NCT05565417 | Immunitas Therapeutics | Phase 1 / Phase 2 |
| Terminated | Systems Biology of Gastrointestinal and Related Diseases NCT05579444 | Viome | — |
| Unknown | The PET-CT Predicting Response to Immunochemotherapy in Esophageal Cancer NCT05615103 | Guangdong Provincial People's Hospital | — |
| Recruiting | Nutritional Support During Induction Therapy for Esophageal Cancer NCT05314946 | Mehdi Qiabi | N/A |
| Recruiting | PD-1 Inhibitor Combined With Neoadjuvant Chemoradiotherapy Plus Surgery for Locally Advanced ESCC (NEOCRTEC210 NCT05357846 | Sun Yat-sen University | Phase 3 |
| Recruiting | A Study to Evaluate the Safety, Pharmacokinetics, and Activity of Enzelkitug as a Single Agent and in Combinat NCT05581004 | Genentech, Inc. | Phase 1 |
| Recruiting | Perioperative Analgesia Modes in Minimally Invasive Esophagectomy NCT05504265 | Cancer Institute and Hospital, Chinese Academy of Medical Sciences | Phase 2 / Phase 3 |
| Active Not Recruiting | A Safety, Tolerability and Efficacy Study of NC410 Plus Pembrolizumab in Participants with Advanced Unresectab NCT05572684 | NextCure, Inc. | Phase 1 / Phase 2 |
| Unknown | Evaluating Acid Reflux After Oesophageal Stenting Using Anti-reflux Stents NCT05303298 | University of Cape Town | N/A |
| Completed | Study on the Design and Application of Special Semi Recumbent Cushion for Postoperative Patients With Esophage NCT05542680 | Cancer Institute and Hospital, Chinese Academy of Medical Sciences | N/A |
| Completed | Clinical Validation of AI-Assisted Radiotherapy Contouring Software for Thoracic Organs at Risk NCT05787522 | Tianjin Medical University Cancer Institute and Hospital | — |
| Active Not Recruiting | Nivolumab During Active Surveillance After Neoadjuvant Chemoradiation for Esophageal Cancer: SANO-3 Study NCT05491616 | Erasmus Medical Center | Phase 2 |
| Recruiting | The Efficacy of Neoadjuvant Chemoradiotherapy in Comparison With Neoadjuvant Chemotherapy in Patients With Res NCT05547529 | Blokhin's Russian Cancer Research Center | Phase 3 |
| Suspended | Natural Killer (NK) Cells in Combination With Interleukin-2 (IL-2) and Transforming Growth Factor Beta (TGFbet NCT05400122 | David Wald | Phase 1 |
| Recruiting | Raman Spectroscopy-Based Deep Learning Model for Early Pan-Cancer Early Diagnosis NCT06822413 | Second Affiliated Hospital, School of Medicine, Zhejiang University | — |
| Unknown | Computational Prediction and Experimental Validation of Esophageal Cancer Associated Neoantigens NCT05498168 | University Medical Center Ho Chi Minh City (UMC) | — |
| Completed | Nasal Mask Kit in Gastrointestinal Endoscopy NCT05405530 | RenJi Hospital | N/A |
| Completed | Mechanical Bowel Preparation Versus no Bowel Preparation for Esophageal Cancer Surgery NCT05523960 | Cancer Institute and Hospital, Chinese Academy of Medical Sciences | N/A |
| Completed | Methylation Biomarkers for Pioneering Early Esophageal Cancer Detection NCT06895551 | Singlera Genomics Inc. | — |
| Recruiting | Value of Pleural Lavage Cytology in Resectable Esophageal Carcinoma Eastern Cooperative Thoracic Oncology Proj NCT05443841 | Fudan University | — |
| Terminated | FAPi Radioligand OpeN-Label, Phase 1 Study to Evaluate Safety, Tolerability and DosImetry of [Lu-177]-PNT6555; NCT05432193 | POINT Biopharma, a wholly owned subsidiary of Eli Lilly and Company | Phase 1 |
| Unknown | Project CADENCE (CAncer Detected Early caN be CurEd) NCT05633342 | MiRXES Pte Ltd | — |
| Completed | Afuresertib +Sintilimab+Chemotherapy in Patients With Selected Solid Tumors That Resistance to Prior Anti-PD-1 NCT05383482 | Laekna Limited | Phase 1 / Phase 2 |
| Unknown | Toripalimab Plus Radiotherapy for Elderly Esophageal Cancer Patients Treated With Non-chemotherapy Strategy NCT05817201 | Taizhou Hospital | Phase 2 / Phase 3 |
| Recruiting | Pre- and Post-operative TEG Indices in Patients With or Without Adenocarcinoma Undergoing Surgical Resection NCT05517811 | University of Colorado, Denver | — |
| Unknown | Safety and Efficacy of CEA-targeted CAR-T for CEA-positive Advanced Malignant Solid Tumors NCT05538195 | Chongqing Precision Biotech Co., Ltd | Phase 1 / Phase 2 |
| Unknown | To Evaluate OBI-833/OBI-821 in Patients With Locally Advanced, Globo H-Positive Esophageal Cancer for Recurren NCT05376423 | National Taiwan University Hospital | Phase 2 |
| Recruiting | The Level of Patient Participation in Lung and Esophageal Cancer Patients Treated With Definitive Radiochemoth NCT06019455 | Sun Yat-sen University | — |
| Completed | A Clinical Study of CEA-targeted CAR-T in the Treatment of CEA-positive Advanced Malignant Solid Tumors NCT05396300 | Weijia Fang, MD | Phase 1 |
| Unknown | Study of NGM438 as Monotherapy and in Combination With Pembrolizumab in Advanced or Metastatic Solid Tumors NCT05311618 | NGM Biopharmaceuticals, Inc | Phase 1 |
| Recruiting | cfDNA Assay Prospective Observational Validation for Early Cancer Detection and Minimal Residual Disease NCT05366881 | Adela, Inc | — |
| Unknown | Comparison of Subtotal Stomach and Narrow Gastric Tube After Esophagectomy NCT05342805 | University Medical Center Ho Chi Minh City (UMC) | N/A |
| Recruiting | PROton Versus Photon Therapy for Esophageal Cancer - a Trimodality Strategy NCT05055648 | University of Aarhus | Phase 3 |
| Completed | Clinical Value and Efficacy Index of Lymphadenectomy for Thoracic Escc NCT05604664 | Yongtao Han | — |
| Completed | The Impact of Two-field or Three-field Lymphadenectomy on Overall Survival in Middle and Lower Thoracic Esopha NCT05617352 | Yongtao Han | — |
| Terminated | NIF-Guided RAMIE Using ICG Versus OTE Feasibility RCT NCT04938973 | St. Joseph's Healthcare Hamilton | N/A |
| Unknown | Risk Factors of Relapse in Esophageal Squamous Cell Cancers Who Achieve PCR to Neoadjuvant Chemoradiotherapy NCT06061263 | Sun Yat-sen University | — |
| Unknown | Adjuvant Radiotherapy for Patients With Esophageal Squamous Cell Carcinoma After R0 Resection NCT05460403 | Chinese Academy of Medical Sciences | — |
| Terminated | A Study of TAK-500 With or Without Pembrolizumab in Adults With Select Locally Advanced or Metastatic Solid Tu NCT05070247 | Takeda | Phase 1 / Phase 2 |
| Recruiting | The Thoracic Peri-Operative Integrative Surgical Care Evaluation Trial - Stage III NCT04871412 | Ottawa Hospital Research Institute | Phase 3 |
| Withdrawn | ChemoRadiation And Tislelizumab for Esophageal/EGJ Cancer NCT05245760 | Zhonglin Hao | Phase 2 |
| Active Not Recruiting | Study of NGM831 as Monotherapy and in Combination With Pembrolizumab or Pembrolizumab and NGM438 in Advanced o NCT05215574 | NGM Biopharmaceuticals, Inc | Phase 1 |
| Active Not Recruiting | To Observe the Benefit of Adding Brachytherapy After CCRT on Resectable Esophageal Cancer Patients Without Sur NCT05145647 | Chang Gung Memorial Hospital | N/A |
| Completed | Intestinal Microbiome, Oral Microbiome, and Whole Blood Transcriptome Analyses in Gastrointestinal Malignancie NCT05462314 | Viome | — |
| Unknown | Safety and Efficacy of Personalized Neoantigen Vaccine in Advanced Gastric Cancer, Esophageal Cancer and Liver NCT05192460 | jianming xu | N/A |
| Recruiting | Pharmacokinetic Study of Skeletal Muscle Area-based Paclitaxel Infusion in Patients With Cancer NCT05183126 | University of Michigan Rogel Cancer Center | Phase 4 |
| Terminated | Niraparib in the Treatment of Patients With Advanced PALB2 Mutated Tumors NCT05169437 | Tempus AI | Phase 2 |
| Unknown | Investigating the Association Between Microbiota and Esophageal/Oropharyngeal Cancer NCT05412628 | National Cheng-Kung University Hospital | N/A |
| Recruiting | TRAstuzumab and Pertuzumab for HER2+ Resectable Oesophageal Cancer NCT05188313 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | Phase 3 |
| Unknown | Non-endoscopic Esophageal Sampling to Detect Barrett's Esophagus and Esophageal Cancer in Veterans NCT05210049 | Louis Stokes VA Medical Center | N/A |
| Unknown | Visualization Versus Intraoperative Neuromonitoring of the Recurrent Laryngeal Nerves During Thoracoscopic Eso NCT05199168 | Tianjin Medical University Cancer Institute and Hospital | N/A |
| Completed | Effects of Oral Aloe Vera Juice on Chemotherapy and Radiation-induced Oral Mucositis and Esophagitis NCT05369234 | Covenant Health Cancer Center | Phase 3 |
| Recruiting | Resilience and Equity in Aging, Cancer, and Health (REACH) NCT04674267 | Dana-Farber Cancer Institute | N/A |
| Suspended | AN0025 and Chemoradiotherapy Combination in Esophageal Cancer NCT05191667 | Adlai Nortye Biopharma Co., Ltd. | Phase 1 |
| Recruiting | A Study of Perioperative Camrelizumab Combined With Chemotherapy in Patients With Resectable ESCC NCT05182944 | The First Affiliated Hospital of Zhengzhou University | Phase 2 |
| Active Not Recruiting | A Study on the Impact of Intelligent Nutrition Management on Clinical Outcomes in Chemotherapy Patients With G NCT06997302 | Tianjin Medical University Cancer Institute and Hospital | N/A |
| Unknown | Study of First-line Camrelizumab With or Without Chemotherapy for Advanced Esophageal Squamous Cell Cancer NCT04654403 | The First Affiliated Hospital of Zhengzhou University | N/A |
| Unknown | A Multicenter, Randomized Controlled, Phase II Clinical Study of First-line Chemotherapy and Camrelizumab With NCT05183958 | Zhejiang Cancer Hospital | Phase 2 |
| Unknown | Assessment of Graft Perfusion and Oxygenation for Improved Outcome in Esophageal Cancer Surgery NCT03587532 | University Hospital, Ghent | N/A |
| Recruiting | A Trial of Palliative Chemotherapy, Radiation and Immune Treatment for Oesophageal Cancer: PALEO Study NCT06290505 | Australasian Gastro-Intestinal Trials Group | Phase 2 |
| Unknown | Study of Anti-PD-1 Antibody SHR-1210 Plus Apatinib vs SHR-1210 as Second-Line Treatment of Advanced Esophageal NCT05049681 | Feng Wang | Phase 3 |
| Unknown | Camrelizumab Combined With CRT for Treatment of Patients With Local Recurrence of Esophageal Cancer NCT04390945 | The First Affiliated Hospital of Henan University of Science and Technology | Phase 2 |
| Unknown | VITAMin Insufficiency in Esophagogastric Neoplasms NCT05281380 | Zuyderland Medisch Centrum | N/A |
| Not Yet Recruiting | Clinical Study on the Efficacy of Single-port Inflatable Mediastinoscopy Combined With Laparoscopic-assisted S NCT05105945 | Fifth Affiliated Hospital, Sun Yat-Sen University | N/A |
| Recruiting | Triplex Checkpoint Inhibitors Therapy for Advanced Solid Tumors NCT05187338 | Second Affiliated Hospital of Guangzhou Medical University | Phase 1 / Phase 2 |
| Recruiting | Hypoxia Imaging for Esophageal Cancer to Guide Personalized Radiation Therapy NCT04846309 | University of Utah | Phase 1 |
| Active Not Recruiting | The Registry Study of Genetic Alterations of Esophageal Cancer in Taiwan NCT04996095 | National Health Research Institutes, Taiwan | — |
| Terminated | ADP-A2M4CD8 in HLA-A2+ Subjects With MAGE-A4 Positive Esophageal or Esophagogastric Junction Cancers (SURPASS- NCT04752358 | Adaptimmune | Phase 2 |
| Unknown | Clinical Study of CEA-targeted CAR-T Therapy for CEA-positive Advanced Malignant Solid Tumors NCT05415475 | Chongqing Precision Biotech Co., Ltd | Phase 1 |
| Completed | Capnographic Monitoring in Gastrointestinal Endoscopy for Elderly Patients NCT05030870 | RenJi Hospital | N/A |
| Recruiting | A Beta-only IL-2 ImmunoTherapY Study NCT05086692 | Medicenna Therapeutics, Inc. | Phase 1 / Phase 2 |
| Completed | A Study of PRT1419 in Patients With Advanced Solid Tumors NCT04837677 | Prelude Therapeutics | Phase 1 |
| Unknown | Anlotinib Combined With PD-1 Inhibitors for Advanced/Metastatic Esophageal Cancer NCT04984096 | Shanghai Chest Hospital | — |
| Completed | Migration Rates of Sutured vs Non-sutured Esophageal Stent Placement NCT05082948 | West Virginia University | N/A |
| Unknown | Anlotinib for Esophageal Cancer (AFEC) NCT04966611 | Anyang Tumor Hospital | — |
| Completed | Second-line Cabozantinib and Atezolizumab in Patients With Recurrent or Metastatic Esophageal Squamous Cell Ca NCT05007613 | National Taiwan University Hospital | Phase 2 |
| Completed | Octreotide Treatment to Improve Nutritional Recovery After Surgery for Patients with Esophageal or Gastric Can NCT04871204 | Fredrik Klevebro | Phase 2 |