NCT07108751

Association Between Gastroesophageal Reflux Disease (GERD) Severity and Dental Caries

Association Between Gastroesophageal Reflux Disease (GERD) Severity and Dental Caries: A Cross-Sectional Study

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 200 (actual)
• Sponsor: Tanta University · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

This study aimed to assess the relationship between gastroesophageal reflux disease (GERD) severity (based on upper gastrointestinal endoscopy) and dental caries severity.

Detailed description

Gastroesophageal reflux disease (GERD) is a chronic condition characterized by reflux of stomach acid into the esophagus, with a prevalence reaching 20-30% in many populations. Beyond its gastrointestinal manifestations, GERD may have extraesophageal effects, including oral health disturbances such as dental erosion and caries. Exposure of the oral cavity to gastric acid, especially in patients with severe or nocturnal reflux, may contribute to enamel demineralization, increased tooth decay, and lower salivary pH.

Conditions

• Gastroesophageal Reflux Disease
• Severity
• Dental Caries

Interventions

Type	Name	Description
DEVICE	Endoscopy	Endoscopy will be performed to all patient

Timeline

• Start date: 2025-01-01
• Primary completion: 2025-06-01
• Completion: 2025-06-01
• First posted: 2025-08-07
• Last updated: 2025-08-07

Locations

1 site across 1 country: Egypt