NCT07519655

Phase 1 Study of PF-08046033 in Advanced Solid Tumors

A Phase 1 Study to Investigate PF-08046033 in Participants With Advanced Solid Tumors

• Status: Not Yet Recruiting
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 250 (estimated)
• Sponsor: Pfizer · Industry
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This is an early-stage (Phase 1) clinical study testing a new study medicine called PF-08046033. The goal of the study is to understand how safe the medicine is, how well people tolerate it, how it behaves in the body, and whether it shows early signs of helping to treat cancer. The study includes adult participants who have advanced cancers that cannot be removed by surgery or have spread to other parts of the body. These cancers include non-small cell lung cancer, esophageal squamous cell cancer, and melanoma. The study has two parts: In the first part, small groups of participants receive increasing doses of the study medicine. This helps researchers find a dose that is safe and suitable for further testing. Once a suitable dose is identified, the second part enrolls more participants with specific cancer types to better understand the safety of the medicine and whether it shows signs of helping control the cancer. Participants receive the study medicine through regular treatment cycles and are closely monitored for side effects and how their cancer responds. The information from this study will help researchers decide whether PF-08046033 should be studied further in later-stage clinical trials.

Conditions

• Non-Small-Cell Lung
• Esophageal Cancer
• Cutaneous Melanoma

Interventions

Type	Name	Description
DRUG	PF-08046033	Powder for solution for infusion.

Timeline

• Start date: 2026-04-01
• Primary completion: 2028-07-14
• Completion: 2029-07-14
• First posted: 2026-04-09
• Last updated: 2026-04-09

Locations

2 sites across 1 country: Puerto Rico

Regulatory

• FDA-regulated drug study