NCT06346054

Molecular Assessment for Gastro-Esophageal Cancer

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 1,000 (estimated)
• Sponsor: KU Leuven · Academic / Other
• Sex: All
• Age: 18 Years – 100 Years
• Healthy volunteers: Accepted

Summary

The goal of this minimally invasive interventional study is to learn if oncometabolic biomarkers, detected in the exhaled breath and blood can identify early-stage gastro-oesophageal cancer in patient at risk for gastro-oesophageal cancer. The main questions this study aims to answer: Are oncometabolites proficient and reproducible enough to function as diagnostic biomarkers? Can these biomarkers identify early-stage gastro-esophageal cancer? Researchers will compare participants with gastro-oesophageal cancer to healthy controls and participants with Barrett's esophagus to detect meaningful differences between the groups. Participants will provide a breath and blood sample during their routine standard of care visits.

Conditions

• Esophageal Cancer
• Gastric Cancer
• Barrett Esophagus

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Breath analysis	Detection of proteins and volatile organic compounds (oncometabolites) in the exhaled breath
DIAGNOSTIC_TEST	Blood analysis	Detection of proteins and circulating tumor DNA (oncometabolites) in the peripheral blood

Timeline

• Start date: 2024-08-01
• Primary completion: 2029-07-01
• Completion: 2029-07-01
• First posted: 2024-04-03
• Last updated: 2026-02-17

Locations

1 site across 1 country: Belgium