| Not Yet Recruiting | Reflux Disease After Gastric Bypass Versus Sleeve Gastrectomy in Morbid Obese Patients: an Italian Study NCT04763993 | Niguarda Hospital | N/A |
| Not Yet Recruiting | Oral Fosamprenavir + Sodium Alginate for GERD NCT06704100 | Medical College of Wisconsin | Phase 2 |
| Enrolling By Invitation | Effect of Laparoscopic Sleeve Gastrectomy Versus Roux-en-Y Gastric Bypass on Gastroesophageal Reflux Disease: NCT03692455 | Clinica Gastrobese | — |
| Not Yet Recruiting | A Post-market Registry to Assess Safety and Performance of RefluxStop™ in the Treatment of GERD in General Hos NCT07004439 | Implantica CE Reflux Ltd. | N/A |
| Not Yet Recruiting | Mandibular Advancement Devices for Reflux in Obstructive Sleep Apnea NCT07049315 | Tuiuti University of Paraná | Phase 3 |
| Not Yet Recruiting | Intestinal Microbiota After PPI Treatment NCT07036627 | University of Bari | — |
| Completed | Efficacy of Gut-Brain Neuromodulators in the Treatment of Gastroesophageal Reflux Disease NCT06945237 | RenJi Hospital | N/A |
| Recruiting | Mechanistic and Clinical Outcomes of a Surgical Innovation Aimed at Minimizing GERD Associated With VSG (INNOV NCT06783751 | University of California, Irvine | N/A |
| Completed | Association Between Gastroesophageal Reflux Disease (GERD) Severity and Dental Caries NCT07108751 | Tanta University | — |
| Completed | Therapeutic Effect of Vonoprazan Versus Dexlansoprazole in Treatment of Gastroesophageal Reflux Disease NCT06778395 | Ayman Magd Eldin Mohammad Sadek | Phase 4 |
| Recruiting | Anti-reflux Mucosal Valvuloplasty Versus PPIs for GERD Treatment NCT06348420 | Qilu Hospital of Shandong University | N/A |
| Completed | Epidemiological Studies and Risk Factor Analysis of GERD in Xiamen City NCT06585176 | Zhongshan Hospital (Xiamen), Fudan University | — |
| Not Yet Recruiting | Gastroesophageal Reflux Disease Diagnostic Trial NCT06504134 | Changhai Hospital | — |
| Recruiting | Clinical Trial for the Comparative Evaluation of Acid Suppression and Symptom Management of Gastroesophageal R NCT06991348 | Carnot Laboratories | Phase 4 |
| Active Not Recruiting | Preserving the Pre-cardial Fat Pad During Sleeve Gastrectomy on Postoperative Gastroesophageal Reflux NCT06732661 | Beijing Chao Yang Hospital | N/A |
| Not Yet Recruiting | Zuojin Wan Combined With Woonosan Fumarate for the Treatment of GRD Combined With Depression NCT06481787 | Nanjing First Hospital, Nanjing Medical University | N/A |
| Unknown | Effect of Lidocaine Block on Gastroesophageal Reflux Disease NCT06304142 | Muhammad | N/A |
| Not Yet Recruiting | Anti-reflux Mucosal Ablation Therapy Randomized Sham Control Trial for Gastroesophageal Reflux Disease NCT06106100 | Far Eastern Memorial Hospital | N/A |
| Unknown | Stellate Ganglion Block on Gastroesophageal Reflux Disease NCT06319521 | Copka Sonpashan | N/A |
| Withdrawn | Clinical Effect of Stellate Ganglion Block on Gastroesophageal Reflux Disease NCT06215742 | Zeng Changhao | N/A |
| Unknown | Endoloop Mediated Cardioplication to Treat Gastroesophageal Reflux Disease NCT06153901 | Qilu Hospital of Shandong University | N/A |
| Completed | A Study to Evaluate Vonoprazan in Children Who Have Symptomatic Gastroesophageal Reflux Disease NCT06106022 | Phathom Pharmaceuticals, Inc. | Phase 1 |
| Withdrawn | Prospective Collection of Outcome Data Post POEM-TIF Procedure NCT04052581 | Johns Hopkins University | — |
| Unknown | Nursing Teaching Scheme for Patients With Gastroesophageal Reflux Disease NCT05937204 | Assiut University | N/A |
| Completed | Study to Evaluate the Efficacy and Safety of FEXUCLUE Tablet NCT05886933 | Daewoong Pharmaceutical Co. LTD. | — |
| Unknown | A Study to Evaluate the Efficacy and Safety of Tegoprazan in GERD Patients With Nighttime Heartburn NCT05701540 | HK inno.N Corporation | Phase 4 |
| Enrolling By Invitation | Biomarkers of Airway Disease, Barrett's and Underdiagnosed Reflux Noninvasively (BADBURN) NCT05216133 | NYU Langone Health | — |
| Completed | GCC Agonist Signal in the Small Intestine NCT05107219 | University of Wisconsin, Madison | Phase 1 |
| Completed | A Study to Evaluate the Improvement Effect on Subjective Symptom of FEXUCLUE Tab NCT05660122 | Daewoong Pharmaceutical Co. LTD. | — |
| Completed | Study to Evaluate the Improvement Effect on Subjective Symptom of FEXUCLUE Tab NCT05614752 | Daewoong Pharmaceutical Co. LTD. | — |
| Unknown | Anti-Reflux Mucosal Ablation(ARMA) and Anti-Reflux Mucosectomy(ARMS) in Gastroesophageal Reflux Disease NCT05422404 | Taipei Veterans General Hospital, Taiwan | N/A |
| Completed | Mass Balance Study of [14C]X842 in Healthy Adult Male Subjects NCT07107672 | Jiangsu Sinorda Biomedicine Co., Ltd | Phase 1 |
| Unknown | Sleeve Gastrectomy With Reestablishment of the Acute Angle of His (SG-REACH) in Obese Patients NCT05452980 | Zhen Jun Wang | N/A |
| Completed | Gastroesophageal Reflux Disease (GERD) Among ICU Survivors NCT05193266 | Sanjay Gandhi Postgraduate Institute of Medical Sciences | — |
| Completed | Determination of Change in Reflux Disease After Sleeve Gastrectomy by Intraluminal Impedance and pH-meter NCT05405816 | Fatih Sultan Mehmet Training and Research Hospital | N/A |
| Completed | A Study to Compare PK, PD and Safety of the AD-214 and AD-2141 NCT05062876 | Addpharma Inc. | Phase 1 |
| Unknown | The Effect of PPI in Preventing Gastroesophageal Reflux Disease of Seafarers NCT04696783 | Fifth Affiliated Hospital, Sun Yat-Sen University | Phase 3 |
| Completed | Antireflux Ablation of the Cardia Mucosa vs Placebo for the Treatment of Gastroesophageal Reflux Disease NCT04711655 | Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal | N/A |
| Completed | A Study to Compare the Safety, Pharmacokinetics and Pharmacodynamics of YPI 011 to Rabeprazole in Healthy Adul NCT04703868 | Yungjin Pharm. Co., Ltd. | Phase 1 |
| Recruiting | Proximal Gastrectomy Anterior Anastomosis With Pyloroplasty Versus Esophagogastric Anastomosis for Gastric Can NCT05514769 | Nanchong Central Hospital | N/A |
| Completed | A Study to Compare PK, PD and Safety of the AD-214-02 and Rabeprazole NCT04622358 | Addpharma Inc. | Phase 1 |
| Completed | Study to Evaluate the Influence of Tegoprazan on the Pharmacokinetics of Proguanil in Healthy Volunteers NCT04568772 | Seoul National University Hospital | Phase 1 |
| Completed | A Study to Compare PK, PD and Safety of the AD-214 10/600mg and Rabeprazole NCT04494243 | Addpharma Inc. | Phase 1 |
| Enrolling By Invitation | Transoral Incisionless Fundoplication Database Repository (TIF) NCT04306380 | Indiana University | — |
| Active Not Recruiting | Evaluation of Upper Esophageal Sphincter Motor Activity in Patients with Extra Esophageal Reflux Symptoms NCT06773702 | IRCCS Azienda Ospedaliero-Universitaria di Bologna | — |
| Withdrawn | A Study of Dexlansoprazole Modified Release (MR) in Gastroesophageal Reflux Disease (GERD) Participants in the NCT04311541 | Takeda | — |
| Completed | Survey Study on Barrett's Esophagus Screening NCT04408105 | University of Colorado, Denver | — |
| Recruiting | Real-life Study of Changes of Gastroesophageal Reflux Disease Manifestations Due to Behavioural and Diet Adher NCT04255693 | Federal State Budgetary Scientific Institution "Federal Research Centre of Nutrition, Biotechnology | N/A |
| Unknown | GaStroEsophageal effeCt of indobUfen Versus aspiRin in Patients Undergoing Dual antiplatElet Therapy NCT04129008 | Beijing Anzhen Hospital | Phase 4 |
| Withdrawn | Antireflux Ablation Therapy (ARAT) Vs Antireflux Mucosectomy (ARMS) In The Management Of Gastroesophageal Refl NCT04036942 | Coordinación de Investigación en Salud, Mexico | N/A |
| Unknown | Epi-GERD Study: Epidemiological Evaluation in Patients With Gastro-Esophageal Reflux Disease (GERD) NCT04094402 | Scandinavia Pharma | — |
| Enrolling By Invitation | The Johns Hopkins Heartburn Center Registry NCT03853772 | Johns Hopkins University | — |
| Completed | Cognitive Behavioral Therapy for Insomnia (CBTI) in GERD Patients With Insomnia NCT03904472 | University of Michigan | N/A |
| Completed | Manual Therapy Effects on Upper and Lower Esophageal Sphincter Pressures NCT03871426 | University Hospital, Motol | — |
| Unknown | Laparoscopic Sleeve Gastrectomy With or Without Hiatal Hernia Repair in Morbidly Obese Patients NCT03776669 | National Taiwan University Hospital | N/A |
| Unknown | Efficacy of Zinc L-carnosine in Maintaining Remission of Gastroesophageal Reflux Disease NCT03467438 | Fondazione IRCCS Policlinico San Matteo di Pavia | Phase 4 |
| Completed | Laparoscopic Total vs Partial Fundoplication in Patients With Atypical Symptoms of Gastroesophageal Reflux Dis NCT05647668 | Mykola Paranyak | N/A |
| Active Not Recruiting | Transoral Fundoplication Prior to Sleeve Gastrectomy Versus RNY Gastric Bypass on GERD Symptoms in Bariatric P NCT05365087 | Lexington Health Incorporated | — |
| Completed | Gastroesophageal Reflux Disease in Azerbaijan NCT03616119 | Sevda Aghayeva | — |
| Completed | A Trial of C13-CAC Breath Test in PPI Resistant GERD Patients NCT03284177 | Otsuka Pharmaceutical Co., Ltd. | Phase 2 |
| Completed | Diaphragmatic Myofascial Release in Gastroesophageal Reflux Disease NCT03299985 | Cardenal Herrera University | N/A |
| Completed | Comparison of the Effect of Rabeprazole 50 mg DDR Capsules and 20 mg Enteric-coated Tablets NCT03037606 | Neutec Ar-Ge San ve Tic A.Ş | Phase 4 |
| Terminated | PREA, PK And Safety PASS Study Of IV Pantoprazole In Pediatric Subjects NCT02401035 | Pfizer | Phase 4 |
| Completed | LINX Reflux Management System in Subjects With GERD Who Have Previously Undergone a Laparoscopic Sleeve Gastre NCT02429830 | Torax Medical Incorporated | N/A |
| Unknown | Radiofrequency Ablation in Patients With Barrett's Esophagus NCT02793479 | Matthias Paireder | — |
| Completed | PH Metry Study to Compare the Antacid Activity of Z0063 Versus Gaviscon Double Action Tablets, in Healthy Adul NCT03069963 | Sanofi | Phase 1 |
| Completed | Scintigraphy Study to Compare the Antireflux Activity of the Z0063 Versus Gaviscon Double Action Tablets, in H NCT03065816 | Sanofi | Phase 1 |
| Unknown | Diagnostic Value of Linked Color Imaging for Minimal Change Esophagitis in Nonerosive Reflux Esophagitis and G NCT03068572 | Affiliated Hospital to Academy of Military Medical Sciences | — |
| Completed | Efficacy and Safety of Dexlansoprazole on Heartburn Relief in Chinese Patients NCT02873689 | Takeda | Phase 3 |
| Unknown | Effect of Proton Pump Inhibitor and Mosapride on Acid Pocket in Gastroesophageal Reflux Disease NCT02984930 | Gangnam Severance Hospital | N/A |
| Completed | Genotype-supported Versus Conventional Proton Pump Inhibitor Dosing NCT02930824 | University of Florida | N/A |
| Unknown | Symptom Assessment for Patients With Gastro-esophageal Reflux Disease Receiving Helicobacter Pylori Eradicatio NCT02934152 | National Taiwan University Hospital | Phase 4 |
| Completed | Swallowable Sponge Cell Sampling Device and Next Generation Sequencing in Detecting Esophageal Cancer in Patie NCT02890979 | OHSU Knight Cancer Institute | N/A |
| Completed | Efficacy of Gaviscon-Advance® in Suppressing Post-supper Acid-pocket and Night-time Acid-reflux in Obese Parti NCT03516188 | Universiti Sains Malaysia | Phase 2 / Phase 3 |
| Unknown | Registry of Outcomes From AntiReflux Surgery NCT02923362 | The Heartburn Foundation | — |
| Completed | Impact of Head of Bed Elevation in Symptoms of Patients With Gastroesophageal Reflux Disease NCT02706938 | Universidad Nacional de Colombia | N/A |
| Completed | A Trial of IW-3718 for 8 Weeks in Patients With Symptomatic Gastroesophageal Reflux Disease (GERD) NCT02637557 | Ironwood Pharmaceuticals, Inc. | Phase 2 |
| Completed | Dietary Carbohydrate and GERD in Veterans NCT02384551 | VA Office of Research and Development | N/A |
| Completed | Endoscopic Tri-Modal Imaging to Distinguish Functional Dyspepsia From Reflux Disease NCT02685150 | Chinese PLA General Hospital | N/A |
| Completed | Reflux-Induced Oxidative Stress in Barrett's Esophagus: Response, Repair, and Epithelial-Mesenchymal-Transitio NCT02579460 | Dallas VA Medical Center | N/A |
| Completed | Should I Continue Taking My Acid Reflux Medication? Development and Pilot Testing of a Patient Decision Aid NCT02558049 | University of Ottawa | N/A |
| Terminated | RELIEF Europe Study NCT02762487 | Torax Medical Incorporated | N/A |
| Unknown | Treatment Effect Between Dexlansoprazole and Double-dose Lansoprazole in Obesity Patients With Reflux Esophagi NCT02759393 | National Cheng-Kung University Hospital | Phase 4 |
| Unknown | The Effect of Non Invasive Electrical Stimulation Therapy on Gastroesophageal Reflux Disease (GERD) Symptoms - NCT02500264 | Rabin Medical Center | N/A |
| Unknown | Radiofrequency Energy Delivery for Gastroesophageal Reflux Disease NCT03223116 | Changhai Hospital | N/A |
| Unknown | The Effect of PPI Therapy on Weight, Gut Microbiome, and Expression of GPR41 and GPR43 NCT02457104 | University of Colorado, Denver | — |
| Completed | Factors Influencing the Human Gut Microbiome Profile in Multi-ethnic Groups of the Singapore Community (FAMES) NCT02893709 | Changi General Hospital | N/A |
| Completed | Dexlansoprazole in Asian Participants With Gastroesophageal Reflux Disease NCT02351960 | Takeda | Phase 4 |
| Unknown | Lesogaberan in Chinese Patients With Refractory Reflux Symptoms NCT02818309 | National Taiwan University Hospital | Phase 2 |
| Unknown | Esomeprazole Plus Alginate vs. Esomeprazole Alone for Treatment of Nighttime Reflux Symptom and Sleep Disturba NCT02277886 | Chang Gung Memorial Hospital | Phase 4 |
| Completed | Can Quercetin Increase Claudin-4 and Improve Esophageal Barrier Function in GERD? NCT02226484 | University of North Carolina, Chapel Hill | Phase 1 |
| Terminated | Registry to Compare Two Surgical Treatments for GERD NCT02211105 | American Gastroenterological Association | — |
| Completed | PK Study With Pantoprazole in Obese Children and Adolescents NCT02186652 | Phillip Brian Smith | Phase 1 |
| Completed | The Difference of Reflux Pattern Between the Patients Who Have Postprandial Reflux Symptoms NCT02154659 | Yonsei University | N/A |
| Unknown | The Efficacy of Neiguan (P6 Point) Acupressure in Patients With Gastroesophageal Reflux Disease (GERD) NCT02255071 | China Medical University Hospital | N/A |
| Completed | Comparing Clinical Efficacy of One-Week Dual Delayed-Release Dexlansoprazole and Esomeprazole for GERD Grade A NCT03128736 | Kaohsiung Medical University Chung-Ho Memorial Hospital | Phase 4 |
| Completed | Absolute Bioavailability of YH4808 With Accelerator Mass Spectrometry(AMS)-Based Microdose Study NCT02072447 | Seoul National University Hospital | EARLY_Phase 1 |
| Completed | Sensory Evaluation of Dexlansoprazole Delayed-Release Orally Disintegrating Tablets NCT02096458 | Takeda | Phase 1 |
| Completed | Esophageal Cytology With FISH in Detecting Esophageal Cancer NCT02100189 | OHSU Knight Cancer Institute | N/A |
| Unknown | Decision Aid for Gastroesophageal Reflux Disease Management NCT01641887 | Massachusetts General Hospital | — |
| Completed | Approach to Hiatal Hernia Repair Based on Collagen Study NCT04152798 | Grubnik Volodymyr | N/A |
| Completed | The Efficacy of Lansoprazole and Domperidone Combination on Intragastric and Intraesophageal Acidity NCT02958046 | Neutec Ar-Ge San ve Tic A.Ş | Phase 4 |
| Completed | A Double-blind Comparative Study of the Efficacy and Safety of E3810 10mg Once and Twice Daily in Maintenance NCT02135107 | Eisai Co., Ltd. | Phase 3 |
| Withdrawn | Clinical Study, Multicenter, Randomized With 2 Arms of Pantoprazole + Domperidone and Pantoprazole Isolated at NCT01710462 | Eurofarma Laboratorios S.A. | Phase 3 |
| Completed | Prospective Trial on the Clinical Feasibility of a New Full Thickness Endoscopic Plication Device for Patients NCT01798212 | Krankenhaus Barmherzige Schwestern Linz | N/A |
| Completed | Compound Sodium Alginate Double Action Chewable Tablets 4-hour Esophageal pH Study in GERD Patients NCT01872897 | Reckitt Benckiser Healthcare (UK) Limited | Phase 3 |
| Completed | Compound Sodium Alginate Double Action Chewable Tablet Symptomatic Relief Study NCT01869491 | Reckitt Benckiser Healthcare (UK) Limited | Phase 3 |
| Completed | Gastroesophageal Reflux Treatment in Scleroderma NCT01878526 | Khon Kaen University | Phase 3 |
| Completed | Diagnostic of Transient Lower Esophageal Sphincter Relaxation With Combined Impedance and High Resolution Mano NCT01844440 | University Hospital, Bordeaux | N/A |
| Completed | Role of Pepsin Assay in Wheezy Infants NCT02685436 | Mansoura University Children Hospital | Phase 4 |
| Active Not Recruiting | Morphological Markers of Gastroesophageal Reflux Disease (GERD) NCT01921686 | Baylor College of Medicine | — |
| Unknown | Randomized, Double Blind, Placebo Control Trial to Evaluate the Efficacy of Wu-Chu-Yu Tang on Gastroesophageal NCT01822106 | China Medical University Hospital | Phase 4 |
| Completed | The Role of HIF-2a in the Pathogenesis of Reflux Esophagitis NCT01733810 | Dallas VA Medical Center | N/A |
| Unknown | LGG for Prevention of Infectious Complications During PPI Treatment in Children NCT01782118 | Medical University of Warsaw | Phase 4 |
| Completed | A Study of Local Effect and Safety of a Single PPC-5650 Dose on Reflux Pain During Pain Stimulation in the Eso NCT01818570 | Asbjørn Mohr Drewes | Phase 1 |
| Withdrawn | A Study to Evaluate the Role of Alternative Medicine in Difficult to Treat GERD Patients NCT00591877 | Midwest Biomedical Research Foundation | N/A |
| Completed | Efficacy of Imipramine for Treatment of Patients With Esophageal Hypersensitivity/ Functional Heartburn NCT01753128 | Mahidol University | Phase 3 |
| Completed | Cough Reflex Sensitivity and Bronchial Hyper-responsiveness NCT01777867 | Mayo Clinic | — |
| Completed | Neonatal Gastro-Esophageal Reflux Disease (GERD) Management Trial NCT02486263 | Sudarshan Jadcherla | N/A |
| Withdrawn | Reflux Disease in Head and Neck Cancer Patients Undergoing Radiation Therapy NCT00928161 | M.D. Anderson Cancer Center | N/A |
| Recruiting | Domperidone in Treating Patients With Gastrointestinal Disorders NCT01696734 | M.D. Anderson Cancer Center | Phase 3 |
| Suspended | Narrow Band Imaging Project on Barrett's Esophagus NCT01580631 | Midwest Biomedical Research Foundation | — |
| Completed | Safety and Efficacy of Dexlansoprazole Delayed-Release Capsules for Healing of Erosive Esophagitis and Mainten NCT01642615 | Takeda | Phase 2 |
| Completed | Safety and Efficacy of Dexlansoprazole Delayed-Release Capsules in Treating Symptomatic Non-Erosive Gastroesop NCT01642602 | Takeda | Phase 2 |
| Completed | Cardiaplication: A Novel Antireflux Operation NCT02060500 | Emory University | N/A |
| Completed | Long-term Outcome of Laparoscopic Hiatal Hernia Repair With or Without Alloderm Mesh at a University Hospital NCT01776827 | University of Nebraska | — |
| Completed | Using Electrical Bioimpedance Assessments to Estimate Perioperative Total Body Water and Postoperative Fluid N NCT02200055 | United States Naval Medical Center, Portsmouth | N/A |
| Completed | Phase IV Study of the Impact of Dietary Fibers on Symptoms and Esophageal Motility in Patients With Non-erosiv NCT01882088 | Russian Academy of Medical Sciences | Phase 4 |
| Completed | Stretta In Reflux Uncontrolled by IPP NCT01682265 | Nantes University Hospital | N/A |
| Withdrawn | Predictors of Proton Pump Inhibitor (PPI) Response in Eosinophilic Esophagitis NCT01479231 | Mayo Clinic | Phase 1 / Phase 2 |
| Completed | Selective 5-HT4 Receptor Agonist and Proton Pump Inhibitor (PPI) in Subjects With Gastroesophageal Reflux Dise NCT01472939 | Shire | Phase 2 |
| Completed | The Use of International GerdQ Questionnaire NCT01489735 | AstraZeneca | — |
| Completed | Anthropometric Measures and Severity of Gastroesophageal Reflux Disease NCT01954667 | Ain Shams University | — |
| Completed | Ilaprazole for the Treatment of Gastroesophageal Reflux Disease (GERD) in Chinese Patients NCT02860624 | Livzon Pharmaceutical Group Inc. | Phase 3 |
| Completed | Analysis of Biopsies From the Upper Gastrointestinal Tract NCT01576289 | Medical University of Graz | — |
| Completed | Symptom Control and Impact on Daily Life in Patients With Gastroesophageal Reflux Disease NCT01432392 | AstraZeneca | — |
| Withdrawn | Double-dose Rabeprazole Accelerates and Sustains the Control of Symptoms in Patients With NERD NCT01391715 | Inje University | Phase 3 |
| Completed | To Assess the Efficacy of Esomeprazole 20mg Once Daily in Subjects Who Still Had Heartburn After Receiving Rab NCT01397084 | AstraZeneca | Phase 4 |
| Completed | Effect of Long-Term Electrical Stimulation on LES Pressure and Esophageal Acid Exposure in Patients With GERD NCT01574339 | EndoStim Inc. | N/A |
| Completed | Pharmacodynamic and Pharmacokinetic Study of E3710 Following Oral Administration to Healthy, Male, Japanese Su NCT01390714 | Eisai Co., Ltd. | Phase 1 |
| Completed | Reflux Disease Therapy in the Management of Childhood Asthma-data Entry and Analysis Only NCT01536457 | Children's Center for Digestive Health Care | — |
| Completed | Diagnostic Value of Flexible Spectral Imaging Color Enhancement (FICE) Plus Probe-based Confocal Laser Endomic NCT02336100 | King Chulalongkorn Memorial Hospital | N/A |
| Terminated | Rubber Band Ligation and Mucosectomy for Gastroesophageal Reflux Disease (GERD) NCT01199679 | Cook Group Incorporated | N/A |
| Completed | Randomized EsophyX Versus Sham / Placebo Controlled TIF Trial: The RESPECT Study NCT01136980 | EndoGastric Solutions | N/A |
| Unknown | Narrow-band Imaging, Autofluorescence Imaging and Gastroesophageal Reflux Disease NCT01504971 | Chinese PLA General Hospital | — |
| Terminated | An Explorative Trial to Evaluate the Pharmacodynamic Effect of SPD557 on Reflux Parameters in Refractory GERD NCT01370863 | Shire | Phase 2 |
| Completed | Can We Predict Who Has Gastroesophageal Reflux Disease (GERD)? NCT01204931 | Vanderbilt University | — |
| Completed | Measurement of Gastric Secretion by MRI Under Inhibition by ProtonPump Inhibitors in Healthy Subjects & in GER NCT01212614 | University of Zurich | N/A |
| Completed | A Cross-sectional Study on the Prevalence and Extraesophageal Symptoms of Gastroesophageal Reflux Disease(GERD NCT01215305 | AstraZeneca | — |
| Completed | Efficacy and Safety of Sodium Alginate Oral Suspension to Treat Non-erosive Gastro-esophageal Reflux Disease NCT01338077 | Chang Gung Memorial Hospital | Phase 3 |
| Terminated | Effect of RING on Gastroesophageal Reflux (GERD) After RYGBP NCT01212835 | Clinica Gastrobese | N/A |
| Unknown | Symptom Assessment for GERD Patients Receiving H. Pylori Eradication NCT01249482 | National Taiwan University Hospital | — |
| Completed | The Study to Describe Symptom Control and Impact on Daily Life in Gastroesophageal Reflux Disease (GERD) Patie NCT01200550 | AstraZeneca | — |
| Completed | Feasibility Study for Evaluating the Effect of Electrical Stimulation on Lower Esophageal Sphincter Pressure a NCT01578642 | EndoStim Inc. | Phase 2 |
| Completed | The Efficacy of i-Scan for Detecting Reflux Esophagitis NCT01381991 | Konkuk University Hospital | N/A |
| Unknown | Prevalence of Gastroesophageal Reflux Disease in Peritoneal Dialysis and Hemodialysis Patients NCT01634672 | Song Kyung Ho | — |
| Completed | Can E-cadherin Found in Tissue/Blood be Valuable in Identifying & Monitoring Patients With Post-proton Pump In NCT01149395 | University of North Carolina, Chapel Hill | Phase 1 |
| Completed | Observational Study (This Means That no Drug is Tested) in Patients Suffering of Gastroesophageal Reflux Disea NCT01601379 | Janssen-Cilag International NV | — |
| Completed | Transoral Incisionless Fundoplication (TIF) Registry Study for Treatment of Gastroesophageal Reflux Disease (G NCT01118585 | EndoGastric Solutions | N/A |
| Unknown | Ilaprazole for the Treatment of Gastroesophageal Reflux Disease (GERD) in Chinese Patients NCT01107938 | Livzon Pharmaceutical Group Inc. | Phase 2 |
| Completed | Transoral Incisionless Fundoplication (TIF) Versus Sham for Treatment of Gastroesophageal Reflux Disease (GERD NCT01110811 | EndoGastric Solutions | N/A |
| Completed | Temple Registry for the Investigation of African American Gastrointestinal Disease Epidemiology NCT01262755 | Temple University | — |
| Unknown | Effect of Esomeprazole 40 mg.Daily for 7 Days on Acid Reflux and Related Arousals During Sleep in Patients Wit NCT01089959 | Southern Arizona VA Health Care System | Phase 2 / Phase 3 |
| Terminated | Gastric Accommodation and Gastroesophageal Reflux NCT01078064 | Nationwide Children's Hospital | — |
| Completed | Do Acid Sensing Ion Channels Contribute to Heartburn? NCT01095133 | University of North Carolina, Chapel Hill | Phase 1 |
| Completed | Minimal Change Esophagitis by i-Scan Endoscopy in Dyspeptic Patients NCT01742377 | Prince of Songkla University | — |
| Terminated | Quality of Life in Barrett's Esophagus and Gastro-Esophageal Reflux Disease NCT01572974 | Midwest Biomedical Research Foundation | — |
| Completed | Effect of Nortriptyline in Cortical Representation of Heartburn in Nonerosive Reflux Disease (NERD) Patients NCT01065649 | Universidade de Passo Fundo | Phase 3 |
| Completed | Effect of Continuous Positive Airway Pressure (CPAP) on Lower Esophageal Sphincter Pressure in Morbidly Obese NCT01099735 | Oregon Health and Science University | — |
| Completed | Tri Staple Technology Stapler Used in Gastric Bypass NCT01026103 | Medtronic - MITG | N/A |
| Completed | Efficacy Study of AGSPT201 Tablet to Treat Gastroesophageal Reflux Disease NCT01400945 | Ahn-Gook Pharmaceuticals Co.,Ltd | Phase 3 |
| Completed | The Effect of Lansoprazole in Combination With Ecabet Sodium for Gastroesophageal Reflux Disease NCT01039558 | Seoul National University Hospital | N/A |
| Completed | A Study to Estimate Effect of 4 Different Doses of AZD3355 on Reflux Episodes, Which Patients With Gastroesoph NCT01043185 | AstraZeneca | Phase 2 |
| Completed | Prevalence of Gastroesophageal Reflux Disease in Primary Care Patients With Upper Gastrointestinal Symptoms NCT01020890 | AstraZeneca | — |
| Completed | Investigate the Effect of Different Doses of Lesogaberan (AZD3355) as add-on to PPI in GERD Patients With Part NCT01005251 | AstraZeneca | Phase 2 |
| Unknown | The Effect of High PCO2 Solution on Esophageal Acid Sensation NCT01128608 | Southern Arizona VA Health Care System | N/A |
| Completed | A Study to Evaluate the Efficacy and Safety of Arbaclofen Placarbil (XP19986) as Adjunctive Therapy in Subject NCT00978016 | XenoPort, Inc. | Phase 2 |
| Completed | Study to Evaluate the Effect of a Very Low Carbohydrate Diet on Gastroesophageal Reflux Disease NCT00998244 | University of North Carolina, Chapel Hill | N/A |
| Terminated | Detection of Minimal Change Esophagitis Using Confocal Laser Endomicroscopy NCT00954070 | National University Hospital, Singapore | — |
| Completed | Diagnosis and Response to Treatment Using a Reliable Gastroesophageal Reflux Disease (GERD) Questionnaire: An NCT00963144 | AstraZeneca | — |
| Completed | Prevalence and Impact in Work Productivity of Gastroesophageal Reflux Disease (GERD) in Primary Care Patients NCT00914342 | AstraZeneca | — |
| Completed | The Role of Anti-Reflux Surgery for Gastroesophageal Reflux Disease in Premature Infants With Bronchopulmonary NCT00926276 | The University of Texas Health Science Center, Houston | Phase 4 |
| Completed | The Clinical Significance of Minimal Change in Reflux Esophagitis Based on the Gastroesophageal Reflux Disease NCT00901004 | AstraZeneca | — |
| Completed | Clinical Studies on Bile Acids in Barrett's Esophagus NCT00858858 | US Department of Veterans Affairs | N/A |
| Unknown | Effect of Rozerem on the Perception of GERD Symptoms in Patients With Chronic Insomnia. NCT01128582 | Southern Arizona VA Health Care System | Phase 3 |
| Completed | Partial Response to PPI Treatment: The Cost to Society and the Burden to the Patient - a Study in France NCT00842855 | AstraZeneca | — |
| Completed | Relationship Between Gastroesophageal Reflux Disease and Dental Erosion NCT04595500 | University of Beykent | — |
| Completed | Pantoprazole 20/40 mg in the Treatment of Symptomatic Reflux Disease With Focus on Sleep Disorders NCT00830115 | Nycomed | — |
| Completed | Efficacy of Pantoprazole 20/40 mg Once Daily (od) in Patients Older Than 12 Years Who Have Gastrointestinal Sy NCT00829738 | Nycomed | — |
| Completed | Gastric Bypass After Previous Anti-reflux Surgery NCT01041105 | University of California, San Francisco | — |
| Completed | Survey to Describe Impact of Reflux Disease on Everyday Life in GERD Patients Before and After 4 Weeks Treatme NCT00786773 | AstraZeneca | — |
| Unknown | SThe Effects of Melatonin on GERD Symptoms NCT00564590 | Rabin Medical Center | Phase 1 / Phase 2 |
| Completed | Prevalence of EED and Quality of Life Evaluated by Gastroesophageal Reflux Disease (GERD)-Q in Korean GERD Pat NCT00768196 | AstraZeneca | — |
| Completed | Symptoms and Management Strategies in Gastroesophageal Reflux Disease (GERD) NCT00768443 | AstraZeneca | — |
| Completed | Role of Mosapride in Patients With Gastroesophageal Reflux Disease NCT00729339 | Lotung Poh-Ai Hospital | Phase 4 |
| Completed | Waist Circumference Versus Body Mass Index to Predict Severity of Gastroesophageal Reflux Disease NCT00698178 | Lotung Poh-Ai Hospital | — |
| Completed | The Role Of Gastroesophageal Reflux Disease (GERD) in Eosinophilic Esophagitis NCT00728481 | Mayo Clinic | Phase 2 / Phase 3 |
| Completed | Endoscopic Findings in Patients With Typical Gastroesophageal Reflux Disease (GERD) Symptoms NCT00730106 | Lotung Poh-Ai Hospital | — |
| Completed | Effect of Pantoprazole 40mg Daily vs Placebo on Power Spectral Analysis of the Sleep EEG of Patients With GERD NCT00674245 | Southern Arizona VA Health Care System | Phase 2 / Phase 3 |
| Completed | Local Phase IV, Gastroesophageal Reflux Disease (GERD) Sleep Study US NCT00660660 | AstraZeneca | Phase 4 |
| Completed | Study to Compare Different Formulations of AZD3355 NCT00688402 | AstraZeneca | Phase 1 |
| Completed | Drug Interaction Study Between AZD3355 and Nexium NCT00684190 | AstraZeneca | Phase 1 |
| Terminated | Efficacy And Safety Of PF-00885706 For The Relief Of Symptoms In Subjects With Gastro-esophageal Reflux Diseas NCT00730665 | Pfizer | Phase 2 |
| Completed | PillCam® ESO 2 in Esophageal Pathologies NCT00885469 | Medtronic - MITG | — |
| Completed | A Study of Nexium (Esomeprazole) 40 mg Once Daily in Subjects With Symptoms of Gastroesophageal Reflux Disease NCT00734097 | AstraZeneca | Phase 4 |
| Terminated | The Frequency of Eosinophilic Esophagitis in Patients With Heartburn That is Refractory to Proton Pump Inhibit NCT01404832 | Dallas VA Medical Center | Phase 4 |
| Terminated | What is the Predictive Value of the Reflux Impact Scale NCT00536328 | AstraZeneca | — |
| Completed | Efficacy of Pantoprazole in Patients Older Than 12 Years Who Have Symptoms of Non-Erosive Reflux Disease (NERD NCT00561730 | Nycomed | — |
| Unknown | Determinants of Efficacy of EsophyX Treatment in Gastro-Esophageal Reflux Disease NCT00498082 | Cliniques universitaires Saint-Luc- Université Catholique de Louvain | — |
| Completed | Diagnostic Efficacy of Narrow Band Imaging in Patients With Gastroesophageal Reflux Disease NCT00886197 | National Taiwan University Hospital | — |
| Completed | Evaluation of Topical Lidocaine Spray as Adjuvant to Upper Gastrointestinal Endoscopy in Children NCT00521703 | Hospital Infantil Cândido Fontoura | Phase 3 |
| Completed | Pharmacokinetics of Immediate-Release vs. Delayed-Release Omeprazole in Gastroparesis NCT00492622 | University of Louisville | Phase 4 |
| Completed | Open-label Comparison of 24hr Gastric pH on Days 1, 2, 7 With Once-daily Administration of Lavoltidine 40 mg. NCT00551473 | GlaxoSmithKline | Phase 1 |
| Completed | Improving Metoclopramide Prescribing Practices at Penn Through a Physician-targeted Intervention NCT01126034 | University of Pennsylvania | N/A |
| Terminated | The CONQUEST-Study. Evaluation of Clinical Endpoints for Treatment-induced Changes in GERD-related Symptoms (B NCT00449813 | Takeda | Phase 4 |
| Completed | Gastroesophageal Reflux Disease (GERD) Before and After Gastric Bypass NCT00951093 | Clinica Gastrobese | — |
| Completed | Structure and Function of the Gastro-esophageal Junction NCT01053585 | University of Zurich | N/A |
| Completed | An Observational Clinical Feasibility Study of the Magnetic Esophageal Sphincter NCT01058070 | Torax Medical Incorporated | N/A |
| Withdrawn | Nasopharyngeal 24 Hour pH Monitoring in Health Adult Volunteers NCT00584675 | University of California, Davis | N/A |
| Unknown | A Prospective Randomized Trial Comparing Laparoscopic Nissen Against Anterior Partial Fundoplication in Treati NCT00480285 | Chinese University of Hong Kong | Phase 3 |
| Terminated | Prescription Methods Assessment Project (PMAP) NCT00393653 | American Academy of Family Physicians | N/A |
| Completed | Evaluation of 24-Hour Intragastric pH Using Esomeprazole, Lansoprazole, and Pantoprazole in Hispanic Patients NCT00410592 | AstraZeneca | Phase 4 |
| Completed | Feasibility of Placing Bravo PH Capsule in Proximal Esophagus NCT00378898 | Vanderbilt University Medical Center | N/A |
| Completed | Symptom Adapted Therapy in GERD Patients NCT00343161 | AstraZeneca | Phase 4 |
| Completed | Safety and Efficacy Study of Axid Use in Infants Suffering From Gastroesophageal Reflux Disease (GERD) NCT00373334 | Braintree Laboratories | Phase 3 |
| Completed | Effects of AFQ056 and Baclofen on Meal-Induced Gastroesophageal Reflux NCT00414856 | Novartis | Phase 1 |
| Completed | The Use of Lansoprazole to Treat Infants With Symptoms of Gastroesophageal Reflux NCT00324974 | Takeda | Phase 3 |
| Completed | Safety and Efficacy of Dexlansoprazole Modified Release Formulation to Treat Gastroesophageal Reflux Disease NCT00321984 | Takeda | Phase 3 |
| Completed | Comparison of the Classical Healing Concept With the Complete Remission Concept After Treatment With Pantopraz NCT00325676 | Takeda | Phase 4 |
| Completed | Study Using Esomeprazole as a Diagnostic Test for GERD in Patients With NCCP NCT00786695 | National University Hospital, Singapore | N/A |
| Completed | A Study To Investigate The Effectiveness Of AH234844 (Lavoltidine) Compared With NEXIUM And Ranitidine. NCT00405119 | GlaxoSmithKline | Phase 2 |
| Completed | Role of Pain Modulation in GERD Patients Who Failed Standard Dose PPI NCT00539240 | US Department of Veterans Affairs | Phase 2 / Phase 3 |
| Unknown | The Proton Pump Inhibitor (PPI) Test for the Extraesophageal Manifestation of GERD NCT00539786 | Samsung Medical Center | N/A |
| Completed | Necessity of Esophageal Dissection During Laparoscopic Fundoplication NCT00287612 | Children's Mercy Hospital Kansas City | N/A |
| Completed | Evaluation of Patients With Non-cardiac Chest Pain NCT00476398 | Brigham and Women's Hospital | Phase 4 |
| Completed | Safety and Quality of Life Study of Dexlansoprazole Modified Release Formulation to Treat Heartburn NCT00255190 | Takeda | Phase 3 |
| Completed | Gastroesophageal Reflux and Cardiorespiratory Problems NCT03053609 | University of Turin, Italy | — |
| Recruiting | Progression of Gastroesophageal Reflux Disease and Barrett's Esophagus and the Creation of a Barrett's Registr NCT00574327 | Midwest Biomedical Research Foundation | — |
| Completed | Efficacy and Safety of Dexlansoprazole Modified Release Formulation to Treat Heartburn NCT00251745 | Takeda | Phase 3 |
| Completed | Esomeprazole in PPI Failures - IMPROVE NCT00272701 | AstraZeneca | Phase 4 |
| Completed | Safety and Efficacy of Dexlansoprazole Modified Release Formulation to Treat Heartburn NCT00251758 | Takeda | Phase 3 |
| Completed | Foreshortened Esophagus and Its Surgical Therapy NCT00507377 | University of Bologna | — |
| Completed | Evaluation of Efficiency of Esophageal Capsule Endoscopy in the Screening of Patients With Gastroesophageal Re NCT00217347 | Nantes University Hospital | N/A |
| Completed | Treatment of Gastroesophageal Reflux Disease in 12-16 Year Old Patients With Rabeprazole NCT00132496 | Eisai Inc. | Phase 2 |
| Completed | A Study to Evaluate the Effect of Lansoprazole on Hospitalized Neonates With Gastroesophageal Reflux Disease NCT00174928 | Takeda | Phase 1 |
| Completed | Role of Pain Modulation in GERD Patients Who Failed Standard Dose Proton Pump Inhibitors (PPI) NCT00251732 | University of Arizona | Phase 4 |
| Completed | A Study to Evaluate the Effect of Lansoprazole on Infants With Gastroesophageal Reflux Disease. NCT00220818 | Takeda | Phase 1 |
| Completed | Maintenance Intermittent Therapy for Symptomatic GERD Patients NCT00165841 | Eisai Inc. | Phase 2 |
| Completed | NEXIUM® in the Treatment of Moderate and Severe Erosive Esophagitis NCT00206180 | AstraZeneca | Phase 4 |
| Completed | Comparison of the Nighttime Effects of Two Different Drugs on Subjects With GERD NCT00304421 | VA Greater Los Angeles Healthcare System | Phase 4 |
| Completed | Laryngeal and Esophageal EGF-r Expression in Patients With Reflux Laryngitis NCT01806220 | Faculdade de Ciências Médicas da Santa Casa de São Paulo | N/A |
| Completed | True Short Esophagus in Gastroesophageal Reflux Disease NCT03848494 | University of Bologna | — |
| Completed | Evaluation of the Efficiency of Radiofrequency in the Treatment of Gastroesophageal Reflux Disease NCT00200642 | Nantes University Hospital | N/A |
| Completed | Development of a Novel Disease-Specific Quality of Life Questionnaire for Gastroesophageal Reflux Disease (GER NCT00165022 | Chinese University of Hong Kong | — |
| Completed | Symptomatic Gastroesophageal Reflux Disease: Double Blind Randomized Controlled Study of On-demand Therapy Ver NCT00164840 | Chinese University of Hong Kong | Phase 3 |
| Terminated | An Evaluation of the Medtronic Gatekeeper System in the Treatment of SUBJECTS With Gastroesophageal Reflux Dis NCT00200044 | MedtronicNeuro | N/A |
| Completed | Comparison of Laparoscopic Hill and Laparoscopic Nissen Anti-Reflux Procedures NCT01260935 | Swedish Medical Center | N/A |
| Completed | Study Comparing the Effects of Esomeprazole Adminstered Orally and Intravenously on Basal and Pentrigastrin-st NCT00625495 | AstraZeneca | Phase 4 |
| Completed | Evaluate the Effects on Asthma Control of Rabeprazole Given Twice Daily in Subjects With Asthma. NCT00214552 | Associated Scientists to Help Minimize Allergies | Phase 3 |
| Completed | Open, Randomized, Two Way Crossover Study Comparing the Effect of Esomeprazole Adminstered Orally and iv NCT00626262 | AstraZeneca | Phase 4 |
| Completed | Study Comparing Esomeprazole Magnesium 40mg Once Daily Versus Lansoprazole 30 mg Twice Daily in Symptom Contro NCT00637845 | AstraZeneca | Phase 4 |
| Completed | Nissen and Gastroplasty in Gastroesophageal Reflux Disease (GERD) NCT00872755 | G. Hatzikosta General Hospital | Phase 4 |
| Active Not Recruiting | Outcomes After Medical and Surgical Treatment of Gastroesophageal Reflux Disease NCT00260572 | University of Pittsburgh | — |
| Completed | Comparison of Laparoscopic Nissen Versus Thal Fundoplication in Children NCT01027975 | Oxford University Hospitals NHS Trust | N/A |
| Completed | Patient Education in Gastroesophageal Reflux Disease NCT00618150 | Norwegian University of Science and Technology | N/A |
| Withdrawn | Study Comparing Esomeprazole Associated With Sodium Bicarbonate From Eurofarma and Esomeprazole in Treatment o NCT01471925 | Eurofarma Laboratorios S.A. | Phase 3 |
| Completed | Laparoscopic Nissen Versus Toupet Fundoplication: Objective and Subjective Results of a Prospective Randomized NCT01321294 | General Public Hospital Zell am See | N/A |
| Withdrawn | The Potential Therapeutic Effect of Melatonin in Gastro-Esophageal Reflux Disease NCT00915616 | Mansoura University | Phase 3 |
| Unknown | Full-Thickness-Gastroplication For The Treatment Of Gastroesophageal Reflux Disease GERD NCT01453985 | General Public Hospital Zell am See | N/A |
| Completed | A Study to Evaluate the Safety, Tolerability and Pharmacodynamics of Pumosetrag in Patients With Gastroesophag NCT01161602 | Edusa Pharmaceuticals, Inc. | Phase 2 |
| Completed | Economic Impact of Guidelines for Gastroesophageal Reflux Disease NCT00057174 | US Department of Veterans Affairs | N/A |
| No Longer Available | Treatment Use of Domperidone for Gastroparesis NCT02227927 | Scott Gabbard, MD | — |
| Withdrawn | Confocal Endomicroscopy for Non-Erosive Reflux Disease (CE NERD) NCT02039869 | Virginia Commonwealth University | N/A |
| Completed | Laparoscopic Antireflux Surgery Versus Endoscopic Full-thickness Gastroplication for Gastroesophageal Reflux D NCT01324791 | General Public Hospital Zell am See | N/A |