| Not Yet Recruiting | Itraconazole in Combination With Ablation for the Prevention of Esophageal Cancer in Patients With High-risk B NCT06732388 | National Cancer Institute (NCI) | Phase 2 |
| Not Yet Recruiting | Minimally Invasive Approaches for the Diagnosis of Barrett's Esophagus and Esophageal Cancer, SOS5C Trial NCT07206589 | Mayo Clinic | N/A |
| Not Yet Recruiting | A Study of Barrett's Esophagus Patients: Optimization of a Risk Model to Better Predict the Development of Can NCT07455422 | University Hospital, Antwerp | N/A |
| Enrolling By Invitation | Minimally Invasive Molecular Approaches for the Detection of Barrett's Esophagus- High Grade Dysplasia and Eso NCT07212491 | Mayo Clinic | — |
| Recruiting | Impact of RFA on Esophageal Distensibility and Mucosal Impedance NCT07126535 | Mayo Clinic | — |
| Recruiting | Nonendoscopic Screening for Barrett's Esophagus in Veterans Without Chronic Reflux NCT06746623 | Louis Stokes VA Medical Center | N/A |
| Not Yet Recruiting | Barrett's Esophagus in Patients with GERD NCT06897540 | Assiut University | N/A |
| Recruiting | Multi-Site Detection of Barrett's Esophagus in Patients Without Chronic GERD Symptoms NCT06687603 | Case Comprehensive Cancer Center | N/A |
| Recruiting | "Less-is-more in Barrett-surveillance" Care Evaluation of Barrett's Patients With Low-Risk in Whom Endoscopic NCT06803147 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | — |
| Recruiting | Non-Endoscopic Detection of Barrett's Esophagus Using Methylation Biomarkers on EndoSign® Cell Collection Devi NCT06803927 | Cyted Health Inc | — |
| Recruiting | Ultralong-segment Barrett's Esophagus: Towards a Capsule-sponge Surveillance Strategy NCT06720636 | Erasmus Medical Center | N/A |
| Withdrawn | Imaging of the Esophagus Using a SECM Capsule NCT03546660 | Massachusetts General Hospital | N/A |
| Recruiting | Barrett's Esophagitis in Anorexia Nervosa Binge/Purge Subtype NCT06532734 | Denver Health and Hospital Authority | — |
| Recruiting | Patient Preferences for Barrett's Esophagus and Esophageal Cancer Screening Tests NCT06693622 | University of Colorado, Denver | — |
| Recruiting | Molecular Assessment for Gastro-Esophageal Cancer NCT06346054 | KU Leuven | N/A |
| Unknown | Safety and Feasibility of Immuno-OCT NCT06008522 | University Medical Center Groningen | N/A |
| Recruiting | Obeticholic Acid for Prevention in Barrett's Esophagus NCT04939051 | National Cancer Institute (NCI) | Phase 2 |
| Completed | Introduction of EndoSign ® in Management of Barrett's Oesophagus - a Swedish Feasibility Study NCT07036432 | Vastra Gotaland Region | N/A |
| Active Not Recruiting | Trans-Oral Sampling as an Alternative Surveillance of Barrett's Esophagus Pilot NCT07490340 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | — |
| Recruiting | Assessment of a Minimally Invasive Collection Device for Molecular Analysis of Esophageal Samples NCT06071845 | Mayo Clinic | N/A |
| Completed | Raman Probe for In-vivo Diagnostics (During Oesophageal) Endoscopy NCT03468634 | University of Exeter | N/A |
| Enrolling By Invitation | Study to Evaluate EnteroTracker® as a Sampling Method to Screen for Barrett's Esophagus/Esophageal Cancer NCT05706025 | University of Colorado, Denver | N/A |
| Recruiting | InAdvance: Surveillance, Prevention, and Interception in a Population at Risk for Cancer NCT05463796 | Dana-Farber Cancer Institute | — |
| Completed | A Liquid Biopsy for High-risk Pre-cancer Screening of Esophageal Adenocarcinoma NCT06381583 | City of Hope Medical Center | — |
| Completed | Clinical Utility of a Non Endoscopic Device EsoCheck and Biomarker EsoGuard as Alternative to Endoscopy for Sc NCT05778851 | Lucid Diagnostics, Inc. | N/A |
| Unknown | Lucid Registry Study NCT05965999 | Lucid Diagnostics, Inc. | — |
| Enrolling By Invitation | Biomarkers of Airway Disease, Barrett's and Underdiagnosed Reflux Noninvasively (BADBURN) NCT05216133 | NYU Langone Health | — |
| Completed | CLUE: CLinical Utility Study of EsoGuard NCT06030180 | Lucid Diagnostics, Inc. | N/A |
| Unknown | Public's Intended Uptake and Views on Organization of Esophageal Cancer Screening NCT05690958 | Radboud University Medical Center | — |
| Recruiting | Surveillance vs. Endoscopic Therapy for Barrett's Esophagus With Low-grade Dysplasia NCT05753748 | University of Colorado, Denver | N/A |
| Enrolling By Invitation | C2 CryoBalloon™ 180 Ablation System Dose De-escalation Study. NCT03311451 | Pentax Medical | N/A |
| Completed | GCC Agonist Signal in the Small Intestine NCT05107219 | University of Wisconsin, Madison | Phase 1 |
| Terminated | Systems Biology of Gastrointestinal and Related Diseases NCT05579444 | Viome | — |
| Recruiting | A Multicenter Prospective Cohort Study Comparing Random Biopsies Versus Wide-Area Transepithelial Brush-Sampli NCT05642338 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | — |
| Recruiting | Seattle Biopsy Protocol Versus Wide-Area Transepithelial Sampling in Patients With Barrett's Esophagus Undergo NCT05530343 | University of Colorado, Denver | N/A |
| Unknown | Early Detection of Cancer Onset Based on Sensing Field Cancerization at the Organ Level in the Alimentary Trac NCT05247346 | University Medical Center Groningen | N/A |
| Completed | Real-time Computer Aided Detection of Barrett's Neoplasia NCT05628441 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | — |
| Completed | High Resolution Virtual Chromoendoscopy Versus Seattle Protocol for the Surveillance of Barrett's Esophagus NCT05229783 | Nantes University Hospital | N/A |
| Recruiting | A Study Comparing the Effectiveness of EndoRotor Versus Radiofrequency in Treating Barrett's Esophagus NCT04867590 | University Hospital, Angers | N/A |
| Unknown | Non-endoscopic Esophageal Sampling to Detect Barrett's Esophagus and Esophageal Cancer in Veterans NCT05210049 | Louis Stokes VA Medical Center | N/A |
| Recruiting | Endoscopic Submucosal Dissection (ESD) NCT05468008 | AdventHealth | — |
| Completed | Endoscopic Radiofrequency Ablation Versus Hybrid Argon Plasma Coagulation in the Treatment of Barrett's Esopha NCT05051475 | Centre of Postgraduate Medical Education | N/A |
| Recruiting | Minimally Invasive Molecular Approaches for the Diagnosis of Barrett's Esophagus and Esophageal Adenocarcinoma NCT03961945 | Mayo Clinic | N/A |
| Active Not Recruiting | Endoscopic Biopsy Techniques in Barrett's Esophagus Patients NCT05578677 | St. Antonius Hospital | N/A |
| Completed | Clinical Utility Evidence for TissueCypher® NCT05200325 | Qure Healthcare, LLC | N/A |
| Unknown | Diagnostic Performance Indicators in Upper GI Endoscopy:PROSPERO Study NCT04843397 | University of Cambridge | — |
| Completed | Early Detection of Barrett's Esophagus in Participants With Reflux Symptoms in Primary Care NCT04656392 | Radboud University Medical Center | N/A |
| Recruiting | Longitudinal Oral Microbiome Sampling for BE NCT05133102 | Columbia University | — |
| Completed | The Microbiome, Bile Acids, and Notch in Barrett's Esophagus (BE) NCT05524844 | Columbia University | — |
| Unknown | Clinical Utility of Methylation-based Prognostic Assay for Barrett's Esophagus NCT05846971 | Capsulomics, Inc. | N/A |
| Completed | a/LCI-OCT Pilot in Esophagus NCT04392167 | Duke University | N/A |
| Recruiting | Wide-Area Transepithelial Sampling in Endoscopic Eradication Therapy for Barrett's Esophagus NCT05056051 | Northwestern University | N/A |
| Terminated | Nitrates and IL-8 in Barrett's Esophagus NCT04642690 | Mayo Clinic | — |
| Completed | Patient Acceptance and Preference Among Screening Modalities for Detection of Barrett's Esophagus NCT04301986 | University of North Carolina, Chapel Hill | N/A |
| Unknown | Early Detection of Barrett's Esophagus Through Deep Image Retrieval NCT04478929 | Leigh Taylor | — |
| Unknown | PPI Therapy Impact on GERD After Sleeve Gastrectomy NCT04400136 | University of Roma La Sapienza | EARLY_Phase 1 |
| Unknown | Efficacy of EsoGuard Assay on Esophageal Surface Cells Collected With EsoCheck vs EGD for the Diagnosis of BE NCT04295811 | Lucid Diagnostics, Inc. | N/A |
| Recruiting | Clinical Utility of WATS3D: A 5-Year Prospective Study NCT04312633 | CDx Diagnostics | — |
| Withdrawn | Barretts oEsophageal Resection With Steroid Therapy Trial NCT02004782 | Professor Michael Bourke | Phase 4 |
| Completed | Efficacy of EsoGuard on Samples Collected Using EsoCheck Versus EGD for the Diagnosis of BE NCT04293458 | Lucid Diagnostics, Inc. | N/A |
| Unknown | Outcomes of Endoscopically Resected High-risk Mucosal and Low- and High-risk Submucosal Adenocarcinoma Arising NCT04818476 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | — |
| Unknown | Classification of Adenocarcinoma of the Esophagogastric Junction NCT04151524 | St. James's Hospital, Ireland | — |
| Unknown | Non-invasive Testing for Early oEesophageal Cancer and Dysplasia NCT04001478 | Imperial College London | — |
| Unknown | Detection of Early Esophageal Cancer by NIR-FME. NCT03877601 | University Medical Center Groningen | Phase 2 |
| Terminated | Phase 1B Study of KSP/QRH Dimer for Detection of Neoplasia in the Esophagus NCT03852576 | University of Michigan | Phase 1 |
| Enrolling By Invitation | The Johns Hopkins Heartburn Center Registry NCT03853772 | Johns Hopkins University | — |
| Unknown | Non-magnified NBI in Barrett's Oesophagus Neoplasia Detection and Delineation NCT04621474 | University of Cambridge | — |
| Completed | Linked Color Imaging vs White Light Imaging for Detection of Gastric Cancer Precursors NCT03990025 | Changi General Hospital | N/A |
| Enrolling By Invitation | Evaluation of Tethered Capsule Endomicroscopy as a Screening Tool for Barrett's Esophagus in the Primary Care NCT04561791 | Massachusetts General Hospital | N/A |
| Completed | OCT Pilot in Esophagus NCT03434834 | Duke University | N/A |
| Active Not Recruiting | Nitrous Oxide For Endoscopic Ablation of Refractory Barrett's Esophagus (NO FEAR-BE) NCT03554356 | University of North Carolina, Chapel Hill | N/A |
| Withdrawn | Predict Recurrence of Barrett's Esophagus After Complete Eradication of Intestinal Metaplasia NCT03670134 | Mayo Clinic | N/A |
| Terminated | Rapid Assessment of Esophageal Adenocarcinoma Risk Test NCT03366012 | Columbia University | N/A |
| Enrolling By Invitation | Outcomes After Transoral Incisionless Fundoplication (TIF) Following Successful Endoscopic Ablation for Barret NCT04457193 | Johns Hopkins University | — |
| Unknown | The Bacterial Composition of the Stomach in Reflux Disease NCT03835663 | Imperial College London | — |
| Completed | Study of Multiplexed Heptapeptides for Detection of Neoplasia in the Esophagus NCT03589443 | University of Michigan | Phase 1 |
| Unknown | Gluten Related Disorders in Barrett's Esophagus NCT03329534 | McMaster University | N/A |
| Unknown | Radiofrequency Ablation vs Sham Procedure for Symptomatic Cervical Inlet Patch NCT03471052 | Guy's and St Thomas' NHS Foundation Trust | N/A |
| Completed | The Microenvironment in Barrett's Esophagus NCT03060642 | Columbia University | — |
| Completed | Feasibility of Multi-Spectral Endoscopic Imaging for Detection of Early Neoplasia in Barrett's Oesophagus NCT03388047 | University of Cambridge | N/A |
| Terminated | Cap Assisted Upper Endoscopy Versus High Definition White Light Endoscopy and Narrow Band Imaging Alone In The NCT03417570 | Washington University School of Medicine | N/A |
| Recruiting | Pilot Study for OCT Guided In Vivo Laser Capture Microdissection for Assessing the Prognosis of Barrett's Esop NCT03830801 | Massachusetts General Hospital | N/A |
| Completed | Balloon Cryotherapy vs. Radiofrequency Ablation Pain Study NCT03387982 | Geisinger Clinic | — |
| Completed | Impact of NBI on Patients Undergoing Endoscopic Eradication Therapy NCT03191604 | Northwestern University | — |
| Completed | Healing of the Esophageal Mucosa After RFA of Barrett's Esophagus NCT02688114 | Dallas VA Medical Center | N/A |
| Completed | The Evaluation of Patients With Esophageal and Foregut Disorders With WATS (Wide Area Transepithelial Sample W NCT03859557 | CDx Diagnostics | — |
| Completed | Wide Area Transepithelial Sample Esophageal Biopsy Combined With Computer Assisted 3-Dimensional Tissue Analys NCT03015389 | CDx Diagnostics | — |
| Completed | Histology Post-Endoscopic Eradication Therapy (EET) NCT03375060 | Northwestern University | — |
| Recruiting | Prospective Endoscopic Follow-up of Patients With Submucosal and High Risk Mucosal Esophageal Adenocarcinoma NCT03222635 | Amsterdam UMC | N/A |
| Unknown | Microbiome Involvement With Barrett's Esophagus and Progression to Esophageal Adenocarcinoma NCT03216135 | Ochsner Health System | — |
| Completed | Evaluation of Performance Characteristics of Capsule Endoscopy With PillCam UGI Capsule Compared to Standard E NCT03167970 | Midwest Biomedical Research Foundation | — |
| Unknown | Confocal Endomicroscopy for Permeability of Esophageal Wall in Refractory Gastroesophageal Reflux Disease (GER NCT03228407 | McGuire Research Institute | N/A |
| Active Not Recruiting | Coordinating Center: Natural History of Barrett's Esophagus Using Tethered Capsule Endomicroscopy NCT03459339 | Massachusetts General Hospital | N/A |
| Completed | Evaluation of Safety and Dose Response Using C2 CryoBalloon™ Swipe Ablation System for Barrett's Esophagus NCT03097666 | Pentax Medical | N/A |
| Completed | Molecular Fluorescence Endoscopy of (Pre)Malignant Esophageal Lesions NCT03205501 | University Medical Center Groningen | Phase 1 |
| Unknown | Neoplastic Barrett Esophagus: Endoscopic Piecemeal vs. En Bloc Resection NCT03427346 | Universitätsklinikum Hamburg-Eppendorf | N/A |
| Active Not Recruiting | Natural History of Barrett's Esophagus Using Tethered Capsule Endomicroscopy NCT02994693 | Massachusetts General Hospital | — |
| Completed | Swallowable Sponge Cell Sampling Device and Next Generation Sequencing in Detecting Esophageal Cancer in Patie NCT02890979 | OHSU Knight Cancer Institute | N/A |
| Completed | Tethered Capsule Endoscope in Screening Patients With Barrett Esophagus NCT02729948 | University of Washington | N/A |
| Terminated | The WATS3D (Wide Area Transepithelial Sample Biopsy With 3-Dimensional Computer-Assisted Analysis) U.S. Regist NCT02988934 | CDx Diagnostics | — |
| Active Not Recruiting | Multi-center Clinical Study to Evaluate the C2 CryoBalloon Focal Ablation System NCT02514525 | Pentax Medical | N/A |
| Completed | A Prospective Study Comparing the Accuracy of Olympus Lucera Spectrum Technology vs Olympus Lucera Elite Techn NCT03073226 | Portsmouth Hospitals NHS Trust | N/A |
| Terminated | TECR & ECM Placement for Esophageal High Grade Dysplasia NCT02396745 | Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) | N/A |
| Active Not Recruiting | Aspirin in Preventing Disease Recurrence in Patients With Barrett Esophagus After Successful Elimination by Ra NCT02521285 | National Cancer Institute (NCI) | Phase 2 |
| Recruiting | EsophaCap for the Detection of Early Esophageal Carcinoma NCT04214119 | Johns Hopkins University | — |
| Unknown | ESD for the Treatment of Early Barrett's Neoplasia NCT02583087 | Hôpital Cochin | — |
| Completed | A Minimally-Invasive Sponge on a String Device for Screening for Barrett's Esophagus NCT02560623 | Mayo Clinic | N/A |
| Unknown | Internet-based Perioperative Exercise Program in Patients With Barrett's Carcinoma Scheduled for Esophagectomy NCT02478996 | University of Leipzig | N/A |
| Completed | "Using Dilute Vinegar to Find Changes in Cells During Endoscopy for Patients With Barrett's Oesophagus" (The A NCT02407392 | Portsmouth Hospitals NHS Trust | N/A |
| Completed | Non-endoscopic Brushing of the Esophagus Using a Non-endoscopic Inflatable Balloon of the Esophagus in Screeni NCT02451124 | Case Comprehensive Cancer Center | N/A |
| Completed | An Evaluation of the Utility of the ExSpiron Respiratory Variation Monitor During Upper GI Endoscopy NCT02310230 | Donald Mathews | N/A |
| Completed | Early Detection of Tumors of the Digestive Tract by Confocal Endomicroscopy NCT02284802 | Fauze Maluf Filho | N/A |
| Completed | Photoacoustic Endoscopy of Barrett's Esophagus NCT02606292 | Washington University School of Medicine | EARLY_Phase 1 |
| Completed | Acid Pocket: Position and Aspiration NCT02199002 | KU Leuven | N/A |
| Completed | WATS3D for the Detection of Esophageal Dysplasia NCT03008980 | CDx Diagnostics | — |
| Completed | trūFreeze® Spray Cryotherapy Patient Registry NCT01802203 | US Endoscopy Group Inc. | — |
| Completed | Metformin Hydrochloride in Preventing Esophageal Cancer in Patients With Barrett Esophagus NCT01447927 | National Cancer Institute (NCI) | Phase 2 |
| Completed | Prevalence of Human Papillomavirus in Barrett Esophagus Compared With Controls NCT02549053 | University Hospital, Angers | N/A |
| Completed | Autologous Cell Sheets Transplantation After ESD in the Esophagus NCT02455648 | Matthias Löhr | N/A |
| Completed | Esophageal Protocol for Detection of Neoplasia in the Digestive Tract NCT01391208 | University of Michigan | Phase 1 |
| Unknown | Barrett's Esophagus Patient Registry NCT01776346 | Massachusetts General Hospital | — |
| Completed | Aceto-whitening in the Assessment of Gastrointestinal Neoplasia NCT01618643 | Portsmouth Hospitals NHS Trust | — |
| Completed | Ursodiol in Treating Patients With Barrett Esophagus and Low-Grade Dysplasia NCT01097304 | National Cancer Institute (NCI) | Phase 2 |
| Completed | On-demand PPI Therapy is Effective on Controlling Symptoms in Patients With Barrett's Esophagus. NCT04329000 | Kaohsiung Veterans General Hospital. | N/A |
| Completed | CLE for Assessment of Neoplasia After Mucosal Ablation or Resection of Gastrointestinal Neoplasia NCT01032044 | Mauna Kea Technologies | N/A |
| Terminated | Assessment of Zegerid on Esophageal pH in Patients With Barrett's Esophagus NCT01129778 | Stanford University | N/A |
| Completed | Detection Of Neoplastic Tissue in Barrett's Esophagus With In vivO Probe-based Confocal Endomicroscopy NCT00795184 | Mauna Kea Technologies | N/A |
| Completed | Does Laparoscopic Sleeve Gastrectomy Lead to Barrett's Esophagus, 5-year Esophagogastroduodenoscopy Findings: NCT04587310 | Eliana Al Haddad | — |
| Completed | Novel Method of Surveillance in Barrett's Esophagus NCT00955019 | Mayo Clinic | — |
| Completed | HALO Patient Registry: Ablation of Barrett's Esophagus NCT00848237 | Medtronic - MITG | N/A |
| Completed | Esomeprazole Magnesium With or Without Aspirin in Preventing Esophageal Cancer in Patients With Barrett Esopha NCT00474903 | National Cancer Institute (NCI) | Phase 2 |
| Completed | Confocal Laserscanning Microscopy for Detection of Barretts Esophagus NCT00449995 | Technical University of Munich | N/A |
| Completed | Efficacy and Safety of Sunitinib in Metastatic Gastric Cancer NCT00411151 | Johannes Gutenberg University Mainz | Phase 2 |
| Terminated | Pilot Study of Oral 852A for Elimination of High-Grade Dysplasia in Barrett's Esophagus NCT00386594 | Rogers, B.H. Gerald, M.D. | N/A |
| Terminated | Study of Cryotherapy Treatment of Barrett's Esophagus and Early Esophageal Cancer NCT00321958 | University of Maryland, Baltimore | — |
| Completed | Ablation of Intestinal Metaplasia Containing Dysplasia NCT00282672 | Medtronic - MITG | N/A |
| Completed | Defined Green Tea Catechin Extract in Preventing Esophageal Cancer in Patients With Barrett's Esophagus NCT00233935 | National Cancer Institute (NCI) | Phase 1 |
| Completed | Novel Imaging Techniques in Barrett's Esophagus NCT00576498 | Midwest Biomedical Research Foundation | N/A |
| Completed | Endoscopic Therapy of Early Cancer in Barretts Esophagus NCT00217087 | Mayo Clinic | Phase 2 |
| Completed | Micro-Layer Ablation of Barrett's Metaplasia- A Two-Phase, Multi-Center Trial - Extension of Follow-up to 5 Ye NCT00489268 | Covidien, GI Solutions | N/A |
| Terminated | Demographics and Findings of Upper Endoscopy Patients NCT00576992 | Midwest Biomedical Research Foundation | — |
| Completed | Methylene Blue Chromoendoscopy in Barrett's Esophagus NCT00587652 | Mayo Clinic | — |
| Active Not Recruiting | Novel Biomarkers in the Neoplastic Progression of Barrett's Esophagus NCT00431756 | Johns Hopkins University | — |
| Withdrawn | Safety of Photodynamic Therapy (PDT) in the Ablation of High-grade Dysplasia (HGD) in Barrett's Esophagus (BE) NCT01209013 | Pinnacle Biologics Inc. | Phase 3 |