NCT05504265

Perioperative Analgesia Modes in Minimally Invasive Esophagectomy

Comparison of Efficacy and Safety of Different Analgesic Modes in Minimally Invasive Esophagectomy for Esophageal Cancer

• Status: Recruiting
• Phase: Phase 2 / Phase 3
• Study type: Interventional
• Enrollment: 102 (estimated)
• Sponsor: Cancer Institute and Hospital, Chinese Academy of Medical Sciences · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

This study was designed to compare analgesic efficacy and safety of different perioperative analgesic modes in minimally invasive esophagectomy for esophageal cancer.

Conditions

• Esophageal Cancer
• Perioperative Analgesia
• NSAIDs
• Opioid
• Patient-controlled Analgesia

Interventions

Type	Name	Description
DRUG	Preemptive flurbiprofen axetil	50mg once，30min before induction anesthesia
DRUG	Postoperative flurbiprofen axetil	50mg bid
DEVICE	Patient-controlled analgesia pump	Sufentanil 2.5 μg/kg+ondansetron 8mg, prepared to 100ml normal saline; background dose: 2 ml/h, single press analgesic pump injection volume: 0.5 ml, locking time: 15 min.

Timeline

• Start date: 2022-10-10
• Primary completion: 2025-09-30
• Completion: 2025-12-20
• First posted: 2022-08-17
• Last updated: 2025-03-20

Locations

1 site across 1 country: China