NCT00304421

Comparison of the Nighttime Effects of Two Different Drugs on Subjects With GERD

Comparison of the Nighttime Effects of Rabeprazole 20 mg to Pantoprazole 40 mg on Standard Meal Stimulated Gastric Acid Secretion and Intragastric pH in H. Pylori Negative Volunteer Subjects With GERD

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 23 (estimated)
• Sponsor: VA Greater Los Angeles Healthcare System · Federal
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

The purpose of the study is to compare the effect of two different drugs, rabeprazole (20 mg) and pantoprazole (40 mg), and their effects on the amount of acid produced by your stomach on evening and at night after standard protein meal.

Detailed description

Gastric acid secretion can be divided into two phases: the daytime phase and the nocturnal phase. Nocturnal acid reflux is presumably more damaging because of loss of salivary neutralization. The present study is designed to measure effects of rabeprazole and pantoprazole on post-prandial and nocturnal gastric acid secretion and intragastric pH in H. pylori-negative volunteers with gastroesophageal reflux disease. These measurement will be used to compare the degree of inhibition of gastric acid secretion between the two drugs.

Conditions

• Gastroesophageal Reflux Disease

Interventions

Type	Name	Description
DRUG	rabeprazole
DRUG	pantoprazole

Timeline

• Start date: 2004-01-01
• Completion: 2007-09-01
• First posted: 2006-03-17
• Last updated: 2007-09-17

Locations

1 site across 1 country: United States