NCT05216133

Biomarkers of Airway Disease, Barrett's and Underdiagnosed Reflux Noninvasively (BADBURN)

AERODIGESTIVE DISEASE IN THE WORLD TRADE CENTER EXPOSED FDNY COHORT: a Single Center Observational Study of Biomarkers of Airway Disease, Barrett's and Underdiagnosed Reflux Noninvasively (BADBURN)

• Status: Enrolling By Invitation
• Phase: —
• Study type: Observational
• Enrollment: 200 (estimated)
• Sponsor: NYU Langone Health · Academic / Other
• Sex: Male
• Age: 37 Years – 90 Years
• Healthy volunteers: Not accepted

Summary

A majority of Fire Department of New York (FDNY) World Trade Center (WTC) exposed rescue and recovery workers developed gastroesophageal reflux disease (GERD), a risk factor for Barrett's Esophagus (BE) and subsequent esophageal cancer. There is diminished health-related quality of life and productivity associated with aerodigestive diseases such as GERD and BE. This proposal will leverage the longitudinally phenotyped WTC exposed cohort, validate biomarkers of WTC-aerodigestive disease, and develop novel, noninvasive disease phenotyping of premalignant diseases such as BE, and identify potential targeted therapeutics to improve care.

Conditions

• Airway Disease
• Barrett Esophagus
• Gastroesophageal Reflux Disease

Timeline

• Start date: 2023-03-22
• Primary completion: 2027-06-01
• Completion: 2027-07-01
• First posted: 2022-01-31
• Last updated: 2025-06-05

Locations

1 site across 1 country: United States