NCT01733810

The Role of HIF-2a in the Pathogenesis of Reflux Esophagitis

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 12 (actual)
• Sponsor: Dallas VA Medical Center · Federal
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to determine the role of hypoxia inducible factor (HIF)-2a on the production of inflammatory cytokines that lead to reflux esophagitis.

Detailed description

Reflux esophagitis is thought to be caused by gastric acid that refluxes into the esophagus, causing injury. Newer data suggest that reflux of gastric juice into the esophagus stimulates HIF-2a, which increases production of inflammatory cytokines. These cytokines are thought to lead to reflux esophagitis. The investigators plan to study the relationship of HIF-2a to inflammatory cytokines in patients with known gastroesophageal reflux disease and reflux esophagitis.

Conditions

• Esophagitis
• Reflux Esophagitis
• Gastroesophageal Reflux Disease

Interventions

Type	Name	Description
OTHER	Cessation of Acid Suppressing Medications	Acid-suppressing medications are stopped for all participants the day after baseline assessment. Subsequent evaluations performed while participant is not on acid-suppressing medications.

Timeline

• Start date: 2013-02-01
• Primary completion: 2015-07-31
• Completion: 2019-07-31
• First posted: 2012-11-27
• Last updated: 2020-02-05

Locations

1 site across 1 country: United States